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Neuroscience thinks big (and collaboratively)

Despite cash-strapped times for research, several ambitious collaborative neuroscience projects have attracted large amounts of funding and media attention. In Europe, the Human Brain Project aims to develop a large-scale computer simulation of the brain, whereas in the United States, the Brain Activity Map is working towards establishing a functional connectome of the entire brain, and the Allen Institute for Brain Science has embarked upon a 10-year project to understand the mouse visual cortex (the MindScope project). US President Barack Obama's announcement of the BRAIN Initiative (Brain Research through Advancing Innovative Neurotechnologies Initiative) in April 2013 highlights the political commitment to neuroscience and is expected to further foster interdisciplinary collaborations, accelerate the development of new technologies and thus fuel much needed medical advances. In this Viewpoint article, five prominent neuroscientists explain the aims of the projects and how they are addressing some of the questions (and criticisms) that have arisen. - by Kandel ER et al., Nature Reviews Neuroscience 14, 659–664 (2013) 


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Brain spikes: Synchrony may be key to cracking brain's neural code

Brain spikes: Synchrony may be key to cracking brain's neural code | Be Your Whole Self | Scoop.it

In a perspective article published in the journal Nature Neuroscience on Feb. 25, 2013, biomedical engineering professor Garrett Stanley detailed research progress toward "reading and writing the neural code." This encompasses the ability to observe the spiking activity of neurons in response to outside stimuli and make clear predictions about what is being seen, heard, or felt, and the ability to artificially introduce activity within the brain that enables someone to see, hear, or feel something that is not experienced naturally through sensory organs.(...) - Science Dailay, March 12, 2013tti


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Julien Hering, PhD's curator insight, March 22, 2013 6:57 AM

Journal Reference:


Garrett B Stanley. Reading and writing the neural code.Nature Neuroscience, 2013; 16 (3): 259 DOI:10.1038/nn.3330

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Whole brain cellular-level activity mapping in a second

Whole brain cellular-level activity mapping in a second | Be Your Whole Self | Scoop.it

It is now possible to map the activity of nearly all the neurons in a vertebrate brain at cellular resolution. What does this mean for neuroscience research and projects like the Brain Activity Map proposal?

In an Article that just went live in Nature Methods, Misha Ahrens and Philipp Keller from HHMI’s Janelia Farm Research Campus used high-speed light sheet microscopy to image the activity of 80% of the neurons in the brain of a fish larva at speeds of a whole brain every 1.3 seconds. This represents—to our knowledge—the first technology that achieves whole brain imaging of a vertebrate brain at cellular resolution with speeds that approximate neural activity patterns and behavior. (...) - by erika pastrana, Nature Methods, 18 Mar 2013


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