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Rescooped by stoian ioan from Genomic Parasites: Coevolution between host and parasites
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Casposons: a new superfamily of self-synthesizing DNA transposons at the origin of prokaryotic CRISPR-Cas immunity

Diverse transposable elements are abundant in genomes of cellular organisms from all three domains of life. Although transposons are often regarded as junk DNA, a growing body of evidence indicates that they are behind some of the major evolutionary innovations. With the growth in the number of diversity of sequenced genomes, previously unnoticed mobile elements continue to be discovered.

We describe a new superfamily of archaeal and bacterial mobile elements which we denote casposons because they encode Cas1 endonuclease, a key enzyme of the CRISPR-Cas adaptive immunity systems of archaea and bacteria. The casposons share several features with self-synthesizing eukaryotic DNA transposons of the Polinton/Maverick class, including terminal inverted repeats and genes for B family DNA polymerases. However, unlike any other known mobile elements, the casposons are predicted to rely on Cas1 for integration and excision, via a mechanism similar to the integration of new spacers into CRISPR loci. We identify three distinct families of casposons that differ in their gene repertoires and evolutionary provenance of the DNA polymerases. Deep branching of the casposon-encoded endonuclease in the Cas1 phylogeny suggests that casposons played a pivotal role in the emergence of CRISPR-Cas immunity.

The casposons are a novel superfamily of mobile elements, the first family of putative self-synthesizing transposons discovered in prokaryotes. The likely contribution of capsosons to the evolution of CRISPR-Cas parallels the involvement of the RAG1 transposase in vertebrate immunoglobulin gene rearrangement, suggesting that recruitment of endonucleases from mobile elements as ready-made tools for genome manipulation is a general route of evolution of adaptive immunity.

 

 


Via THE_inteins, Gabriel Wallau
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Rescooped by stoian ioan from Leadership, Innovation, and Creativity
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Lessons on Leadership from Children's Books - Huffington Post

Lessons on Leadership from Children's Books - Huffington Post | bibliofilie | Scoop.it
Lessons on Leadership from Children's Books
Huffington Post
Being a leader is a complex task, but the defining moments of great leadership can be surprisingly simple.

Via John Michel, Ivon Prefontaine
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John Michel's curator insight, May 19, 2014 9:02 AM

"If I were building a leadership library, I would stock it with these nine children's books. Each captures a key decision of a favorite leader, and matches up with research evidence:"

Ivon Prefontaine's curator insight, May 19, 2014 12:37 PM

A list with Dr. Seuss is a good list.

Rescooped by stoian ioan from Plant immunity and legume symbiosis
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Frontiers | The role of the cell wall in plant immunity | Plant-Microbe Interaction

Frontiers | The role of the cell wall in plant immunity | Plant-Microbe Interaction | bibliofilie | Scoop.it
The battle between plants and microbes is evolutionarily ancient, highly complex and often co-dependent. A primary challenge for microbes is to breach the physical barrier of host cell walls whilst avoiding detection by the plant’s immune receptors. While some receptors sense conserved microbial features, others monitor physical changes caused by an infection attempt. Detection of microbes leads to activation of appropriate defense responses that then challenge the attack. Plant cell walls are formidable and dynamic barriers. They are constructed primarily of complex carbohydrates joined by numerous distinct connection types, and are subject to extensive post-synthetic modification to suit prevailing local requirements. Multiple changes can be triggered in cell walls in response to microbial attack. Some of these are well described, but many remain obscure. The study of the myriad of subtle processes underlying cell wall modification poses special challenges for plant glycobiology. In this review we describe the major molecular and cellular mechanisms that underlie the roles of cell walls in plant defense against pathogen attack. In so doing, we also highlight some of the challenges inherent in studying these interactions, and briefly describe the analytical potential of molecular probes used in conjunction with carbohydrate microarray technology.

Via Christophe Jacquet
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Rescooped by stoian ioan from The Historian's Point of View
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Hanging Gardens Existed, but not in Babylon

Hanging Gardens Existed, but not in Babylon | bibliofilie | Scoop.it
An Oxford researcher says she has found evidence of the elusive Hanging Gardens of Babylon—but 300 miles from Babylon.

Via Carolyn Schriber
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Rescooped by stoian ioan from The Historian's Point of View
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The Mary Rose crew members revealed

The Mary Rose crew members revealed | bibliofilie | Scoop.it
The secrets of Henry VIII's flagship, the Mary Rose, are being revealed to the public - along with the faces of its crew.

Via Carolyn Schriber
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Rescooped by stoian ioan from The Historian's Point of View
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New theory: Alexander the Great poisoned by flowering herb? - NBC News.com

New theory: Alexander the Great poisoned by flowering herb? - NBC News.com | bibliofilie | Scoop.it
On June 11, 323 B.C., the famed Alexander the Great died, felled by a mysterious illness that left him too weak to move. Ever since,...

Via Carolyn Schriber
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Rescooped by stoian ioan from economics
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Destruction of a Prosperous Nation State: The Fall of Yugoslavia and the US-NATO Led War

Destruction of a Prosperous Nation State: The Fall of Yugoslavia and the US-NATO Led War | bibliofilie | Scoop.it
For years, the dismantling of Yugoslavia was no more than a half-completed job in the eyes of Western leaders. The United States and Western European nations lavished financial, diplomatic, politic...

Via Gavin Dhir
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Rescooped by stoian ioan from Picture Perfect
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Designing The Image You Want (a Chapter from My Book, Lighting ...

Designing The Image You Want (a Chapter from My Book, Lighting ... | bibliofilie | Scoop.it
Designing The Image You Want (a Chapter from My Book, Lighting Essentials). Today I present an excerpt from my book, “Lighting Essentials: A Subject-Centric Approach for Photographers” now available from Amazon and ...

Via Patricia Coffey
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Rescooped by stoian ioan from Figura Publica
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iMNK - Wirtualne Muzeum Narodowe w Krakowie

Wirtualne Muzeum Narodowe w Krakowie prezentuje wybrane galerie stałe oraz wystawy czasowe.

Via Figura Publica
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Rescooped by stoian ioan from bibliofilie
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iMNK - Wirtualne Muzeum Narodowe w Krakowie

Wirtualne Muzeum Narodowe w Krakowie prezentuje wybrane galerie stałe oraz wystawy czasowe.

Via Figura Publica, stoian ioan
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Rescooped by stoian ioan from Children's book view
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Some the Wiser: Ten Great Children's Non-Fiction Books

Some the Wiser: Ten Great Children's Non-Fiction Books | bibliofilie | Scoop.it
Ten Great Children's Non-Fiction Books http://t.co/XutYLKyOn0

Via bobbygw, kevinye
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kevinye's curator insight, September 11, 2013 10:36 PM

Great children book printing in CM Color Printing Company is providing,you can connect us and booking your own book to print.Glad to contact us`````

Rescooped by stoian ioan from The Historian's Point of View
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Göbekli Tepe - Pictures, More From National Geographic Magazine

Göbekli Tepe - Pictures, More From National Geographic Magazine | bibliofilie | Scoop.it
The Birth of Religion: We used to think agriculture gave rise to cities and later to writing, art, and religion. Now the world’s oldest temple suggests the urge to worship sparked civilization.

Via Carolyn Schriber
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Rescooped by stoian ioan from The Historian's Point of View
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bibliotheca Augustana


Via Carolyn Schriber
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Carolyn Schriber's curator insight, October 14, 2013 10:18 AM

Medievalists and other fans of the Norman invasion of England: View wthe entire Bayeux Tapestry here. 

Rescooped by stoian ioan from The Historian's Point of View
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Viking apocalypse: End of the world predicted to happen on Saturday (but don't cancel your weekend plans yet)

Viking apocalypse: End of the world predicted to happen on Saturday (but don't cancel your weekend plans yet) | bibliofilie | Scoop.it
The end of the world is almost upon us if Norse mythology is to be believed, which predicts the Earth will split open and release the inhabitants of the underworld on 22 February.

Via Carolyn Schriber
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Rescooped by stoian ioan from International Politics in Korea
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North Korea ‘planning third nuclear test’ - FT.com

North Korea ‘planning third nuclear test’ - FT.com | bibliofilie | Scoop.it
SEOUL, April 8 – North Korea, pressing ahead with a rocket launch in defiance of a UN resolution, is also preparing a third nuclear weapons test, South Korean news reports said on Sunday, a move bound to scare neighbours and infuriate the west.

 

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North Korea planning third nuclear test ...

Situation of north-east Asia is totally frozen...

If North Korea forcing their nuclear test bring the 'World War 3' 

What do you think about it !?


Via Song Ik-june(Gerrard)
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Rescooped by stoian ioan from carti online
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7 decembrie 1941 - ziua care a schimbat cursul istoriei

Scriitura este superba si surprinde in amanunt trairile presedintelui american din acele vremuri, Franklin D. Roosevelt. Desi tentatiile de a romanta si contura anumite momente probabil i-au dat tarcoale istoricului M.

Via Bogdan Cercel
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Bogdan Cercel's curator insight, August 30, 2013 11:47 AM

recenzie bookuria.info

Rescooped by stoian ioan from Cap Limpede
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SASE persoane cunoscute care au fost pur si simplu STERSE din istorie! FOTO

SASE persoane cunoscute care au fost pur si simplu STERSE din istorie! FOTO | bibliofilie | Scoop.it

Statele totalitare nu agreeaza opozantii, care sunt amenintati sau chiar ucisi, fiind stersi complet din istorie. Te-ai intrebat vreodata cine sunt SOTIILE celor mai cunoscuti DICTATORI ai lumii? V...


Via CapLimpede
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