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H7N9 flu peril lies in deep lung infiltration: study

H7N9 flu peril lies in deep lung infiltration: study | Avian influenza virus A(H7N9) | Scoop.it
Paris (AFP) July 03, 2013 - The H7N9 bird flu virus is a peril for humans because it replicates deep in the lungs where it can trigger a dangerous response from the immune system, a study said Wednesday.

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Rescooped by Ben van Lier from Virology and Bioinformatics from Virology.ca
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Human H7N9 and H5N1 influenza viruses differ in induction of cytokines and tissue tropism

Since emerging in 2013, the avian-origin H7N9 influenza viruses have resulted in over 400 human infections leading to 115 deaths to date. Although the epidemiology differs from human highly pathogenic avian H5N1 influenza infections, there is a similar rapid progression to acute respiratory distress syndrome (ARDS). The aim of these studies was to compare the pathological and immunological characteristics of a panel of human H7N9 and H5N1 viruses in vitro and in vivo. Although there were similarities between particular H5N1 and H7N9 viruses, including association between lethal disease and spread to the alveolar spaces and kidney, there were also strain-specific differences. Both H5N1 and H7N9 viruses are capable of causing lethal infections, with mortality correlating most strongly with wider distribution of viral antigen in the lungs, rather than with traditional measures of viral titer and host responses. Strain-specific differences included hypercytokinemia in H5N1 infections that was not seen with the H7N9 infections regardless of lethality. Conversely, H7N9 viruses showed a greater tropism for respiratory epithelium covering nasal passages and NALT than H5N1 viruses, which may explain the enhanced transmission in ferret models. Overall these studies highlight some distinctive properties of H5N1 and H7N9 viruses in different in vitro and in vivo models.

Importance The novel avian-origin H7N9 pandemic represents a serious threat to public health. The ability of H7N9 to cause serious lung pathology leading in some cases to the development of acute respiratory distress syndrome is of particular concern. Initial reports of H7N9 infection compared them to infections caused by highly pathogenic avian (HPAI) H5N1 viruses. Thus, it is of critical importance to understand the pathology and immunological response to infection with H7N9 as compared to HPAI H5N1 viruses. We compared these responses in both in vitro and in vivo models, and found that H5N1 and H7N9 infections exhibit distinct pathological, immunological and tissue tropism differences that could explain differences in clinical disease and viral transmission.


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China reports two H7N9 avian influenza cases from Xinjiang Uygur | Outbreak News Today

China reports two H7N9 avian influenza cases from Xinjiang Uygur | Outbreak News Today | Avian influenza virus A(H7N9) | Scoop.it
RT @MicrobesInfect: China reports two new #H7N9 avian influenza cases from Xinjiang Uygur autonomous region http://t.co/PeyPzC57WS
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Editorial Commentary: Some Perspectives Regarding Risk Factors for A(H7N9) Influenza Virus Infection in Humans

Editorial Commentary: Some Perspectives Regarding Risk Factors for A(H7N9) Influenza Virus Infection in Humans | Avian influenza virus A(H7N9) | Scoop.it
Editorial Commentary: Some Perspectives Regarding Risk Factors for A(H7N9) Influenza Virus Infection in Humans http://t.co/lk4jsFQOrR
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Additional case of bird flu brings total to 436 this year in China - Vaccine News Daily

Vaccine News Daily
Additional case of bird flu brings total to 436 this year in China
Vaccine News Daily
Avian flu cases have been reported in 18 areas in China.
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WHO | Human infection with avian influenza A(H7N9) virus – update

On 22-23 and 25 April 2014, Taipei Centers for Disease Control (CDC) reported 2 additional laboratory-confirmed cases of human infection with avian influenza A(H7N9).
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An H7N1 influenza virus vaccine induces broadly reactive antibody responses against H7N9 in humans.

Emerging H7N9 influenza virus infections in Asia have once more spurred the development of effective pre-pandemic H7 vaccines. However, many vaccines based on avian influenza viruses - including H7 - are poorly immunogenic as measured by traditional correlates of protection. Here we re-evaluated sera from an H7N1 human vaccine trial performed in 2006. We examined cross-reactive antibody responses to divergent H7 strains including H7N9, dissected the antibody response into head versus stalk reactive antibodies, and tested the in vivo potency of these human sera in a passive transfer H7N9 challenge experiment in mice. Although only a low percentage of vaccinees induced neutralizing antibody responses against the homologous vaccine strain and also H7N9, we detected strong cross-reactivity to divergent H7 HAs in a large proportion of the cohort using a quantitative ELISA method. Furthermore, H7N1 vaccination induced antibodies to both the head and the stalk domain of the HA which is in sharp contrast to seasonal inactivated vaccines. Finally, we were able to show that both, neutralizing but also non-neutralizing antibodies improved in vivo virus clearance in a passive transfer H7N9 challenge mouse model.

 


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Deadly strain of bird flu in China linked to live poultry markets; high ...

Deadly strain of bird flu in China linked to live poultry markets; high ... | Avian influenza virus A(H7N9) | Scoop.it
A new study reveals conditions linked to the emergence and spread of deadly bird flu and maps the areas of Asia at greatest risk of the spread of the new virus strain. A dangerous strain of avian influenza, H7N9, that's causing ...
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Bird Flu Maps | The Scientist Magazine®

Bird Flu Maps | The Scientist Magazine® | Avian influenza virus A(H7N9) | Scoop.it
Researchers map regions in Asia with the highest risk for transmission of H7N9.
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Four Cases of Human Infection with H7N9 Virus are Reported to WHO - Infection Control Today

Four Cases of Human Infection with H7N9 Virus are Reported to WHO - Infection Control Today | Avian influenza virus A(H7N9) | Scoop.it
Four Cases of Human Infection with H7N9 Virus are Reported to WHO Infection Control Today WHO encourages countries to continue strengthening influenza surveillance, including surveillance for severe acute respiratory infections (SARI) and to...
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WHO | Human infection with avian influenza A(H7N9) virus – update

On 12 May 2014, the National Health and Family Planning Commission (NHFPC) of China notified WHO of five additional laboratory-confirmed cases of human infection with avian influenza A(H7N9) virus.
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Five More Cases Of Bird Flu Reported In China - RTT News

Five More Cases Of Bird Flu Reported In China - RTT News | Avian influenza virus A(H7N9) | Scoop.it
Five More Cases Of Bird Flu Reported In China RTT News The United Nations' World Health Organization (WHO) revealed it has been notified by China's National Health and Family Planning Commission of five additional laboratory-confirmed cases of...
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Potential H7N9 bird flu vaccine shows promise | Science News

Potential H7N9 bird flu vaccine shows promise | Science News | Avian influenza virus A(H7N9) | Scoop.it
From the desk of Zedie. (Potential H7N9 bird flu vaccine shows promise | Science News http://t.co/sTEe3Mi5UG)
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Mutant bird flu virus worry Bangladeshi scientists - SciDev.Net South Asia

Mutant bird flu virus worry Bangladeshi scientists - SciDev.Net South Asia | Avian influenza virus A(H7N9) | Scoop.it
As the bird flu virus mutates rapidly in Bangladesh, scientists are calling for stricter monitoring and bio-security drills. (Ew gross! ...
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Woman Dies Of Bird Flu In China - RTT News

Woman Dies Of Bird Flu In China RTT News The United Nations World Health Organization (WHO) said Thursday that China's National Health and Family Planning Commission has notified it of two new laboratory-confirmed case of human infection with avian...
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Seroprevalence to Avian Influenza A(H7N9) Virus Among Poultry Workers and the General Population in Southern China: A Longitudinal Study

Seroprevalence to Avian Influenza A(H7N9) Virus Among Poultry Workers and the General Population in Southern China: A Longitudinal Study | Avian influenza virus A(H7N9) | Scoop.it
Background. Confirmed cases of avian influenza A(H7N9) virus infection in humans continue to occur in mainland... http://t.co/U2gL7BEciX
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New cases of H7N9 (highly pathogenic avian influenza): Taipei ...

New cases of H7N9 (highly pathogenic avian influenza): Taipei ... | Avian influenza virus A(H7N9) | Scoop.it
Biological Hazard – H7N9 (highly pathogenic avian influenza) Asia – Taiwan | Taipei Bio-hazard Level: 4/4 Hazardous Affected unknown Location: N 25° 5.465, E 121° 33.590 Deaths: unknown Infected: 2 Biological Hazard ...
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On the Use of Human Mobility Proxies for Modeling Epidemics

On the Use of Human Mobility Proxies for Modeling Epidemics | Avian influenza virus A(H7N9) | Scoop.it

The spatial dissemination of a directly transmitted infectious disease in a population is driven by population movements from one region to another allowing mixing and importation. Public health policy and planning may thus be more accurate if reliable descriptions of population movements can be considered in the epidemic evaluations. Next to census data, generally available in developed countries, alternative solutions can be found to describe population movements where official data is missing. These include mobility models, such as the radiation model, and the analysis of mobile phone activity records providing individual geo-temporal information. Here we explore to what extent mobility proxies, such as mobile phone data or mobility models, can effectively be used in epidemic models for influenza-like-illnesses and how they compare to official census data. By focusing on three European countries, we find that phone data matches the commuting patterns reported by census well but tends to overestimate the number of commuters, leading to a faster diffusion of simulated epidemics. The order of infection of newly infected locations is however well preserved, whereas the pattern of epidemic invasion is captured with higher accuracy by the radiation model for centrally seeded epidemics and by phone proxy for peripherally seeded epidemics.


Tizzoni M, Bajardi P, Decuyper A, Kon Kam King G, Schneider CM, et al. (2014) On the Use of Human Mobility Proxies for Modeling Epidemics. PLoS Comput Biol 10(7): e1003716. http://dx.doi.org/10.1371/journal.pcbi.1003716


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H7N9 (highly pathogenic avian influenza): Taiwan | Head Space

H7N9 (highly pathogenic avian influenza): Taiwan | Head Space | Avian influenza virus A(H7N9) | Scoop.it
Biological Hazard – H7N9 (highly pathogenic avian influenza) Asia – Taiwan | Taipei Bio-hazard Level: 4/4 Hazardous Affected unknown Location: N 25° 5.465, E 121° 33.590 Deaths: unknown Infected: 2 Biological Hazard ...
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CDC - Top 10 Influenza Pandemic Response Planning Tips for H7N9 Virus | Avian Influenza (Flu)

CDC - Top 10 Influenza Pandemic Response Planning Tips for H7N9 Virus | Avian Influenza (Flu) | Avian influenza virus A(H7N9) | Scoop.it
H7N9 influenza pandemic response planning tips for senior public health officials - CDC (Top 10 #influenza #pandemic response planning tips http://t.co/fQeGFdBd7Y)...
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Predicting the risk of avian influenza A H7N9 infection in live-poultry markets across Asia - FluTrackers

Predicting the risk of avian influenza A H7N9 infection in live-poultry markets across Asia West Bengal (Predicting the risk of avian influenza A H7N9 infection in live-poultry markets across Asia http://t.co/xGZeIpzIQC...
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WHO | Human infection with avian influenza A(H7N9) virus – update

On 26 May 2014, the National Health and Family Planning Commission (NHFPC) of China notified WHO of three additional laboratory confirmed cases of human infection with avian influenza A(H7N9) virus.
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Four More Cases Of Bird Flu Reported In China - RTT News

Four More Cases Of Bird Flu Reported In China - RTT News | Avian influenza virus A(H7N9) | Scoop.it
Four More Cases Of Bird Flu Reported In China RTT News "WHO encourages countries to continue strengthening influenza surveillance, including surveillance for severe acute respiratory infections (SARI) and to carefully review any unusual patterns,...
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WHO | Human infection with avian influenza A(H7N9) virus – update

On 12 May 2014, the National Health and Family Planning Commission (NHFPC) of China notified WHO of five additional laboratory-confirmed cases of human infection with avian influenza A(H7N9) virus.
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A TIME'S MEMORY: Human infection with avian influenza A(H7N9) virus – update (WHO, May 15 2014)

Human infection with avian influenza A(H7N9) virus – update (WHO, May 15 2014) http://t.co/jBWRnEuU2t
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WHO | Human infection with avian influenza A(H7N9) virus – update

On 25 and 28 April 2014, the National Health and Family Planning Commission (NHFPC) of China notified WHO of three additional laboratory-confirmed cases of human infection with avian influenza A(H7N9) virus.
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