Molecular Imaging Probes for Cancer Research book download Xiaoyuan Chen Download Molecular Imaging Probes for Cancer Research Global QuickSearch: Number of matching entries: 0.. Learn more about the history of ...
We’ve all heard the miracle stories about people who cured themselves of cancer by following a macrobiotic diet. But is it really possible? Can our food actually control our cells and affect our genetic information? A recent study has shown that consumption of miRNAsfrom plants we eat may result in the regulation of related target genes in our bodies, opening the door for research concerning the extent of the effects our diets truly have on our bodies.
By fine-tuning the design of fluorescent probes and RNA fixation techniques, researchers have developed a way to detect and quantify microRNA molecules in tumor biopsy samples. The new fluorescence in situ hybridization (FISH) method allows the identification of tumor types that contain unique combinations of microRNAs. And unlike previous methods, the approach allows the simultaneous detection of multiple microRNAs while leaving the biopsy sample intact.
Scientist Piece by Piece Scientist For a long while this shut academic labs out of such searches, but a related technique, fragment-based drug discovery (also called fragment-based lead discovery), offers another way to develop small-molecule drugs...
Trans-acting small interfering RNAs (tasiRNAs) are a major class of small RNAs performing essential biological functions in plants. The first reported tasiRNA pathway, that of miR173-TAS1/2, produces tasiRNAs regulating a set of pentatricopeptide repeat (PPR) genes and has been characterized only in Arabidopsis thaliana to date. Here, we demonstrate that the microRNA (miRNA)-transacting small interfering RNA gene (TAS)-pentatricopeptide repeat-containing gene (PPR)-small interfering RNA pathway is a highly dynamic and widespread feature of eudicots. Nine eudicot plants, representing six different plant families, have evolved similar tasiRNA pathways to initiate phased small interfering RNA (phasiRNA) production from PPR genes. The PPR phasiRNA production is triggered by different 22-nucleotide miRNAs, including miR7122, miR1509, and fve-PPRtri1/2, and through distinct mechanistic strategies exploiting miRNA direct targeting or indirect targeting through TAS-like genes (TASL), one-hit or two-hit, or even two layers of tasiRNA–TASL interactions. Intriguingly, although those miRNA triggers display high sequence divergence caused by the occurrence of frequent point mutations and splicing shifts, their corresponding MIRNA genes show pronounced identity to the Arabidopsis MIR173, implying a common origin of this group of miRNAs (super-miR7122). Further analyses reveal that super-miR7122 may have evolved from a newly defined miR4376 superfamily, which probably originated from the widely conserved miR390. The elucidation of this evolutionary path expands our understanding of the course of miRNA evolution, especially for relatively conserved miRNA families.
miRNA: The Key to Losing Those Love Handles? Genetic Engineering News The researchers have now decoded a microRNA switch in mice that is important for brown fat cells. The researchers specifically studied microRNA 155.
Felix J. Tapia's insight:
A miracle: Regulatory miRNA may convert white fat cells into brown fat cells, giving the key to control obesity
In-Situ Hybridization Techniques on Paraffin-Embedded Tissue. Presented on March 21, 2013. Presented by Laura Vivian, HT(ASCP)QIHC, Capital Digestive Care, Laboratory Division. Posted in IHC. Enormous advancements in molecular ...
Researchers develop multicolor fluorescence labeling method to identify tumor ... News-Medical.net In recent years, microRNAs (miRNAs) and other non-coding RNAs are small molecules that help control the expression of specific proteins.
This Week in PNAS RNAi News (blog) Our experts also discuss the use of SmartFlare RNA detection probes for the direct quantification of circulating miRNAs with rapid processing of blood plasma/serum, which is done without the use of enzymes.
An atomic force microscope probes a molecule adsorbed onto a surface, using a carbon monoxide molecule at the tip for sensitivity. Fischer is developing new techniques for making graphene nanostructures that display ...
Nature World News New Technique Capable of Imaging Molecules Before and After Reactions ... Nature World News An atomic force microscope probes a molecule adsorbed onto a surface, using a carbon monoxide molecule at the tip for sensitivity.
The polymerase chain reaction (PCR) plays a leading role in today’s biology. PCR started with an endpoint approach that detected a particular nucleic-acid sequence. Then, real-time PCR provided relative quantification of the sequences.
Oncology Medical Article: Intratumour variation of biomarker expression by immunohistochemistry in resectable non-small cell lung cancer (Intratumour variation of biomarker expression by immunohistochemistry in resectable non-small ...
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