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Moshe Oren on taking transcriptomics to the next level with 4sUDRB-seq

Research in Genome Biology presents a novel method to measure transcription elongation rates genome-wide, 4sUDRB-seq | Research published by BioMed Central
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Tools and tips for scientific tinkers and tailors
Next gen sequencing, bioinformatics, virology, microbiology, genomes, zoonoses, workshops, conferences, all-around science geekery
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PLOS Computational Biology: Confronting the Ethical Challenges of Big Data in Public Health

PLOS Computational Biology: Confronting the Ethical Challenges of Big Data in Public Health. Editorial by @pebourne. http://t.co/dxXkZaYXaV
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Ebola virus disease: obliterating a variant and stalled case decline...

Ebola virus disease: obliterating a variant and stalled case decline... | Tools and tips for scientific tinkers and tailors | Scoop.it
We've seen the words vigilant and vigilance used widely in recent weeks, ever since we entered a "new phase" of the Ebola virus disease (EVD) battle/fight/war.
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The more things change, the more they change

I just had the pleasure of spending a couple days hiking around the interior of Catalina Island. The last time I did this was about 23 years ago, when I was a student on an undergraduate field trip...
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Insight from Chris Buddle: "I am my own postdoc" - couldn't agree more. Read the inspiration at small pond science.

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Targeted diversity generation by intraterrestrial archaea and archaeal viruses : Nature Communications : Nature Publishing Group

Targeted diversity generation by intraterrestrial archaea and archaeal viruses : Nature Communications : Nature Publishing Group | Tools and tips for scientific tinkers and tailors | Scoop.it
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New species of leprosy bacteria found

New species of leprosy bacteria found | Tools and tips for scientific tinkers and tailors | Scoop.it


Scientists have compared for the first time the genomes of the two bacteria species that cause leprosy. The study shows how the two species evolved from a common ancestor around 13.9 million years ago, and offers new insights into their biology that could lead to new treatments.




Via Dr. Stefan Gruenwald
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TWiV 329: Pox in the balance

TWiV 329: Pox in the balance | Tools and tips for scientific tinkers and tailors | Scoop.it
Identification of immune biomarkers in CFS/ME patients, and how a cell nuclease controls the innate immune response to vaccinia virus infection.
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Useful Ebola virus disease graphics...

Useful Ebola virus disease graphics... | Tools and tips for scientific tinkers and tailors | Scoop.it
Good graphics can be really helpful to convey information quickly - and no-one has time to read words anymore right?
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The Genealogical World of Phylogenetic Networks: Phylogenetic network of pairwise alignment methods

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Pandemic disease - The Economist

The Economist offers authoritative insight and opinion on international news, politics, business, finance, science, technology and the connections between them.
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‘Coding’ in Genetics is not the Same as ‘Coding’ in Computing

While going through various discussions on non-coding DNA, I realized that some of the confusion is possibly caused by dual use of the word ‘coding’.
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Bacterial Infection Drives the Expression Dynamics of microRNAs and Their isomiRs

Bacterial Infection Drives the Expression Dynamics of microRNAs and Their isomiRs | Tools and tips for scientific tinkers and tailors | Scoop.it
by Katherine J. Siddle, Ludovic Tailleux, Matthieu Deschamps, Yong-Hwee Eddie Loh, Cécile Deluen, Brigitte Gicquel, Christophe Antoniewski, Luis B.
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Superbug risk from tonnes of antibiotics fed to animals - health - 23 March 2015 - New Scientist

A side of superbugs with your steak? Farm animals are fed 63,000 tonnes of antibiotics a year, exacerbating the problem of antibiotic resistance
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Rescooped by Mel Melendrez-Vallard from Virology and Bioinformatics from Virology.ca
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The Causes and Consequences of Changes in Virulence following Pathogen Host Shifts

The Causes and Consequences of Changes in Virulence following Pathogen Host Shifts | Tools and tips for scientific tinkers and tailors | Scoop.it
Author Summary Many emerging infectious diseases are the result of a host shift, with the pathogen jumping into the new host from another species.

Via burkesquires
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Viral RNA Intermediates as Targets for Detection and Discovery of Novel and Emerging Mosquito-Borne Viruses

by Caitlin A. O’Brien, Jody Hobson-Peters, Alice Wei Yee Yam, Agathe M. G. Colmant, Breeanna J. McLean, Natalie A. Prow, Daniel Watterson, Sonja Hall-Mendelin, David Warrilow, Mah-Lee Ng, Alexander A.
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Insight into the evolution and origin of leprosy bacilli from the genome sequence of Mycobacterium lepromatosis

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The Genome Analysis Centre - Take on MinIon

The Genome Analysis Centre - Take on MinIon | Tools and tips for scientific tinkers and tailors | Scoop.it
A world leading research Institute focussed on advancing bioscience by enabling and developing computational and genomics data-driven approaches in biology. National Capability funded by the BBSRC.
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Scientists Use DNA Sequencing to Trace the Spread of Drug-Resistant TB

Scientists have for the first time used DNA sequencing to trace the fatal spread of multidrug-resistant tuberculosis between patients in the UK.
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It's time to reboot bioinformatics education

It's time to reboot bioinformatics education | Tools and tips for scientific tinkers and tailors | Scoop.it
Nearly 15 years after completion of the human genome, undergraduate and graduate programs still aren't adequately training future scientists with the basic bioinformatics skills needed to be succes...
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Clontech Gains Access to Smart-seq2 Single-Cell RNA-Seq Technology | RNA-Seq Blog

MOUNTAIN VIEW, Calif., March 23, 2015 /PRNewswire/ -- Clontech Laboratories, Inc., a wholly-owned subsidiary of Takara Bio Inc., today announced that it has
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Detailed Contact Data and the Dissemination of Staphylococcus aureus in Hospitals

Detailed Contact Data and the Dissemination of  Staphylococcus aureus  in Hospitals | Tools and tips for scientific tinkers and tailors | Scoop.it
Author Summary Recent advances in communication technologies allow monitoring high-resolution contact networks. Close proximity interactions (CPIs) measured by wireless sensors are increasingly used to inform contact networks for the dissemination of pathogens in computational models, although empirical justification is lacking. Here, we conducted a longitudinal prospective study for four months in a hospital, including both patients and healthcare workers (HCWs). High-resolution CPIs were re
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Liberia enters the next phase of Ebola virus disease (EVD) eradication with a new case...

Liberia enters the next phase of Ebola virus disease (EVD) eradication with a new case... | Tools and tips for scientific tinkers and tailors | Scoop.it
version 2 What a heartbreaking disappointment this is for the people of Liberia, with a reported new case of EVD in a woman who tested positive for Ebola virus on Friday in Monrovia, Liberia.[2] after more then 3-weeks with zero new cases and no...
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PacBio-LITS: a large-insert targeted sequencing method for characterization of human disease-associated chromosomal structural variations

Background:
Generation of long (>5 Kb) DNA sequencing reads provides an approach for interrogation of complex regions in the human genome.
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Discovery of Novel Rhabdoviruses in the Blood of Healthy Individuals from West Africa

Discovery of Novel Rhabdoviruses in the Blood of Healthy Individuals from West Africa | Tools and tips for scientific tinkers and tailors | Scoop.it
by Matthew H. Stremlau, Kristian G. Andersen, Onikepe A. Folarin, Jessica N. Grove, Ikponmwonsa Odia, Philomena E. Ehiane, Omowunmi Omoniwa, Omigie Omoregie, Pan-Pan Jiang, Nathan L. Yozwiak, Christian B.
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Within-Host Bacterial Diversity Hinders Accurate Reconstruction of Transmission Networks from Genomic Distance Data

Author Summary With the advent of affordable large-scale genome sequencing for bacterial pathogens, there is much interest in using such data to identify who infected whom in a disease outbreak.
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Detection of new genetic variants of Betacoronaviruses in Endemic Frugivorous Bats of Madagascar

Background:
Bats are amongst the natural reservoirs of many coronaviruses (CoVs) of which some can lead to severe infection in human.
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Integrating Interactive Computational Modeling in Biology Curricula

While the use of computer tools to simulate complex processes such as computer circuits is normal practice in fields like engineering, the majority of life sciences/biological sciences courses continue to rely on the traditional textbook and...
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