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Biological features of novel avian influenza A (H7N9) virus - Nature

Human infection associated with a novel reassortant avian influenza H7N9 virus has recently been identified in China1. A total of 132 confirmed cases and 39 deaths have been reported2. Most patients presented with severe pneumonia and acute respiratory distress syndrome3, 4. Although the first epidemic has subsided, the presence of a natural reservoir and the disease severity highlight the need to evaluate its risk on human public health and to understand the possible pathogenesis mechanism. Here we show that the emerging H7N9 avian influenza virus poses a potentially high risk to humans. We discover that the H7N9 virus can bind to both avian-type (α2,3-linked sialic acid) and human-type (α2,6-linked sialic acid) receptors. It can invade epithelial cells in the human lower respiratory tract and type II pneumonocytes in alveoli, and replicated efficiently in ex vivo lung and trachea explant culture and several mammalian cell lines. In acute serum samples of H7N9-infected patients, increased levels of the chemokines and cytokines IP-10, MIG, MIP-1β, MCP-1, IL-6, IL-8 and IFN-α were detected. We note that the human population is naive to the H7N9 virus, and current seasonal vaccination could not provide protection


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Flu genomes trace H7N9's evolution and spread in China - Nature.com

Flu genomes trace H7N9's evolution and spread in China - Nature.com | Avian influenza virus A(H7N9) | Scoop.it
But surveillance of avian influenza viruses is patchy and slow.
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H7N9 Bird Flu Is Mutating, Sparks Pandemic Concerns

H7N9 Bird Flu Is Mutating, Sparks Pandemic Concerns | Avian influenza virus A(H7N9) | Scoop.it
The H7N9 bird flu strain is mutating and is now reportedly being spread from chicken flocks to duck flocks. Agriculture researchers reportedly feel that the
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Mutated bird flu leads to new pandemic fears

A new strain of H7N9 – commonly known as bird flu – has infected over 500 people since the beginning of 2013, mostly throughout Asia and Canada. Scientists and doctors are worried about...
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In the Wake of Ebola—H7N9 Influenza Has Spread in Secret - Science Times

In the Wake of Ebola—H7N9 Influenza Has Spread in Secret - Science Times | Avian influenza virus A(H7N9) | Scoop.it
In the wake of the Ebola pandemic, researchers in China have identified a virus capable of global infection that has been mutating and brewing on the sidelines. A strain of the avian influenza, the H7N9 flu emerged in eastern China in Feb.
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H7N9 Bird Flu Has the Makings of a Pandemic Virus - Sci-Tech Today

H7N9 Bird Flu Has the Makings of a Pandemic Virus - Sci-Tech Today | Avian influenza virus A(H7N9) | Scoop.it
Scientists in China have identified an influenza virus that they say has the potential to spread around the world, sickening and killing people whose immune systems have never faced a threat like it.
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Human infection with avian influenza A(H7N9) virus – China - World Health Organization (press release)

On 9 March 2015, the National Health and Family Planning Commission (NHFPC) of China notified WHO of 59 additional laboratory-confirmed cases of human infection with avian influenza A(H7N9) virus, including 17 fatal cases.
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Dissemination, divergence and establishment of H7N9 influenza viruses in China

Dissemination, divergence and establishment of H7N9 influenza viruses in China | Avian influenza virus A(H7N9) | Scoop.it
Since 2013 the occurrence of human infections by a novel avian H7N9 influenza virus in China has demonstrated the continuing threat posed by zoonotic pathogens.
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Scientists Warn H7N9 Bird Flu Could Be Next Pandemic | EMSWorld.com

Scientists Warn H7N9 Bird Flu Could Be Next Pandemic | EMSWorld.com | Avian influenza virus A(H7N9) | Scoop.it
H7N9 flu emerged in humans in eastern China in February 2013 before winding down in May; it reemerged in October 2013 and has been spreading steadily since
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Threatwatch: Bird flu's back and it's brought friends - health - 11 March 2015 - New Scientist

Threatwatch: Bird flu's back and it's brought friends - health - 11 March 2015 - New Scientist | Avian influenza virus A(H7N9) | Scoop.it
Bird flu is breaking out in Egypt and invading the US, while a new strain in China is poised to spread across the world
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Bird flu mutating in southern China, pandemic threatens: Shanghaiist

Bird flu mutating in southern China, pandemic threatens: Shanghaiist | Avian influenza virus A(H7N9) | Scoop.it
Bird flu mutating in southern China, pandemic threatens: Shanghaiist

The deadly strain of the bird flu virus H7N9, which first infected humans in Shanghai during 2013, is entrenched in flocks of...
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Chickens to blame for spread of latest deadly bird flu

Chickens to blame for spread of latest deadly bird flu | Avian influenza virus A(H7N9) | Scoop.it
Chickens are responsible for the second wave of H7N9 bird flu in China.
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Bird flu hits U.S. turkeys, H7N9 spreads in China

Bird flu hits U.S. turkeys, H7N9 spreads in China | Avian influenza virus A(H7N9) | Scoop.it
The feds have confirmed an outbreak of a highly contagious bird flu in a commercial turkey flock in Arkansas.
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China reports 19 additional human H7N9 bird flu cases | Outbreak News Today

China reports 19 additional human H7N9 bird flu cases | Outbreak News Today | Avian influenza virus A(H7N9) | Scoop.it
#news #flu China reports 19 additional human H7N9 bird flu cases - Outbreak News Today http://t.co/7N3LpGOjOE
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Shanghai reports another H7N9 human infection - Xinhua | English.news.cn

Shanghai reports another H7N9 human infection - Xinhua | English.news.cn | Avian influenza virus A(H7N9) | Scoop.it
SHANGHAI,April 4(Xinhua)--China's financial hub Shanghai reported another human infection of the H7N9 strain of bird flu,local health official said on Saturday y.
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Bird flu spreads within U.S. and China

Bird flu spreads within U.S. and China | Avian influenza virus A(H7N9) | Scoop.it
An update on avian flu: China has reported new H7N9 bird flu infections in humans and across the globe, other strains have been detected in U.S. commercial turkey farms.
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Finches can pass H7N9 bird flu to chickens

Finches can pass H7N9 bird flu to chickens | Avian influenza virus A(H7N9) | Scoop.it
In laboratory experiments, society finches spread H7N9 into water when they drank, infecting chickens and quail that drank the same water.
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Bird flu mutating in southern China, pandemic threatens

Bird flu mutating in southern China, pandemic threatens | Avian influenza virus A(H7N9) | Scoop.it
Image credit: @doug88. The deadly strain of the bird flu virus
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Flu genomes trace H7N9's evolution and spread in China

Flu genomes trace H7N9's evolution and spread in China | Avian influenza virus A(H7N9) | Scoop.it
But surveillance of avian influenza viruses is patchy and slow.
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H7N9 bird flu has the makings of a pandemic virus, scientists warn

H7N9 bird flu has the makings of a pandemic virus, scientists warn | Avian influenza virus A(H7N9) | Scoop.it
Scientists in China have identified an influenza virus that they say has the potential to spread around the world, sickening and killing people whose immune systems have never faced a threat like it.
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Bird Flu Mutating in China, Threatens Pandemic

Bird Flu Mutating in China, Threatens Pandemic | Avian influenza virus A(H7N9) | Scoop.it
The H7N9 bird flu virus is being passed around from flock to flock of chickens and ducks, is mutating, and is now a bigger threat than ever to humanity, rese...
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Bird flu mutating in southern China, pandemic threatens: Shanghaiist

Bird flu mutating in southern China, pandemic threatens: Shanghaiist | Avian influenza virus A(H7N9) | Scoop.it
The deadly strain of the bird flu virus H7N9, which first infected humans in Shanghai during 2013, is entrenched in flocks of chickens and ducks in the south of China and mutating, posing an even g...
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Flu Virus in China Has Pandemic Potential, Scientists Say

Flu Virus in China Has Pandemic Potential, Scientists Say | Avian influenza virus A(H7N9) | Scoop.it
A dangerous influenza virus spreading in China's live poultry markets has the potential to become a worldwide pandemic, researchers say. They are calling for these markets to be permanently close...
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Mutating H7N9 bird flu may pose pandemic threat, scientists warn

Mutating H7N9 bird flu may pose pandemic threat, scientists warn | Avian influenza virus A(H7N9) | Scoop.it
The H7N9 virus, one of several strains of bird flu known to be able to infect humans, has persisted, diversified and spread
in chickens across China, researchers said.
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Current bird flu in China could become ‘pandemic’ threat to humans, researchers say

Current bird flu in China could become ‘pandemic’ threat to humans, researchers say | Avian influenza virus A(H7N9) | Scoop.it
The virus has sickened 318 people and killed more than 100 in China

Via Dr. Stefan Gruenwald
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