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First "mini human brains" grown from stem cells

First "mini human brains" grown from stem cells | Ingeniería Biomédica | Scoop.it

Scientists have grown the first mini human brains in a laboratory and say their success could lead to new levels of understanding about the way brains develop and what goes wrong in disorders like schizophrenia and autism.

 

Researchers based in Austria started with human stem cells and created a culture in the lab that allowed them to grow into so-called "cerebral organoids" - or mini brains - that consisted of several distinct brain regions. It is the first time that scientists have managed to replicate the development of brain tissue in three dimensions.

 

Using the organoids, the scientists were then able to produce a biological model of how a rare brain condition called microcephaly develops - suggesting the same technique could in future be used to model disorders like autism or schizophrenia that affect millions of people around the world.

 

"This study offers the promise of a major new tool for understanding the causes of major developmental disorders of the brain ... as well as testing possible treatments," said Paul Matthews, a professor of clinical neuroscience at Imperial College London, who was not involved in the research but was impressed with its results.

 

Zameel Cader, a consultant neurologist at Britain's John Radcliffe Hospital in Oxford, described the work as "fascinating and exciting". He said it extended the possibility of stem cell technologies for understanding brain development and disease mechanisms - and for discovering new drugs.

 

Although it starts as relatively simple tissue, the human brain swiftly develops into the most complex known natural structure, and scientists are largely in the dark about how that happens. This makes it extremely difficult for researchers to gain an understanding of what might be going wrong in - and therefore how to treat - many common disorders of the brain such as depression, schizophrenia and autism.

 

To create their brain tissue, Juergen Knoblich and Madeline Lancaster at Austria's Institute of Molecular Biotechnology and fellow researchers at Britain's Edinburgh University Human Genetics Unit began with human stem cells and grew them with a special combination of nutrients designed to capitalize on the cells' innate ability to organize into complex organ structures. They grew tissue called neuroectoderm - the layer of cells in the embryo from which all components of the brain and nervous system develop.

 

Fragments of this tissue were then embedded in a scaffold and put into a spinning bioreactor - a system that circulates oxygen and nutrients to allow them to grow into cerebral organoids.

 

After a month, the fragments had organized themselves into primitive structures that could be recognized as developing brain regions such as retina, choroid plexus and cerebral cortex, the researchers explained in a telephone briefing.

 

At two months, the organoids reached a maximum size of around 4 millimeters (0.16 inches), they said. Although they were very small and still a long way from resembling anything like the detailed structure of a fully developed human brain, they did contain firing neurons and distinct types of neural tissue.

 


Via Dr. Stefan Gruenwald
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Scooped by Alexis Meneses Arévalo
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New Ultrafast, Long-Lasting Aluminum Battery - IEEE Spectrum

Low cost, long cycle life and flexibility makes new system promising for grid storage and wearables
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El secreto del magnate brasileño dueño de Heinz, Kraft Foods y Burger King

El secreto del magnate brasileño dueño de Heinz, Kraft Foods y Burger King | Ingeniería Biomédica | Scoop.it
Jorge Paulo Lemann busca a trabajadores "pobres, inteligentes y con unas ganas profundas de hacerse ricos". Es una persona discreta obsesionada con la reducción de costos empresariales.
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Fabricar plástico con restos de pan | Todos los contenidos | DW.DE | 05.04.2015

Fabricar plástico con restos de pan | Todos los contenidos | DW.DE | 05.04.2015 | Ingeniería Biomédica | Scoop.it
En muchas panaderías alemanas, a la hora del cierre, sobran grandes cantidades de pan, imposibles de vender al día siguiente.
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Frustrated magnets -- new experiment reveals clues to their discontent

Frustrated magnets -- new experiment reveals clues to their discontent | Ingeniería Biomédica | Scoop.it
An experiment conducted by Princeton researchers has revealed an unlikely behavior in a class of materials called frustrated magnets, addressing a long-debated question about the nature of these discontented quantum materials. The work represents a surprising ...
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Chip Could Double Wireless Data Capacity - IEEE Spectrum

Chip Could Double Wireless Data Capacity - IEEE Spectrum | Ingeniería Biomédica | Scoop.it
IC that transmits and receives on the same frequency could free up bandwidth in Wi-Fi and cellular networks
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Lo que quizás no sabías de la electricidad

Lo que quizás no sabías de la electricidad | Ingeniería Biomédica | Scoop.it
...y de las sillas eléctricas. ¿Qué pasó después de que Dios dijo “Hágase la luz”? Datos e historias curiosas recopiladas por el equipo de QI para la BBC en esta serie que esperamos te lleve a pensar: ¡Qué interesante!
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El remedio medieval que "destruye" superbacterias

El remedio medieval que "destruye" superbacterias | Ingeniería Biomédica | Scoop.it
Un remedio anglosajón recreado por científicos británicos, mostró un poder "sorprendente" contra el estafilococo dorado resistente a la meticilina. Te contamos en qué consiste.
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Video Friday: Chameleon Gripper, Swarmie Robots, and Superman With GoPro - IEEE Spectrum

Video Friday: Chameleon Gripper, Swarmie Robots, and Superman With GoPro - IEEE Spectrum | Ingeniería Biomédica | Scoop.it
If sticky tongues aren't your thing, we've got lots more robot videos for you
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Wearable Electronic Devices Monitor Vital Signs, Activity Level, and More

Wearable Electronic Devices Monitor Vital Signs, Activity Level, and More | Ingeniería Biomédica | Scoop.it
The devices, loaded with sensors or connected to bodily worn sensors, monitor day-to-day activity and personal health. An increasing awareness of our health has fueled interest in measuring vital parameters—such as heart rate, temperature, oxygen saturation, blood pressure, activity level, and calories burned—and following their daily trends.
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Three Technologies for Harvesting Ambient Energy - IEEE Spectrum

Three Technologies for Harvesting Ambient Energy - IEEE Spectrum | Ingeniería Biomédica | Scoop.it
Consumer devices will run longer by pulling power from the environment
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Mobile System Captures High-Resolution Images Inside the Eye

Mobile System Captures High-Resolution Images Inside the Eye | Ingeniería Biomédica | Scoop.it
A smart and simple method developed at Rice University to image a patient’s eye could help monitor eye health and spot signs of macular degeneration and diabetic retinopathy, especially in developing nations. The patient-operated, portable...
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13 optical illusions more mind-boggling than the dress - StumbleUpon

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Tecnología espacial para reducir la ceguera por degeneración macular / Noticias / SINC

Tecnología espacial para reducir la ceguera por degeneración macular / Noticias / SINC | Ingeniería Biomédica | Scoop.it
SINC, Servicio de Información y Noticias Científicas, plataforma multimedia de comunicación científica
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El ordenador más pequeño del mundo tiene solo dos milímetros de diámetro

El ordenador más pequeño del mundo tiene solo dos milímetros de diámetro | Ingeniería Biomédica | Scoop.it
Científicos de la Universidad de Michigan (EE.UU.) han creado el ordenador más pequeño del mundo, con dos milímetros de diámetro, el Michigan Micro Mote (M3). Consta de un miniprocesador, y de una célula solar de 1 milimetro cuadrado que alimenta su pequeña batería.
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Aprenden más rápido aquellos que “desconectan” ciertas áreas cerebrales

Aprenden más rápido aquellos que “desconectan” ciertas áreas cerebrales | Ingeniería Biomédica | Scoop.it
¿Por qué algunas personas son capaces de dominar una nueva habilidad rápidamente, mientras otras requieren de más tiempo? Científicos estadounidenses han descubierto una de las claves de esta diferencia. Según su estudio, aprenden más rápidamente aquellos capaces de “desconectar” las área...
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A new breakthrough in thermoelectric materials

A new breakthrough in thermoelectric materials | Ingeniería Biomédica | Scoop.it
French physicist Jean Charles Athanase Peltier discovered a key concept necessary for thermoelectric (TE) temperature control in 1834. His findings were so significant, TE devices are now commonly referred to Peltier devices. Since his work ...
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Special Report: 50 Years of Moore's Law - IEEE Spectrum

The glorious history and inevitable decline of one of technology’s greatest winning streaks
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This mechanical exoskeleton makes walking more efficient

For the first time, researchers can improve the way humans walk without using an external power source, according to a study published in Nature today. A boot-like exoskeleton that fits into a...
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La sorprendente capacidad de las hormigas ante la falta de gravedad

La sorprendente capacidad de las hormigas ante la falta de gravedad | Ingeniería Biomédica | Scoop.it
Ocho colonias de hormigas fueron enviadas a la Estación Espacial Internacional para investigar su comportamiento social en dicho ambiente. Los científicos se llevaron una buena sorpresa.
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Nuestro cerebro reconoce las palabras igual que las caras: de una sola vez

Nuestro cerebro reconoce las palabras igual que las caras: de una sola vez | Ingeniería Biomédica | Scoop.it
Cuando nos fijamos en una palabra conocida, nuestro cerebro la ve como una imagen completa, no como a un mero grupo de letras que hay que descifrar, revela un estudio. El aprendizaje de las palabras se produce de la misma forma, aunque estas sean irreales, señala esa misma investigación.
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Graphene Supercharges 3-D Hybrid Supercapacitor - IEEE Spectrum

Graphene Supercharges 3-D Hybrid Supercapacitor - IEEE Spectrum | Ingeniería Biomédica | Scoop.it
New supercapacitor combines graphene with traditional battery material
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Lista de aplicaciones web multimedia en la nube

Lista de aplicaciones web multimedia en la nube | Ingeniería Biomédica | Scoop.it
Las aplicaciones web en la nube te permiten abrir cualquier navegador y entrar en una página web para usar una aplicación online, que no necesitas tener
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A Brain-Computer Interface That Lasts for Weeks - IEEE Spectrum

A Brain-Computer Interface That Lasts for Weeks - IEEE Spectrum | Ingeniería Biomédica | Scoop.it
Flexible EEG sensor stays stuck to your through showers, swims, and sleep
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How long will it take for my 510(k) to be cleared by the FDA?

See how many calendar days it has historically taken for the US Food and Drug Administration to clear other medical devices with the same Product Code.
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