Avian influenza virus A(H7N9)
497 views | +1 today
Follow
 
Rescooped by Ben van Lier from Viruses and Bioinformatics from Virology.uvic.ca
onto Avian influenza virus A(H7N9)
Scoop.it!

Characterization of H7N9 influenza A viruses isolated from humans

Characterization of H7N9 influenza A viruses isolated from humans | Avian influenza virus A(H7N9) | Scoop.it

Avian influenza A viruses rarely infect humans; however, when human infection and subsequent human-to-human transmission occurs, worldwide outbreaks (pandemics) can result. The recent sporadic infections of humans in China with a previously unrecognized avian influenza A virus of the H7N9 subtype (A(H7N9)) have caused concern owing to the appreciable case fatality rate associated with these infections (more than 25%), potential instances of human-to-human transmission1, and the lack of pre-existing immunity among humans to viruses of this subtype. Here we characterize two early human A(H7N9) isolates, A/Anhui/1/2013 (H7N9) and A/Shanghai/1/2013 (H7N9); hereafter referred to as Anhui/1 and Shanghai/1, respectively. In mice, Anhui/1 and Shanghai/1 were more pathogenic than a control avian H7N9 virus (A/duck/Gunma/466/2011 (H7N9); Dk/GM466) and a representative pandemic 2009 H1N1 virus (A/California/4/2009 (H1N1pdm09); CA04). Anhui/1, Shanghai/1 and Dk/GM466 replicated well in the nasal turbinates of ferrets. In nonhuman primates, Anhui/1 and Dk/GM466 replicated efficiently in the upper and lower respiratory tracts, whereas the replicative ability of conventional human influenza viruses is typically restricted to the upper respiratory tract of infected primates. By contrast, Anhui/1 did not replicate well in miniature pigs after intranasal inoculation. Critically, Anhui/1 transmitted through respiratory droplets in one of three pairs of ferrets. Glycan arrays showed that Anhui/1, Shanghai/1 and A/Hangzhou/1/2013 (H7N9) (a third human A(H7N9) virus tested in this assay) bind to human virus-type receptors, a property that may be critical for virus transmissibility in ferrets. Anhui/1 was found to be less sensitive in mice to neuraminidase inhibitors than a pandemic H1N1 2009 virus, although both viruses were equally susceptible to an experimental antiviral polymerase inhibitor. The robust replicative ability in mice, ferrets and nonhuman primates and the limited transmissibility in ferrets of Anhui/1 suggest that A(H7N9) viruses have pandemic potential.


Via Torben Barsballe
more...
No comment yet.
Your new post is loading...
Your new post is loading...
Scooped by Ben van Lier
Scoop.it!

Signs of drug resistance in bird flu strain after H7N9 kills 94 in China

Drug treatment for the deadly H7N9 strain still effective in China, but research needed quickly into latest mutation of the virus, experts say
more...
No comment yet.
Scooped by Ben van Lier
Scoop.it!

Human cases of H7N9 bird flu are surging, officials say

The H7N9 bird flu virus, which has sickened and killed several hundred people in China, had seemed to be diminishing as a threat.
more...
No comment yet.
Scooped by Ben van Lier
Scoop.it!

Human infection with avian influenza A(H7N9) virus – China

On 18 February 2017, the National Health and Family Planning Commission of China (NHFPC) reported to WHO the results of genetic sequencing on virus isolates from two previously reported cases of human infection with avian influenza A(H7N9) virus from Guangdong province. Changes at the cleavage site of the HA gene suggestive of being highly pathogenic to poultry was confirmed by the Chinese National Influenza Centre of the Chinese Centre for Disease Control and Prevention (China CDC).
more...
No comment yet.
Scooped by Ben van Lier
Scoop.it!

Scientists discover 2 new strains of resistant H7N9 flu in Guangdong - Global Times

Two new flu strains that mutated from H7N9 patients in South China's Guangdong Province have been discovered which are resistant to existing medications, an expert on respiratory disease revealed at a conference on Saturday.

more...
No comment yet.
Scooped by Ben van Lier
Scoop.it!

Man dies from H7N9 infection 丨 Nation

RT @ChinaDailyAsia: Man, 60, dies from #H7N9 bird flu in Guangxi #China
https://t.co/4x4kxdKAXv https://t.co/eSMOya66gR
more...
No comment yet.
Scooped by Ben van Lier
Scoop.it!

East China's Jiangxi reports two more H7N9 cases - China - Chinadaily.com.cn

Two more human infections of H7N9 bird flu were reported in East China's Jiangxi province, bringing total number of infections to 30 in the province this year.
more...
No comment yet.
Scooped by Ben van Lier
Scoop.it!

#China, #Henan province reported three #human cases of #H7N9 #influenza in the last nine days (Feb. 25 ‘17)

Infectious Diseases and Emerging Threats tracking and monitoring blog
more...
No comment yet.
Scooped by Ben van Lier
Scoop.it!

#China, #Guangxi reported a #fatal #human #infection with #H7N9 #influenza (Feb. 25 ‘17)

Infectious Diseases and Emerging Threats tracking and monitoring blog
more...
No comment yet.
Scooped by Ben van Lier
Scoop.it!

CHP notified of human cases of avian influenza A(H7N9) in Mainland

The Centre for Health Protection (CHP) of the Department of Health today (February 25) received notification from the National Health and Family Planning Commission that 2
more...
No comment yet.
Scooped by Ben van Lier
Scoop.it!

#China, #Henan Province reported three #human cases of #H7N9 #influenza the last week (Feb. 24 ‘17)

Infectious Diseases and Emerging Threats tracking and monitoring blog
more...
No comment yet.
Scooped by Ben van Lier
Scoop.it!

ECDC: Mutation of avian influenza A(H7N9)

ECDC has published a review: Mutation of avian influenza A(H7N9): now highly pathogenic for poultry but risk of human-to-human transmission remains low. Excerpt: On 22 February 2017, WHO published the updated cumulative number of human cases of avian influenz
more...
No comment yet.
Scooped by Ben van Lier
Scoop.it!

#China, #Shandong: a #human case of #influenza #H7N9 detected in #Tengzhou (Feb. 23 ‘17)

Infectious Diseases and Emerging Threats tracking and monitoring blog
more...
No comment yet.
Scooped by Ben van Lier
Scoop.it!

China - Guizhou province reports one new H7N9 avian flu case - February 22, 2017 - FluTrackers News and Information

China: Guizhou reported an additional human H7N9 Avian flu case in Qiandongnan Opened by: the Medical health institution of Qiandongnan Miao and Dong autonomous
more...
No comment yet.
Scooped by Ben van Lier
Scoop.it!

WHO: Human infection with HPAI H7N9 | Infectious Diseases 2017 | Infectious diseases | Poultrymed

27 February, 2017 On 18 February 2017, the National Health and Family Planning Commission of China (NHFPC) reported to WHO the results of genetic sequencing on virus isolates from two previously reported cases of human infection with avian influenza A(H7N9) virus from Guangdong province.
more...
No comment yet.
Scooped by Ben van Lier
Scoop.it!

#Taiwan, the first imported #human case of #H7N9 #influenza of the year died (RTHK, Feb. 28 ‘17)

Infectious Diseases and Emerging Threats tracking and monitoring blog
more...
No comment yet.
Scooped by Ben van Lier
Scoop.it!

#China, the third #human case of #H7N9 #influenza in #Shenzhen had exposure to #poultry before illness onset (Feb. 27 ‘17)

Infectious Diseases and Emerging Threats tracking and monitoring blog
more...
No comment yet.
Scooped by Ben van Lier
Scoop.it!

China Reports Two Deaths From H7N9 Bird Flu

The first fatalities among China's avian flu cases came after two people in the province of Anhui have died of the bird flu infection. Anhui has s
more...
No comment yet.
Scooped by Ben van Lier
Scoop.it!

East China's Jiangxi reports two more H7N9 cases

Via Xinhua: East China's Jiangxi reports two more H7N9 cases. Two more human infections of H7N9 bird flu were reported in east China's Jiangxi Province, bringing total number of infections to 30 in the province this year. The ne
more...
No comment yet.
Scooped by Ben van Lier
Scoop.it!

WHO urges China to watch for sustained spread of H7N9 among humans

Virus has mainly been passed by birds, but fears grow of more human-to-human transmission
more...
No comment yet.
Scooped by Ben van Lier
Scoop.it!

#China, #Guizhou province reported a #human case of #H7N9 #influenza #infection (Xinhua, Feb. 25 ‘17)

Infectious Diseases and Emerging Threats tracking and monitoring blog
more...
No comment yet.
Scooped by Ben van Lier
Scoop.it!

#China, #Jiangxi province reported two #human cases of #H7N9 #influenza in the last ten days; 30 so far this year (Feb. 25 ‘17)

Infectious Diseases and Emerging Threats tracking and monitoring blog
more...
No comment yet.
Scooped by Ben van Lier
Scoop.it!

WHO H7N9 update

WHO has published Human infection with avian influenza A(H7N9) virus – China. Excerpt: On 4 February 2017, Taipei Centers for Disease Control and Prevention (CDC) reported one laboratory-confirmed case of human infection with avian influenza A(H7N9) virus. This i
more...
No comment yet.
Scooped by Ben van Lier
Scoop.it!

China reports more severe form of H7N9 bird flu

China is working to assess the prevalence of a new strain of H7N9 bird flu, state radio reported, after global health authorities said the strain had evolved into a more severe form i
more...
No comment yet.
Scooped by Ben van Lier
Scoop.it!

H7N9 Mutation Makes Bird Flu Virus Drug-Resistant And More Infectious – Diet Tips Blog

H7N9 Mutation Makes Bird Flu Virus Drug-Resistant And More Infectious https://t.co/ELFXf6b7OD
more...
No comment yet.
Scooped by Ben van Lier
Scoop.it!

China - Government media reports 77 H7N9 avian flu cases and 8 deaths for the first 2 weeks of February 2017 + 4 vaccines approved for clinical tests - FluTrackers News and Information

Xinhua is a government media outlet.
China Focus: China steps up prevention of human H7N9 avian flu
more...
No comment yet.