Autoimmune diseases (Lupus, RA), Vaccines and Stem Cell Therapies Highlights
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Autoimmune diseases (Lupus, RA), Vaccines and Stem Cell Therapies Highlights
Belimumab (Benlysta, HGSI, GSK) is the first new drug approved by the FDA during the last 50 years to treat Lupus or SLE. The EU expert panel has recommended its approval by the EMA. The EMA gave the MAA approval last friday.
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Belimumab (Benlysta, HGSI, GSK) Lupus Review - Krishan Maggon

Belimumab (Benlysta, HGSI, GSK) Lupus Review - Krishan Maggon | Autoimmune diseases (Lupus, RA), Vaccines and Stem Cell Therapies Highlights | Scoop.it
No new drug has been approved to treat Lupus during the past 50 years. Belimumab is one of the rare new biologics to complete Phase III trials with positive outcome. It has now been approved both in the US and EU.
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Gilbert C FAURE's comment, December 14, 2013 3:14 AM
nice ti illustrate with LBT
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Growing blood stem cells in the lab | Eurostemcell

Growing blood stem cells in the lab | Eurostemcell | Autoimmune diseases (Lupus, RA), Vaccines and Stem Cell Therapies Highlights | Scoop.it
Researchers generated blood stem cells and progenitor cells (shown) from human pluripotent stem cells.Image Credit: Rio Sugimura, Daley Lab, Boston Children’s Hospital and Harvard Medical School, 2017by Emma Laycock
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What Are Cancer Stem Cells » Stemtek Therapeutics

What Are Cancer Stem Cells » Stemtek Therapeutics | Autoimmune diseases (Lupus, RA), Vaccines and Stem Cell Therapies Highlights | Scoop.it
Cancer stem cell are capable of recreating itself and multiplying, and controls the growth of the tumor.
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Induction of Regulatory T Cells and Its Regulation with Insulin-like Growth Factor/Insulin-like Growth Factor Binding Protein-4 by Human Mesenchymal Stem Cells

Induction of Regulatory T Cells and Its Regulation with Insulin-like Growth Factor/Insulin-like Growth Factor Binding Protein-4 by Human Mesenchymal Stem Cells | Autoimmune diseases (Lupus, RA), Vaccines and Stem Cell Therapies Highlights | Scoop.it
Human mesenchymal stem cells (MSCs) are multipotent and exert anti-inflammatory effects, but the underlying mechanism remains to be elucidated. In the current study, we investigated the regulatory mechanism of regulatory T cell (Treg) induction through the growth factors released by human MSCs. Human naive CD4+ T cells were stimulated with anti-CD3/28 Abs and cocultured with human MSC culture supernatant for 48 h. The proliferation and cytokine production of CD4+ T cells and surface molecule expression on CD4+ T cells were evaluated. The proliferation of anti-CD3/28 Abs–stimulated CD4+ T cells was suppressed by the addition of human MSC culture supernatant; in addition, the production of IL-10 and IL-4 increased. The human MSC culture supernatant induced CD4+FOXP3+ Tregs that expressed CD25, CTLA-4, glucocorticoid-induced TNFR-related protein, insulin-like growth factor (IGF)-1R, and IGF-2R, showing antiproliferative activity against CD4+ T cells. In addition, the induction of Tregs by human MSC culture supernatant was enhanced by the addition of IGF and suppressed by the inhibition of IGF-1R. In contrast, a significant amount of IGF binding protein (IGFBP)-4, an inhibitor of IGF action, was detected in the human MSC culture supernatant. After neutralization of IGFBP-4 in the human MSC culture supernatant by anti–IGFBP-4 Ab, Treg numbers increased significantly. Thus, our results raise the possibility that human MSC actions also involve a negative-regulatory mechanism that suppresses Treg proliferation by releasing IGFBP-4. The results of this study suggest that regulation of IGF may be important for treatments using human MSCs.
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Efficiency and Safety of CRAC Inhibitors in Human Rheumatoid Arthritis Xenograft Models

Efficiency and Safety of CRAC Inhibitors in Human Rheumatoid Arthritis Xenograft Models | Autoimmune diseases (Lupus, RA), Vaccines and Stem Cell Therapies Highlights | Scoop.it
Store-operated Ca2+ release–activated Ca2+ (CRAC) channels are involved in the pathogenesis of rheumatoid arthritis (RA) and have been studied as therapeutic targets in the management of RA. We investigated the efficacy and safety of CRAC inhibitors, including a neutralizing Ab (hCRACM1-IgG) and YM-58483, in the treatment of RA. Patient-derived T cell and B cell activity was suppressed by hCRACM1-IgG as well as YM-58483. Systemically constant, s.c. infused CRAC inhibitors showed anti-inflammatory activity in a human-NOD/SCID xenograft RA model as well as protective effects against the destruction of cartilage and bone. hCRACM1-IgG appeared to be safe for systemic application, whereas YM-58483 showed hepatic and renal toxicity in xenograft mice. Treatment with both CRAC inhibitors also caused hyperglycemia in xenograft mice. These results indicate the potential of hCRACM1-IgG and YM-58483 as anti-immunological agents for the treatment of RA. However, some safety issues should be addressed and application methods should be optimized prior to their clinical use.
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Rubius Erythrocyte Design (RED)™ Platform for Red-Cell Therapeutics™

Rubius Erythrocyte Design (RED)™ Platform for Red-Cell Therapeutics™ | Autoimmune diseases (Lupus, RA), Vaccines and Stem Cell Therapies Highlights | Scoop.it

OUR PLATFORM


Rubius Therapeutics is using breakthrough science to develop an entirely new class of drugs with the potential to treat many areas of human disease. The Rubius Erythrocyte Design (RED)™ platform enables Rubius scientists to genetically modify, culture and mature hematopoietic stem cells to create allogeneic, functionalized Red-Cell Therapeutics™.

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Diagnosing and attributing neuropsychiatric events to systemic lupus erythematosus: time to untie the Gordian knot? | Rheumatology | Oxford Academic

Diagnosing and attributing neuropsychiatric events to systemic lupus erythematosus: time to untie the Gordian knot? | Rheumatology | Oxford Academic | Autoimmune diseases (Lupus, RA), Vaccines and Stem Cell Therapies Highlights | Scoop.it
Neurological and psychiatric syndromes, collectively referred to as NPSLE, occur frequently in SLE. The frequency of NPSLE varies from 21 to 95%; however, only 13–38% of neuropsychiatric (NP) events could be attributable to SLE in the NPSLE SLICC inception cohort. This variability in the frequency of NPSLE is attributable to the low specificity of the ACR case definitions for SLE-attributed NP syndromes, inclusion of minor NP events in the ACR nomenclature, difficulty in ascertainment of NP events and diverse experience of rheumatologists in the clinical assessment of NP events. Making the correct and early attribution of NP events to SLE is important to institute appropriate immunosuppressive treatment for favourable outcomes. Various attribution models using composite decision rules have been developed and used to ascribe NP events to SLE. This review will focus on the various clinical presentations, diagnostic work-up and attributions of the common NPSLE syndromes, including other NP events not included in the ACR nomenclature but which have come to attention in recent years.
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Ubiquitin-Dependent Regulation of Stem Cell Biology

Ubiquitin-Dependent Regulation of Stem Cell Biology | Autoimmune diseases (Lupus, RA), Vaccines and Stem Cell Therapies Highlights | Scoop.it
The growth of a metazoan body relies on a series of highly coordinated cell-fate decisions
by stem cells which can undergo self-renewal, reversibly enter a quiescent state,
or terminally commit to a cell specification program. To guide their decisions, stem
cells make frequent use of ubiquitylation, a post-translational modification that
can affect the activity, interaction landscape, or stability of stem cell proteins.
In this review we discuss novel findings that have provided insight into ubiquitin-dependent
mechanisms of stem cell control and revealed how an essential and highly conserved
protein modification can shape metazoan development.
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Biomarkers of Human Pluripotent Stem Cell-Derived Cardiac Lineages

Biomarkers of Human Pluripotent Stem Cell-Derived Cardiac Lineages | Autoimmune diseases (Lupus, RA), Vaccines and Stem Cell Therapies Highlights | Scoop.it
Human pluripotent stem cells (hPSCs) offer a practical source for the de novo generation
of cardiac tissues and a unique opportunity to investigate cardiovascular lineage
commitment. Numerous strategies have focused on the in vitro production of cardiomyocytes,
smooth muscle, and endothelium from hPSCs. However, these differentiation protocols
often yield undesired cell types. Thus, establishing a set of stage-specific markers
for pure cardiac subpopulations will assist in defining the hierarchy of cardiac differentiation,
aid in the development of cellular therapy, and facilitate drug screening and disease
modeling.
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Preclinical studies for a phase 1 clinical trial of autologous hematopoietic stem cell gene therapy for sickle cell disease

Preclinical studies for a phase 1 clinical trial of autologous hematopoietic stem cell gene therapy for sickle cell disease | Autoimmune diseases (Lupus, RA), Vaccines and Stem Cell Therapies Highlights | Scoop.it
Gene therapy by autologous hematopoietic stem cell transplantation (HSCT) represents
a new approach to treat sickle cell disease (SCD). Optimization of the manufacture,
characterization and testing of the transduced hematopoietic stem cell final cell
product (FCP), as well as an in depth in vivo toxicology study, are critical for advancing
this approach to clinical trials.
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Stem Cell Therapy for Autism, Autistic Patient Treatment

Stem Cell Therapy for Autism, Autistic Patient Treatment | Autoimmune diseases (Lupus, RA), Vaccines and Stem Cell Therapies Highlights | Scoop.it
Autism and Autistic Spectrum Disorder is a group of complex brain developmental disorders characterized by difficulties in social interactions, communication associated with the abnormal repetitive behaviour, intellectual disabilities, difficulties in motor coordination, attention etc.
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Manufacture of Autologous CD34+ Selected Grafts in the NIAID-Sponsored HALT-MS and SCOT Multicenter Clinical Trials for Autoimmune Diseases

Manufacture of Autologous CD34+ Selected Grafts in the NIAID-Sponsored HALT-MS and SCOT Multicenter Clinical Trials for Autoimmune Diseases | Autoimmune diseases (Lupus, RA), Vaccines and Stem Cell Therapies Highlights | Scoop.it
To ensure comparable grafts for autologous hematopoietic cell transplantation (HCT)
in the National Institute of Allergy and Infectious Diseases–sponsored Investigational
New Drug protocols for multiple sclerosis (HALT-MS) and systemic sclerosis (SCOT),
a Drug Master File approach to control manufacture was implemented, including a common
Master Production Batch Record and site-specific standard operating procedures with
“Critical Elements.” We assessed comparability of flow cytometry and controlled rate
cryopreservation among sites and stability of cryopreserved grafts using hematopoietic
progenitor cells (HPCs) from healthy donors.
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Towards Transformative Therapies for Sickle Cell Disease | The New York Academy of Sciences

Towards Transformative Therapies for Sickle Cell Disease | The New York Academy of Sciences | Autoimmune diseases (Lupus, RA), Vaccines and Stem Cell Therapies Highlights | Scoop.it
This symposium will explore recent developments in the field including elucidation of biological mechanisms of disease and cutting-edge clinical science, while underscoring the importance of the patient experience.
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Eli Lilly Partners with German Biotech Topas Therapeutics Against Autoimmune Disease

Eli Lilly Partners with German Biotech Topas Therapeutics Against Autoimmune Disease | Autoimmune diseases (Lupus, RA), Vaccines and Stem Cell Therapies Highlights | Scoop.it

The European Biotech News Website


Topas Therapeutics has signed a multi-year agreement with Eli Lilly to develop drug candidates for antigen-specific immunotherapy. 


 The young Topas Therapeutics, a spin off from Evotec launched just last year, has managed to sign a research collaboration deal with big pharma Eli Lilly. The partners will work together on selecting external antigens that induce inflammation and autoimmune disease and conduct preclinical studies to identify drug candidates.

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Modelling clinical systemic lupus erythematosus: similarities, differences and success stories | Rheumatology | Oxford Academic

Modelling clinical systemic lupus erythematosus: similarities, differences and success stories | Rheumatology | Oxford Academic | Autoimmune diseases (Lupus, RA), Vaccines and Stem Cell Therapies Highlights | Scoop.it
Mouse models of SLE have been indispensable tools to study disease pathogenesis, to identify genetic susceptibility loci and targets for drug development, and for preclinical testing of novel therapeutics. Recent insights into immunological mechanisms of disease progression have boosted a revival in SLE drug development. Despite promising results in mouse studies, many novel drugs have failed to meet clinical end points. This is probably because of the complexity of the disease, which is driven by polygenic predisposition and diverse environmental factors, resulting in a heterogeneous clinical presentation. Each mouse model recapitulates limited aspects of lupus, especially in terms of the mechanism underlying disease progression. The main mouse models have been fairly successful for the evaluation of broad-acting immunosuppressants. However, the advent of targeted therapeutics calls for a selection of the most appropriate model(s) for testing and, ultimately, identification of patients who will be most likely to respond.
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α-Toxin Regulates Local Granulocyte Expansion from Hematopoietic Stem and Progenitor Cells in Staphylococcus aureus–Infected Wounds

α-Toxin Regulates Local Granulocyte Expansion from Hematopoietic Stem and Progenitor Cells in Staphylococcus aureus–Infected Wounds | Autoimmune diseases (Lupus, RA), Vaccines and Stem Cell Therapies Highlights | Scoop.it
The immune response to Staphylococcus aureus infection in skin involves the recruitment of polymorphonuclear neutrophils (PMNs) from the bone marrow via the circulation and local granulopoiesis from hematopoietic stem and progenitor cells (HSPCs) that also traffic to infected skin wounds. We focus on regulation of PMN number and function and the role of pore-forming α-toxin (AT), a virulence factor that causes host cell lysis and elicits inflammasome-mediated IL-1β secretion in wounds. Infection with wild-type S. aureus enriched in AT reduced PMN recruitment and resulted in sustained bacterial burden and delayed wound healing. In contrast, PMN recruitment to wounds infected with an isogenic AT-deficient S. aureus strain was unimpeded, exhibiting efficient bacterial clearance and hastened wound resolution. HSPCs recruited to infected wounds were unaffected by AT production and were activated to expand PMN numbers in proportion to S. aureus abundance in a manner regulated by TLR2 and IL-1R signaling. Immunodeficient MyD88-knockout mice infected with S. aureus experienced lethal sepsis that was reversed by PMN expansion mediated by injection of wild-type HSPCs directly into wounds. We conclude that AT-induced IL-1β promotes local granulopoiesis and effective resolution of S. aureus –infected wounds, revealing a potential antibiotic-free strategy for tuning the innate immune response to treat methicillin-resistant S. aureus infection in immunodeficient patients.
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Differences in Stem Cell Processing Lead to Distinct Secretomes Secretion—Implications for Differential Results of Previous Clinical Trials of Stem Cell Therapy for Myocardial Infarction

Differences in Stem Cell Processing Lead to Distinct Secretomes Secretion—Implications for Differential Results of Previous Clinical Trials of Stem Cell Therapy for Myocardial Infarction | Autoimmune diseases (Lupus, RA), Vaccines and Stem Cell Therapies Highlights | Scoop.it
Stem cell therapy for acute myocardial infarction (AMI) seemed to be a promising therapy, however, large clinical trials brought differential outcome. It has been shown that paracrine effects o
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Long-term clinical and immunological effects of probiotic and peanut oral immunotherapy after treatment cessation: 4-year follow-up of a randomised, double-blind, placebo-controlled trial

Long-term clinical and immunological effects of probiotic and peanut oral immunotherapy after treatment cessation: 4-year follow-up of a randomised, double-blind, placebo-controlled trial | Autoimmune diseases (Lupus, RA), Vaccines and Stem Cell Therapies Highlights | Scoop.it
PPOIT provides long-lasting clinical benefit and persistent suppression of the allergic
immune response to peanut.
Krishan Maggon 's insight:
Long-term clinical and immunological effects of probiotic and peanut oral immunotherapy after treatment cessation: 4-year follow-up of a randomised, double-blind, placebo-controlled trial DOI: http://dx.doi.org/10.1016/S2352-4642(17)30041-X
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Upregulation of CD16− monocyte subsets in systemic lupus erythematous patients

Upregulation of CD16− monocyte subsets in systemic lupus erythematous patients | Autoimmune diseases (Lupus, RA), Vaccines and Stem Cell Therapies Highlights | Scoop.it
Monocytes are an important component in the innate immune system. However, studies to date have failed to conclude whether their levels are altered in patients with systemic lupus erythematosus (SLE).
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Mammary Stem Cells: Premise, Properties, and Perspectives

Mammary Stem Cells: Premise, Properties, and Perspectives | Autoimmune diseases (Lupus, RA), Vaccines and Stem Cell Therapies Highlights | Scoop.it
Adult mammary stem cells (MaSCs) drive postnatal organogenesis and remodeling in the
mammary gland, and their longevity and potential have important implications for breast
cancer. However, despite intense investigation the identity, location, and differentiation
potential of MaSCs remain subject to deliberation. The application of genetic lineage-tracing
models, combined with quantitative 3D imaging and biophysical methods, has provided
new insights into the mammary epithelial hierarchy that challenge classical definitions
of MaSC potency and behaviors.
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Mesenchymal stem cell in venous leg ulcer: An intoxicating therapy

Mesenchymal stem cell in venous leg ulcer: An intoxicating therapy | Autoimmune diseases (Lupus, RA), Vaccines and Stem Cell Therapies Highlights | Scoop.it
Venous leg ulcers (VLU) are a prevalent and reoccurring type of complicated wound,
turning as a considerable public healthcare issue, with critical social and economic
concern. There are both medical and surgical therapies to treat venous leg ulcers;
however, a cure does not yet exist. Mesenchymal stem cells (MSC) are capable and proved
of accelerating wound healing in vivo and their study with human chronic wounds is
currently awaited. MSCs are a promising source of adult progenitor cells for cellular
therapy and have been demonstrated to differentiate into various mesenchymal cell
lineages.
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Complement C5a induces mesenchymal stem cell apoptosis during the progression of chronic diabetic complications

Complement C5a induces mesenchymal stem cell apoptosis during the progression of chronic diabetic complications | Autoimmune diseases (Lupus, RA), Vaccines and Stem Cell Therapies Highlights | Scoop.it
Regeneration and repair mediated by mesenchymal stem cells (MSCs) are key self-protection mechanisms against diabetic complications, a reflection of diabetes-related cell/tissue damage and dysfunction
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Induced Pluripotent Stem Cells in Cardiovascular Precision Medicine

Induced Pluripotent Stem Cells in Cardiovascular Precision Medicine | Autoimmune diseases (Lupus, RA), Vaccines and Stem Cell Therapies Highlights | Scoop.it
Induced pluripotent stem cells (iPSCs), derived from somatic cells obtained from human subjects, can be used for disease modelling, drug screening, and regenerative therapy.
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Regulation of Stem Cell Aging by Metabolism and Epigenetics

Regulation of Stem Cell Aging by Metabolism and Epigenetics | Autoimmune diseases (Lupus, RA), Vaccines and Stem Cell Therapies Highlights | Scoop.it
In this issue of Cell Metabolism, Ren et al. discuss the current knowledge regarding
the metabolic-epigenetic axis regulating stem cell aging in response to environmental
stimuli. In addition, the authors highlight recent therapeutic strategies aiming at
the rejuvenation of aged stem cells.
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Brain stem cells unintentionally talk with brain tumors, allowing their spread

Brain stem cells unintentionally talk with brain tumors, allowing their spread | Autoimmune diseases (Lupus, RA), Vaccines and Stem Cell Therapies Highlights | Scoop.it
A stem cell’s capacity to lay quiet and, when needed, to self-renew plays a key role in restoring and maintaining the health of our organs. Unfortunately, cancer stem cells possess that same property allowing them to evade radiation and chemotherapy treatments which leads to tumor regrowth. And a CIRM-funded study published today in Cell shows…
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Are stem cells the link between bacteria and cancer?

Are stem cells the link between bacteria and cancer? | Autoimmune diseases (Lupus, RA), Vaccines and Stem Cell Therapies Highlights | Scoop.it
Gastric carcinoma is one of the most common causes of cancer-related deaths, primarily because most patients present at an advanced stage of the disease. The main cause of this cancer is the bacterium Helicobacter pylori
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