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Rescooped by Mel Melendrez-Vallard from Bioinformatics, Comparative Genomics and Molecular Evolution
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How Computers Are Changing Biology

How Computers Are Changing Biology | Tools and tips for scientific tinkers and tailors | Scoop.it
Sophisticated computer models and simulations are replacing test tubes and beakers. This revolution in biology research is redefining medicine, agriculture, and more.

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Arjen ten Have's curator insight, May 12, 4:08 PM

A rather positive view: as an independent source of evidence. I dig it but people that do not work on biocomputation just do not.

Tools and tips for scientific tinkers and tailors
Next gen sequencing, bioinformatics, virology, microbiology, genomes, zoonoses, workshops, conferences, all-around science geekery
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Scooped by Mel Melendrez-Vallard
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Mapping Human Disease: ‘Not All Pathogens Are Everywhere’

Mapping Human Disease: ‘Not All Pathogens Are Everywhere’ | Tools and tips for scientific tinkers and tailors | Scoop.it
NC State researchers map human disease pathogens, find
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Integrating transcriptome and genome sequencing | RNA-Seq Blog

Integrating transcriptome and genome sequencing | RNA-Seq Blog | Tools and tips for scientific tinkers and tailors | Scoop.it
A practical webinar highlighting genetic data integration approaches featuring Dr. Tuuli Lappalainen. Explore the power of genome and transcriptome data
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The trade-off between increased multiplexing and decreasing sequencing depth in smallRNA-Seq

The trade-off between increased multiplexing and decreasing sequencing depth in smallRNA-Seq | Tools and tips for scientific tinkers and tailors | Scoop.it
Small RNA sequencing can be used to gain an unprecedented amount of detail into the microRNA transcriptome. The relatively high cost and low throughput of sequencing bases technologies can potentially be offset by the use of multiplexing.
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Vaccine against prion disease, not for humans... yet

Prions, misfolded proteins that wreak havoc on the brain, may have finally met their match. Best known for things like mad cow disease and possibly alzheimer's disease scientists have had no luck s...
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A History of Bioinformatics (in the Year 2039)

C. Titus Brown http://video.open-bio.org/video/1/a-history-of-bioinformatics-in-the-year-2039.
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Ebola double vision is clearing...

Ebola double vision is clearing... | Tools and tips for scientific tinkers and tailors | Scoop.it
A quick follow up from my post in October entitled "Ebola double vision".
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Molecular Epidemiology of Carbapenem Non-Susceptible Acinetobacter baumannii in France

Molecular Epidemiology of Carbapenem Non-Susceptible Acinetobacter baumannii in France | Tools and tips for scientific tinkers and tailors | Scoop.it
by Katy Jeannot, Laure Diancourt, Sophie Vaux, Michelle Thouverez, Amandina Ribeiro, Bruno Coignard, Patrice Courvalin, Sylvain Brisse
Carbapenem-resistant Acinetobacter baumannii have emerged globally.
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Rescooped by Mel Melendrez-Vallard from Virology and Bioinformatics from Virology.ca
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Virology Journal | Abstract | The diversity of human papillomavirus infection among human immunodeficiency virus-infected women in Yunnan, China

Yunnan has one of the oldest and the most severe human immunodeficiency virus (HIV) epidemics in China.

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Genome Biology | Full text | Low frequency of paleoviral infiltration across the avian phylogeny

Mammalian genomes commonly harbor endogenous viral elements. Due to a lack of comparable genome-scale sequence data, far less is known about endogenous viral elements in avian species, even though their small genomes may enable important insights into the patterns and processes of endogenous viral element evolution.
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Distinct Genealogies for Plasmids and Chromosome

Distinct Genealogies for Plasmids and Chromosome | Tools and tips for scientific tinkers and tailors | Scoop.it
by Mark Achtman, Zhemin Zhou
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Rescooped by Mel Melendrez-Vallard from DNA & RNA Research
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New Understanding of Macrophage Gene Regulation Could Help Control Cancer, Other Diseases

New Understanding of Macrophage Gene Regulation Could Help Control Cancer, Other Diseases | Tools and tips for scientific tinkers and tailors | Scoop.it

Weill Cornell Medical College researchers have created a database that maps how a cell important for blood vessel growth regulates gene expression. The new knowledge of the cells, called macrophages, could provide strategies to stop tumor or cancer growth.


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Herpes Virus Rearranges Telomeres to Improve Viral Replication

A team of scientists, led by researchers at The Wistar Institute, has found that an infection with herpes simplex virus 1 (HSV-1) causes rearrangements in telomeres, small stretches of DNA that serve as protective ends to chromosomes. The findings, which will be published in the Dec. 24 edition of the journal Cell Reports, show that this manipulation of telomeres may explain how viruses like herpes are able to successfully replicate while also revealing more about the protective role that telomeres play against other viruses.


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Plague in Surat: 20 Years Later

Plague in Surat: 20 Years Later | Tools and tips for scientific tinkers and tailors | Scoop.it
I can't let 2014 pass in a few weeks without mentioning that this fall was the twentieth anniversary of the plague outbreak in Surat, India -- a major turning point in modern plague history and in ...
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Mysterious Virus That Killed a Farmer in Kansas Is Identified

The newly identified infectious agent most closely resembles viruses that are spread by ticks and mosquitoes and are found on other continents.
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Avian Flu Diary: Kansas DOH Statement On New, Possibly Tickborne Virus

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Assessment of microRNA differential expression and detection in multiplexed small RNA sequencing data

A monthly journal publishing high-quality, peer-reviewed research on all topics related to RNA and its metabolism in all organisms
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It’s a big, big world for non-coding RNAs

My past two blogs explored the broad topics of gene expression and epigenetics. Oh boy, our cells’ genetic complexity skyrockets after considering the role epigenetics has in biology.
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Nathan Wolfe: On the Hunt for New Viruses - Wall Street Journal

Virologist Nathan Wolfe on the race to find new diseases and the growing risk of epidemics.
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Genome-Wide SNP-Genotyping Array to Study the Evolution of the Human Pathogen Vibrio vulnificus Biotype 3

Genome-Wide SNP-Genotyping Array to Study the Evolution of the Human Pathogen Vibrio vulnificus Biotype 3 | Tools and tips for scientific tinkers and tailors | Scoop.it
by Nili Raz, Yael Danin-Poleg, Ryan B. Hayman, Yudi Bar-On, Alex Linetsky, Michael Shmoish, Eva Sanjuán, Carmen Amaro, David R. Walt, Yechezkel Kashi
Vibrio vulnificus is an aquatic bacterium and an important human pathogen.
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The host metabolite D-serine contributes to bacterial niche specificity ... - Nature.com

The host metabolite D-serine contributes to bacterial niche specificity ... - Nature.com | Tools and tips for scientific tinkers and tailors | Scoop.it
The ISME Journal: Multidisciplinary Journal of Microbial Ecology is the official Journal of the International Society for Microbial Ecology, publishing high-quality, original research papers, short communications, commentary articles and reviews in...
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Metagenomic Analysis of Viruses in Feces from Unsolved Outbreaks of Gastroenteritis in Humans

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Rescooped by Mel Melendrez-Vallard from DNA & RNA Research
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Method predicts impact of DNA variants on gene expression

Method predicts impact of DNA variants on gene expression | Tools and tips for scientific tinkers and tailors | Scoop.it

A new computational approach predicts how sequence variations in both the coding and noncoding regions of a gene affect the gene’s expression. The method, described today inScience, may help researchers understand how specific variants contribute to disorders such as autism.


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Rescooped by Mel Melendrez-Vallard from Virology and Bioinformatics from Virology.ca
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MAVS, cGAS, and endogenous retroviruses in T-independent B cell responses

Scattered across our genome are endogenous retroviruses (ERVs), ancient “footprints” of previous viral infections. Scientists do not fully understand their functions, but Zeng et al. now report a role for ERVs in mobilizing a particular type of B cell–driven immune response in mice (T cell–independent, TID), which is usually mounted in response to viral capids or bacterial polysaccharides (see the Perspective by Grasset and Cerutti). Immunizing mice with a model TID antigen elicited an increase in ERV RNA and DNA in the cytoplasm of B cells. Innate immune receptors that recognize cytoplasmic nucleotides then triggered signaling cascades that resulted in the production of immunoglobulin M.

 


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Virology Journal | Full text | Plant-based vaccines against viruses

Plant-made or “biofarmed” viral vaccines are some of the earliest products of the technology of plant molecular farming, and remain some of the brightest prospects for the success of this field. Proofs of principle and of efficacy exist for many candidate viral veterinary vaccines; the use of plant-made viral antigens and of monoclonal antibodies for therapy of animal and even human viral disease is also well established. This review explores some of the more prominent recent advances in the biofarming of viral vaccines and therapies, including the recent use of ZMapp for Ebolavirus infection, and explores some possible future applications of the technology.
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The Global Burden of Disease: non-communicable diseases increase premature death

Up-to-date knowledge of cause-specific mortality is essential for the formulation of health policies. Obtaining this evidence is a massive undertaking, and probably the largest attempt to do so is the landmark Global Burden of Disease Study 2010 (GBD 2010). This was the largest ever systematic effort to describe the global distribution and causes of major diseases, injuries, and health risk factors.
In the first in a series of papers has been published in the Lancet today, GBD 2010 has been upda
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