BEDSIDE CLINICS
5 views | +0 today
Follow
Your new post is loading...
Your new post is loading...
Rescooped by Dr. KGM BIYABANI from Heart and Vascular Health
Scoop.it!

Lower Your Triglycerides with Lifestyle

Triglycerides (TGs) are a type of fat in the bloodstream. They are used for energy. When TGs become too high, this biomarker
suggests risk for cardiovascular disease, especially when accompanied by low HDL-cholesterol and high LDL-cholesterol. High
triglycerides are a common problem in the United States. One third of adults have levels above the normal range (< 150 mg/dl).
The good news about TGs is that they are highly responsive to lifestyle modifications. Optimal lifestyle interventions can lower
TGs by 20-50%. We suggest that you look at the following chart and select a change or changes you feel ready to make!
Note: When evaluating TG levels over time, be aware that there is considerable variability in the measurement of TG. Look at
the trend in TG over time (not just one reading) to evaluate the success of your lifestyle changes. Remember, the same positive
lifestyle changes that lower TG, also improve your overall health!


Via Seth Bilazarian, MD
more...
Seth Bilazarian, MD's curator insight, March 24, 2014 2:20 PM

Nice resource from National Lipid Association on therapeutic lifestyle changes that reduce triglycerides.  PDF tear sheet.

Rescooped by Dr. KGM BIYABANI from BEDSIDE CLINICS
Scoop.it!

Diminishing Returns of Modern Medicine - fight to shave minutes in heart attack care

Diminishing Returns of Modern Medicine - fight to shave minutes in heart attack care | BEDSIDE CLINICS | Scoop.it
In-hospital mortality after an acute heart attack has dropped 10-fold, from 30 percent to 3 percent, since the invention of the modern cardiac care unit in the 1960s. Can shaving a few more minutes off the time it takes to get hospital treatment possibly yield any additional benefit?

Via Seth Bilazarian, MD, Dr. KGM BIYABANI
more...
Seth Bilazarian, MD's curator insight, March 20, 2014 2:07 PM

This is a good account of the problem with advancing medicine.  As we reduce bad outcomes closer to zero OF COURSE there is going to be much greater difficulty (this is the high hanging fruit)..  The author is right that because of the pressure of public reporting on door to balloon time (D2BT) sometimes decisions are rushed and this is an area of concern.

The example he provides of the cardiologist driving 90 mph is not appropriate because that is an example of a system problem that SHOULD be fixed.  Taking 60 minutes to figure out a patient has a heat attack is much to long and not good care.

Rescooped by Dr. KGM BIYABANI from Heart and Vascular Health
Scoop.it!

Diminishing Returns of Modern Medicine - fight to shave minutes in heart attack care

Diminishing Returns of Modern Medicine - fight to shave minutes in heart attack care | BEDSIDE CLINICS | Scoop.it
In-hospital mortality after an acute heart attack has dropped 10-fold, from 30 percent to 3 percent, since the invention of the modern cardiac care unit in the 1960s. Can shaving a few more minutes off the time it takes to get hospital treatment possibly yield any additional benefit?

Via Seth Bilazarian, MD
more...
Seth Bilazarian, MD's curator insight, March 20, 2014 2:07 PM

This is a good account of the problem with advancing medicine.  As we reduce bad outcomes closer to zero OF COURSE there is going to be much greater difficulty (this is the high hanging fruit)..  The author is right that because of the pressure of public reporting on door to balloon time (D2BT) sometimes decisions are rushed and this is an area of concern.

The example he provides of the cardiologist driving 90 mph is not appropriate because that is an example of a system problem that SHOULD be fixed.  Taking 60 minutes to figure out a patient has a heat attack is much to long and not good care.

Rescooped by Dr. KGM BIYABANI from BEDSIDE CLINICS
Scoop.it!

Lower Your Triglycerides with Lifestyle

Triglycerides (TGs) are a type of fat in the bloodstream. They are used for energy. When TGs become too high, this biomarker
suggests risk for cardiovascular disease, especially when accompanied by low HDL-cholesterol and high LDL-cholesterol. High
triglycerides are a common problem in the United States. One third of adults have levels above the normal range (< 150 mg/dl).
The good news about TGs is that they are highly responsive to lifestyle modifications. Optimal lifestyle interventions can lower
TGs by 20-50%. We suggest that you look at the following chart and select a change or changes you feel ready to make!
Note: When evaluating TG levels over time, be aware that there is considerable variability in the measurement of TG. Look at
the trend in TG over time (not just one reading) to evaluate the success of your lifestyle changes. Remember, the same positive
lifestyle changes that lower TG, also improve your overall health!


Via Seth Bilazarian, MD, Dr. KGM BIYABANI
more...
Seth Bilazarian, MD's curator insight, March 24, 2014 2:20 PM

Nice resource from National Lipid Association on therapeutic lifestyle changes that reduce triglycerides.  PDF tear sheet.

Rescooped by Dr. KGM BIYABANI from Heart and Vascular Health
Scoop.it!

Diminishing Returns of Modern Medicine - fight to shave minutes in heart attack care

Diminishing Returns of Modern Medicine - fight to shave minutes in heart attack care | BEDSIDE CLINICS | Scoop.it
In-hospital mortality after an acute heart attack has dropped 10-fold, from 30 percent to 3 percent, since the invention of the modern cardiac care unit in the 1960s. Can shaving a few more minutes off the time it takes to get hospital treatment possibly yield any additional benefit?

Via Seth Bilazarian, MD
more...
Seth Bilazarian, MD's curator insight, March 20, 2014 2:07 PM

This is a good account of the problem with advancing medicine.  As we reduce bad outcomes closer to zero OF COURSE there is going to be much greater difficulty (this is the high hanging fruit)..  The author is right that because of the pressure of public reporting on door to balloon time (D2BT) sometimes decisions are rushed and this is an area of concern.

The example he provides of the cardiologist driving 90 mph is not appropriate because that is an example of a system problem that SHOULD be fixed.  Taking 60 minutes to figure out a patient has a heat attack is much to long and not good care.

Rescooped by Dr. KGM BIYABANI from GenoCon 2
Scoop.it!

PBS NewsHour - Google+ - John B. Gurdon and Shinya Yamanaka share this year's Nobel…

PBS NewsHour - Google+ - John B. Gurdon and Shinya Yamanaka share this year's Nobel… | BEDSIDE CLINICS | Scoop.it
John B.Gurdon and Shinya Yamanaka share this year's Nobel Prize in Medicine and Physiology for their work in cellular reprogramming, 50 years after…...

How Yamanaka-san and Sir John Gurdon came to their idea! 

http://www.pbs.org/newshour/rundown/2012/10/-in-1962-john-b.html

 

Nobel Prize winner Sir John Gurdon talks to reporters on Oct. 8, 2012 in London. Gurdon and Shinya Yamanaka from Japan have both been awarded the Nobel prize for medicine or physiology for their work as pioneers of stem cell research. Photo by Peter Macdiarmid/Getty Images.

 

In 1962, John B. Gurdon of the United Kingdom discovered that a cell removed from the gut of a frog contained all the genetic information necessary to create the whole frog. More than 40 years later, Shinya Yamanaka of Japan found that by introducing a few genes to a mature mouse cell, he could reprogram it into a stem cell, capable of developing into any cell in the body.

 

Gurdon and Yamanaka share this year's Nobel Prize in Physiology or Medicine for their work in cellular reprogramming, 50 years after Gurdon's initial discovery. Their work in stem cells has led to a wave of advances, from cloning animals to allowing scientists to create embryonic cells without having to destroy embryos.

 

Gurdon was still a graduate student when he first transplanted genetic information from the nucleus of an intestinal cell of one frog into the fertilized egg cell of another whose own nucleus had been removed. That cell was able to reprogram and develop into a tadpole, proving that even mature, specialized cells have all the information needed to transform an embryo into an adult.

 

He relied on a technique called nuclear transfer to transplant the nuclei. The discovery flew in the face of established opinion, since other more established scientists hadn't been able to successfully make such a transfer, and it was thought then that a specialized cell is irreversibly tied to its fate.

 

"We had to go through a few years, in a sense, of letting the results sink in," Gurdon said in an early morning interview with the Nobel committee.

 

The same year that discovery was published, Yamanaka was born. And 40 years later, he took the science a big step farther. His research identified the four genes that made it possible to reverse mature stem cells into their embryonic state without using nuclear transfer. The "induced pluripotent embryonic stem cells" could then go on to become nerve cells, heart cells, gut cells.

That finding opened the possibility for skin cells to be reversed to embryonic cells and then reprogrammed into nerve, heart or other tissue cells for medical uses and disease treatment. Such reprogrammed cells have not yet been used to treat patients.

 

"They showed us that it is not a one-way street, that a cell retains the ability to go back to what it was in a primordial state, that it could rewind all its potential," said David Scadden of the Harvard Stem Cell Institute. "What that means is...what we think of as highly restricted has the capacity to become any other cell. If we can engineer that process, that opens up new possibilities for regenerative medicine."

 

And that's Yamanaka's goal.

"My goal all my life is to bring this stem cell technology to the bedside, to patients, to clinics," Yamanaka told Adam Smith, editorial director of Nobel Media early Monday morning.

In this interview with KQED's Quest, Yamanaka talks about his recent research using stem cell-derived nerve cells to treat animals with spinal cord injuries.

 

(the video in the link) http://youtu.be/rcFibJmKZrU

 

Gurdon told Nobel Media's Smith that the finding highlights the importance of basic science, even if there isn't an immediate benefit to health.

 

"So often it happens that the practical or theraupeutic benefits comes along quite a long time after the initial discovery," he said.

NewsHour correspondent Spencer Michels featured Yamanaka in this 2007 report on stem cell research.

http://www.pbs.org/newshour/bb/health/july-dec07/stemcell_10-08.html

 

Here's a story by KQED's Quest on the discovery. 

http://science.kqed.org/quest/2012/10/08/sf-scientist-wins-nobel-for-stem-cell-breakthrough/

 


Via David Gifford
more...
No comment yet.