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Biomarkers and Personalized Medicine
Sharing relevant articles on advancements in personalized medicine
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DAI provides potential imaging biomarker to indicate brain tumor response to RT - Medical Xpress

DAI provides potential imaging biomarker to indicate brain tumor response to RT - Medical Xpress | Biomarkers and Personalized Medicine | Scoop.it
DAI provides potential imaging biomarker to indicate brain tumor response to RT Medical Xpress Diffusion abnormality index (DAI) shows promise as an imaging biomarker to measure brain tumor response to radiation therapy, according to research being...
Brian Shields's insight:


This is a positive step forward in providing patients with more accurate treatment decisions when Radiation therapy is used to treat brain tumors.


This Biomarker is a new diffusion index, DAI, which could potentially indicate post-treatment tumor response.

"While this review included a small number of patients, the data demonstrate that DAI may be a good biomarker to predict brain tumor response," said lead study author Reza Farjam, a PhD candidate in biomedical engineering focused on cancer functional imaging at the University of Michigan in Ann Arbor, Mich. "Further study of this method is needed to improve early prediction of tumor response to radiation therapy and to help us provide brain cancer patients with more accurate information about their treatment progress."

Read more at: http://medicalxpress.com/news/2013-02-dai-potential-imaging-biomarker-brain.html#jCp


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Glioblastoma patients with modified PTEN have resistance to EGFR inhibitors

Despite years of research, glioblastoma, the most common and deadly brain cancer in adults, continues to outsmart treatments targeted to inhibit tumor growth.
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PCGP Study Finds Potential Drug Targets in Medulloblastoma Subgroups ... - GenomeWeb

PCGP Study Finds Potential Drug Targets in Medulloblastoma Subgroups ... - GenomeWeb | Biomarkers and Personalized Medicine | Scoop.it

PCGP Study Finds Potential Drug Targets in Medulloblastoma Subgroups ...Giles Robinson, the study's lead author, told Clinical Sequencing News that the main achievement of the study was identifying mutations that correlate with disease...

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An LXR Agonist Promotes Glioblastoma Cell Death through Inhibition of an EGFR/AKT/SREBP-1/LDLR–Dependent Pathway

An LXR Agonist Promotes #Glioblastoma Cell Death through Inhibition of an EGFR/AKT/SREBP-1/LDLR–Dependent Pathway - http://t.co/d02zoCjN...
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Missing Gene: A Cause for Common Brain Cancer? « Profncampbell's Blog

Missing Gene: A Cause for Common Brain Cancer? « Profncampbell's Blog | Biomarkers and Personalized Medicine | Scoop.it
It's been known for 25 years that EGFR plays a role in glioblastoma as well as many other cancers and that this gene is aberrantly activated in glioblastoma,” lead investigator and visiting associate professor at ...
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Biomarker May Stratify TBI Patients

The biomarker glial fibrillary acidic protein accurately distinguished between mild and moderate traumatic brain injury, between mild traumatic injury patien...
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Glioblastoma-derived Leptin Induces Tube Formation and Growth of Endothelial Cells: Comparison with VEGF Effects - Life Sciences Social Network

Glioblastoma-derived Leptin Induces Tube Formation and Growth of Endothelial Cells: Comparison with VEGF Effects - Life Sciences Social Network | Biomarkers and Personalized Medicine | Scoop.it
Glioblastoma-derived Leptin Induces Tube Formation and Growth of Endothelial Cells: Comparison with VEGF Effects (Glioblastoma-derived Leptin Induces Tube Formation and Growth of Endothelial Cells: Comparison with VEGF Effects http://dlvr.it/bnlSG...)...
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Genetic landscape of common brain tumors holds key to personalized treatment - EurekAlert (press release)

Exciting information on the recognition of the NF2 gene as a target for treatment of meningiomas
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Better treatment for brain cancer revealed by new molecular insights

Excerpt from article: "Nearly a third of adults with the most common type of brain cancer develop recurrent, invasive tumors after being treated with a drug called bevacizumab.The molecular underpinnings behind these detrimental effects have now been published by Cell Press in the July issue of Cancer Cell. The findings reveal a new treatment strategy that could reduce tumor invasiveness and improve survival in these drug-resistant patients. "Understanding how and why these tumors adopt this invasive behavior is critical to being able to prevent this recurrence pattern and maximizing the benefits of bevacizumab," says study author Kan Lu of the University of California, San Francisco (UCSF)."

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Oncogene - Acquired MET expression confers resistance to EGFR inhibition in a mouse model of glioblastoma multiforme

Oncogene - Acquired MET expression confers resistance to EGFR inhibition in a mouse model of glioblastoma multiforme | Biomarkers and Personalized Medicine | Scoop.it

Exceprt from abstract:

"Inhibition of EGFR kinase activity using tyrosine kinase inhibitors in GBM tumor cells generates a cytostatic response characterized by a cell cycle arrest, which is accompanied by a substantial change in global gene expression levels. We demonstrate that an important component of this pattern is the transcriptional activation of the MET receptor tyrosine kinase and that pharmacological inhibition of MET overcomes the resistance to EGFR inhibition in these cells. These findings provide important new insights into mechanisms of resistance to EGFR inhibition and suggest that inhibition of multiple targets will be necessary to provide therapeutic benefit for GBM patients."

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To Treat Brain Tumors, New Compound Delivers Both Diagnostic and Therapeutic Agents

To Treat Brain Tumors, New Compound Delivers Both Diagnostic and Therapeutic Agents | Biomarkers and Personalized Medicine | Scoop.it
Researchers from Virginia Commonwealth University and Virginia Tech have developed a molecule that could be used to help diagnose as well as treat brain tu (To Treat Brain Tumors, New Compound Delivers Both Diagnostic and Therapeutic Agents
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NIH-Funded Researchers Assess Traumatic Brain Injury Biomarkers ...

Biomarkers in the bloodstream could provide physicians with a quick and accurate method of assessing the severity of traumatic brain injury (TBI) and helping deliver and monitor the results of therapies, ...
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