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Rescooped by Zineb Sekkat from Stem Cells & Tissue Engineering
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Scientists Are 3D Printing Whole Cancer Tumors From Scratch

Scientists Are 3D Printing Whole Cancer Tumors From Scratch | Biology | Scoop.it

Via Jacob Blumenthal
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Jacob Blumenthal's curator insight, April 27, 2014 12:48 AM

Scientists from Philadelphia have bioprinted a mixture of cancerous cell line called HeLa cells, and hydrogel to form 3D tumors. The HeLa cells line was generated from tumor cells taken from  Henrietta Lacks, in the 1950s and are considered as the first "immortal" line of research cells. 

Read the paper: http://iopscience.iop.org/1758-5090/6/3/035001/article

 

MAIC's curator insight, December 15, 2015 4:40 AM

Scientists from Philadelphia have bioprinted a mixture of cancerous cell line called HeLa cells, and hydrogel to form 3D tumors. The HeLa cells line was generated from tumor cells taken from  Henrietta Lacks, in the 1950s and are considered as the first "immortal" line of research cells. 

Read the paper: http://iopscience.iop.org/1758-5090/6/3/035001/article

 

Rescooped by Zineb Sekkat from Plant Immunity And Microbial Effectors
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Plant PRRs and the Activation of Innate Immune Signaling: Molecular Cell

Plant PRRs and the Activation of Innate Immune Signaling: Molecular Cell | Biology | Scoop.it

Despite being sessile organisms constantly exposed to potential pathogens and pests, plants are surprisingly resilient to infections. Plants can detect invaders via the recognition of pathogen-associated molecular patterns (PAMPs) by pattern recognition receptors (PRRs). Plant PRRs are surface-localized receptor-like kinases, which comprise a ligand-binding ectodomain and an intracellular kinase domain, or receptor-like proteins, which do not exhibit any known intracellular signaling domain. In this review, we summarize recent discoveries that shed light on the molecular mechanisms underlying ligand perception and subsequent activation of plant PRRs. Notably, plant PRRs appear as central components of multiprotein complexes at the plasma membrane that contain additional transmembrane and cytosolic kinases required for the initiation and specificity of immune signaling. PRR complexes are under tight control by protein phosphatases, E3 ligases, and other regulatory proteins, illustrating the exquisite and complex regulation of these molecular machines whose proper activation underlines a crucial layer of plant immunity.


Via IPM Lab
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