Crosstalk among FLT-3,PTEN,PI3K signaling pathway,Notch, and p53 | Pi3K AKT Blog | Biomarkers and Personalized Medicine |

"This is another part of my article and I share with you now.
As PTEN is a suppressor of PI3K-akt signaling pathway, it is easy to find PTEN mutation in tumor cells.In T-ALL, Notch signaling pathway can regulate PTEN (phosphatase and tensin homolog) through HES1 and cMYC. Both HES1 and cMYC are transcriptional activators which are directly controlled by Notch1. They can control the expression of PTEN by binding to the PTEN promoter directly..."