Baclofen - Medical Resources
86 views | +0 today
Follow
Baclofen - Medical Resources
Baclofen medical resources, clinical trials, research about Baclofen, Cure for alcoholism, Baclofen for addictions
Curated by Baclofen
Your new post is loading...
Your new post is loading...
Scooped by Baclofen
Scoop.it!

★ High-Dose Baclofen for the Treatment of Alcohol Dependence (BACLAD study): A Randomized, Placebo-Controlled Trial

Baclofen's insight:

"These results provide further evidence for the potential of baclofen, thereby possibly extending the current pharmacological treatment options in alcohol dependence."

more...
No comment yet.
Scooped by Baclofen
Scoop.it!

Open Study in Belgium: Baclofen in the treatment of #alcoholism

Baclofen's insight:

Open Study in Belgium: Baclofen in the treatment of alcoholism

more...
No comment yet.
Scooped by Baclofen
Scoop.it!

BACLOFENE LEADS TO ALCOHOL CONSUMPTION REDUCTION AND HEPATIC IMPROVEMENT IN CIRRHOTIC PATIENTS

BACLOFENE LEADS TO ALCOHOL CONSUMPTION REDUCTION AND HEPATIC IMPROVEMENT IN CIRRHOTIC PATIENTS | Baclofen - Medical Resources | Scoop.it
EASL LiverTree™, Apr 11 2014, 49044
Baclofen's insight:

9 months follow up

more...
No comment yet.
Scooped by Baclofen
Scoop.it!

Utilization of Baclofen in Maintenance of Alcohol Abstinence in Patients with Alcohol Dependence and Alcoholic Hepatitis with or without Cirrhosis

Utilization of Baclofen in Maintenance of Alcohol Abstinence in Patients with Alcohol Dependence and Alcoholic Hepatitis with or without Cirrhosis | Baclofen - Medical Resources | Scoop.it
Baclofen's insight:

Conclusions: Baclofen's safety and efficacy in improving the clinical condition patients with alcoholic liver disease has been supported. Randomized prospective studies with longer duration of baclofen in this population may further optimize its use and corroborate efficacy.

more...
No comment yet.
Scooped by Baclofen
Scoop.it!

High-dose baclofen for treatment-resistant alcohol dependence [J Clin Psychopharmacol. 2012] - PubMed - NCBI

"...Here, we report on 4 alcohol-dependent patients resistant to standard treatments who responded to higher doses of baclofen ranging from 75 to 125 mg daily. Further research into the use of high-dose baclofen for treatment-resistant alcohol dependence is warranted..."

Baclofen's insight:

High-dose baclofen for treatment-resistant alcohol dependence.

more...
No comment yet.
Scooped by Baclofen
Scoop.it!

2013 - Acute baclofen diminishes resting baseline blood flow to limbic structures: A perfusion fMRI study

2013 - Acute baclofen diminishes resting baseline blood flow to limbic structures: A perfusion fMRI study | Baclofen - Medical Resources | Scoop.it
Baclofen's insight:

"...baclofen may be useful on an as-needed basis to block craving during at risk situations."

 

more...
No comment yet.
Scooped by Baclofen
Scoop.it!

Baclofen Can Ease Symptoms of Acute Alcohol Withdrawal

Baclofen Can Ease Symptoms of Acute Alcohol Withdrawal | Baclofen - Medical Resources | Scoop.it
A short course of baclofen can quickly neutralize alcohol withdrawal symptoms, with fewer risks than standard-of-care treatment.
more...
No comment yet.
Scooped by Baclofen
Scoop.it!

A study of comparative efficacy of Baclofen vs Acamprosate - NOT published in PUBMED!

A study of comparative efficacy of Baclofen vs Acamprosate - NOT published in PUBMED! | Baclofen - Medical Resources | Scoop.it
Baclofen's insight:

The results of the present study confirm that baclofen, because of its anti-craving and anti-reward action on one hand, and safety on the other, has an important role in the treatment of patients with alcohol abuse and dependence.Further in comparison to acamprosate it seems more effective in reducing craving and maintaining abstinence in the short term.

more...
No comment yet.
Scooped by Baclofen
Scoop.it!

The γ-Aminobutyric Acid-B Receptor Agonist Baclofen Attenuates Responding for Ethanol in Ethanol-Dependent Rats

The γ-Aminobutyric Acid-B Receptor Agonist Baclofen Attenuates Responding for Ethanol in Ethanol-Dependent Rats | Baclofen - Medical Resources | Scoop.it
Baclofen's insight:
...2009 study by George F. Koob, PhD actual (2014)  editorial board on Journal of Addiction Medicine...
"As baclofen suppressed ethanol self-administration and showed evidence of increased potency in dependent animals, the present experiment suggests that the GABAB receptor could be a potential pharmacotherapeutic target for the treatment of chronic alcoholism."
more...
No comment yet.
Scooped by Baclofen
Scoop.it!

Novel Therapeutic Strategies for Alcohol and Drug Addiction: Focus on GABA, Ion Channels and Transcranial Magnetic Stimulation

more...
No comment yet.
Scooped by Baclofen
Scoop.it!

Baclofen administration for the treatmen... [Drug Alcohol Depend. 1993] - PubMed - NCBI

PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Baclofen's insight:
Baclofen's insight:

An OLD (1993) medical document proving the efficacy of Baclofen in Russia...
http://www.ncbi.nlm.nih.gov/pubmed/8261880

more...
No comment yet.
Scooped by Baclofen
Scoop.it!

CGP7930: a positive allosteric modulator of the... [CNS Drug Rev. 2007] - PubMed - NCBI

PubMed comprises more than 22 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Baclofen's insight:

...it seem that this modulator of the GABAb is able to potentiate the effects of Baclofen making possible to use less quantity and having the same effects... not the bad ES, just the good of the medicament!

more...
No comment yet.
Scooped by Baclofen
Scoop.it!

Suppression of Alcohol Dependence Using Baclofen: A 2-Year Observational Study of 100 Patients

Suppression of Alcohol Dependence Using Baclofen: A 2-Year Observational Study of 100 Patients | Baclofen - Medical Resources | Scoop.it
Baclofen's insight:

the last important clinical trial about Baclofen, made in France by Dr. R. De Beaurepaire

more...
No comment yet.
Scooped by Baclofen
Scoop.it!

Baclofen As An Adjunct Pharmacotherapy For The Maintenance Of Abstinence In Alcohol Dependent Patients With Liver Disease - Owens et al. 63, Gut - July 2014

Baclofen As An Adjunct Pharmacotherapy For The Maintenance Of Abstinence In Alcohol Dependent Patients With Liver Disease - Owens et al. 63, Gut - July 2014 | Baclofen - Medical Resources | Scoop.it
Baclofen's insight:

Baclofen has a positive impact on alcohol consumption in this very difficult to treat, high risk patient group. A RCT is needed to confirm the benefit of baclofen in this patient group.

more...
No comment yet.
Scooped by Baclofen
Scoop.it!

GABAB receptors as a therapeutic strategy in substance use disorders: Focus on positive allosteric modulators. [Neuropharmacology. 2014]

PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Baclofen's insight:

Moreover, given that anxiolytic effects are also reported with such ligands they may also benefit in mitigating the withdrawal from drugs of abuse. In summary, a wealth of data now supports the benefits of GABAB receptor PAMs and clinical validation is now warranted. This article is part of a Special Issue entitled 'GABAergic signaling'.

more...
No comment yet.
Scooped by Baclofen
Scoop.it!

Intrathecal Baclofen Improves Psychiatric Symptoms in Spasti... : Journal of Clinical Psychopharmacology

Intrathecal Baclofen Improves Psychiatric Symptoms in Spasti... : Journal of Clinical Psychopharmacology | Baclofen - Medical Resources | Scoop.it
AbstractSymptoms of psychological distress are relatively common in spasticity patients as a result either of the primary central nervous system insult or as a reaction to the ensuing impairment. Intrathecal baclofen (ITB) is an established treatment for the spasticity with an unknown effect on t...
Baclofen's insight:

An interesting trend was also noted in the subscales of general severity index, depression, and obsession-compulsion. The results show an additional beneficial effect of ITB and highlight the need of further clarification of the causative mechanism.

more...
No comment yet.
Scooped by Baclofen
Scoop.it!

Baclofen for Addictions - twitter stream

Baclofen for Addictions - twitter stream | Baclofen - Medical Resources | Scoop.it

Baclofen for alcohol addiction (and not only). News and research about a Gabab agonist that helps to beat addiction.

Baclofen's insight:

News constantly updated fron @baclofenews Twitter account.

more...
No comment yet.
Scooped by Baclofen
Scoop.it!

Penn Medicine Points to New Ways to Prevent Relapse in Cocaine-Addicted Patients

Researchers at Penn Medicine’s Center for Studies of Addiction have now found that the drug baclofen, commonly used to prevent spasms in patients with spinal cord injuries and neurological disorders, can help block the impact of the brain’s response to “unconscious” drug triggers well before conscious craving occurs.
more...
No comment yet.
Scooped by Baclofen
Scoop.it!

1991 High-dose oral baclofen: experience in patients with multiple sclerosis [Neurology. 1991] - PubMed - NCBI

"We reviewed a 10% random sample of charts from an outpatient clinic for multiple sclerosis to determine the frequency with which baclofen was prescribed for spasticity in high doses (greater than 80 mg/d). About 20% of patients had taken high-dose baclofen, and 15% were still receiving a high dose. Taking a high dose was not associated with discontinuing treatment."

Baclofen's insight:

High-dose oral baclofen: experience in patients with multiple sclerosis.

more...
No comment yet.
Scooped by Baclofen
Scoop.it!

Baclofen for maintenance treatment of opioid dependence: a randomized double-blind placebo-controlled clinical trial [BMC Psychiatry. 2003] - PubMed - NCBI

The results support further study of baclofen in the maintenance treatment of opioid dependence.

Baclofen's insight:

The results support further study of baclofen in the maintenance treatment of opioid dependence.

more...
No comment yet.
Scooped by Baclofen
Scoop.it!

2007 - Baclofen for binge eating: an open-label trial [Int J Eat Disord. 2007]

PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Baclofen's insight:
CONCLUSION: In this open-label trial, baclofen was associated with decreased binge eating frequency in patients with BED and BN.
more...
No comment yet.
Scooped by Baclofen
Scoop.it!

2002 - A POTENTIAL ROLE FOR GABAB AGONISTS IN THE TREATMENT OF PSYCHOSTIMULANT ADDICTION

2002 - A POTENTIAL ROLE FOR GABAB AGONISTS IN THE TREATMENT OF PSYCHOSTIMULANT ADDICTION | Baclofen - Medical Resources | Scoop.it
Baclofen's insight:

"Results: The results show that systemic pretreatment with baclofen can reduce cocaine intake at doses that do not affect responding for other positive reinforcers, such as food."

more...
No comment yet.
Scooped by Baclofen
Scoop.it!

High Variability in the Exposure of Baclofen... [Alcohol Clin Exp Res. 2013] - PubMed - NCBI

PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
more...
No comment yet.
Scooped by Baclofen
Scoop.it!

Baclofen Add-on to Citalopram in Treatment of Posttraumatic Stress Disorder.[2014] - PubMed - NCBI

PubMed comprises more than 23 million citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Baclofen's insight:

"...Baclofen showed to be an effective add-on to selective serotonin reuptake inhibitors in treatment of PTSD for better symptom recovery and functional improvement..."

more...
No comment yet.
Scooped by Baclofen
Scoop.it!

Novel Therapeutic Strategies for Alcohol and Drug Addiction: Focus on GABA, Ion Channels and Transcranial Magnetic Stimulation

more...
No comment yet.