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Type 1 diabetes—progress and prospects : The Lancet

Type 1 diabetes—progress and prospects. By - The Lancet

Via Ellen H Ullman, MSW
Gilbert C FAURE's insight:

link with a report on paediatric diabetes in UK

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AUTOIMMUNITY
Pathology, Diagnosis and Therapies
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Autoimmunity

Pathology, Diagnosis and Therapy

Gilbert C FAURE's insight:

Autoimmunity is indeed one of the biggest challenge of Immunology!

Understanding the mechanisms of this physiological immune phenomenon inducing such a diverse array of diseases, joint and muscular, digestive, endocrinological, neurological, cutaneous..

 

Improving the molecular and cellular tools in use for a few decades for diagnosis and follow-up of patients, perhaps screening in the future

Mastering the molecular and cellular therapies to treat patients.

 

You can also find relevant informations on some other topics curated  here such as

Rheumatology http://www.scoop.it/t/rheumatology-rhumatologie

Immunology and biotherapies http://www.scoop.it/t/immunology-and-biotherapies

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UF Health diabetes researchers discover way to expand potent regulatory cells

For parents, storing their newborn baby's umbilical cord blood is a way to preserve potentially lifesaving cells. Now, a group of University of Florida Health researchers has found a way to expand and preserve certain cord-blood cells as a potential treatment for type 1 diabetes.
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Detection in blood of autoantibodies to tumour antigens as a case-finding method in lung cancer using the EarlyCDT®-Lung Test (ECLS): study protocol for a randomized controlled trial

Detection in blood of autoantibodies to tumour antigens as a case-finding method in lung cancer using the EarlyCDT®-Lung Test (ECLS): study protocol for a randomized controlled trial | AUTOIMMUNITY | Scoop.it
Lung cancer is the most common cause of cancer related death worldwide. The majority of cases are detected at a late stage when prognosis is poor. The EarlyCDT®-Lung Test detects autoantibodies to abnormal cell surface proteins in the earliest stages of the disease which may allow tumour detection at an earlier stage thus altering prognosis. The primary research question is: Does using the EarlyCDT®-Lung Test to identify those at high risk of lung cancer, followed by X-ray and computed tomography (CT) scanning, reduce the incidence of patients with late-stage lung cancer (III & IV) or unclassified presentation (U) at diagnosis, compared to standard practice? A randomised controlled trial of 12 000 participants in areas of Scotland targeting general practices serving patients in the most deprived quintile of the Scottish Index of Multiple Deprivation. Adults aged 50–75 who are at high risk of lung cancer and healthy enough to undergo potentially curative therapy (Performance Status 0–2) are eligible to participate. The intervention is the EarlyCDT®-Lung Test, followed by X-ray and CT in those with a positive result. The comparator is standard clinical practice in the UK. The primary outcome is the difference, after 24 months, between the rates of patients with stage III, IV or unclassified lung cancer at diagnosis. The secondary outcomes include: all-cause mortality; disease specific mortality; a range of morbidity outcomes; cost-effectiveness and measures examining the psychological and behavioural consequences of screening. Participants with a positive test result but for whom the CT scan does not lead to a lung cancer diagnosis will be offered 6 monthly thoracic CTs for 24 months. An initial chest X-ray will be used to determine the speed and the need for contrast in the first screening CT. Participants who are found to have lung cancer will be followed-up to assess both time to diagnosis and stage of disease at diagnosis. The study will determine the clinical and cost effectiveness of EarlyCDT®-Lung Test for early lung cancer detection and assess its suitability for a large-scale, accredited screening service. The study will also assess the potential psychological and behavioural harms arising from false positive or false negative results, as well as the potential benefits to patients of true negative EarlyCDT lung test results. A cost-effectiveness model of lung cancer screening based on the results of the EarlyCDT Lung Test study will be developed.

NCT01925625

. August 19, 2013
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Autoimmune encephalitis in children: clinical phenomenology, therapeutics, and emerging challenges. - PubMed - NCBI

Autoimmune encephalitis in children: clinical phenomenology, therapeutics, and emerging challenges. - PubMed - NCBI | AUTOIMMUNITY | Scoop.it
Curr Opin Neurol. 2017 Feb 22. doi: 10.1097/WCO.0000000000000443. [Epub ahead of print]
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The Lower Limit of Regulatory CD4+ Foxp3+ TCRβ Repertoire Diversity Required To Control Autoimmunity

The Lower Limit of Regulatory CD4+ Foxp3+ TCRβ Repertoire Diversity Required To Control Autoimmunity | AUTOIMMUNITY | Scoop.it
The TCR repertoire of regulatory T cells (Tregs) is highly diverse. The relevance of this diversity to maintain self-tolerance remains unknown. We established a model where the TCR repertoire of normal polyclonal Tregs was limited by serial transfers into IL-2Rβ−/− mice, which lack functional Tregs. After a primary transfer, the donor Treg TCR repertoire was substantially narrowed, yet the recipients remained autoimmune-free. Importantly, upon purification and transfer of donor-derived Tregs from an individual primary recipient into neonatal IL-2Rβ−/− mice, the secondary recipients developed autoimmunity. In this study, the Treg TCRβ repertoire was reshaped and further narrowed. In contrast, secondary IL-2Rβ recipients showed fewer symptoms of autoimmunity when they received donor Tregs that were premixed from several primary recipients to increase their TCRβ repertoire diversity. About 8–11% of the Treg TCRβ repertoire was estimated to be the minimum required to establish and maintain tolerance in primary IL-2Rβ−/− recipients. Collectively, these data quantify where limitations imposed on the Treg TCRβ repertoire results in a population of Tregs that cannot fully suppress polyclonal autoreactive T cells. Our data favor a model where the high diversity of the Treg TCR provides a mechanism for Tregs to actively adapt and effectively suppress autoreactive T cells, which are not fixed, but are evolving as they encounter self-antigens.
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The immunofluorescence techniques in the diagnosis of endocrine autoimmune diseases

The immunofluorescence techniques in the diagnosis of endocrine autoimmune diseases | AUTOIMMUNITY | Scoop.it
In the study of autoimmune diseases, the laboratory plays a very important role. We describe the immunofluorescence techniques (direct, indirect, complement-fixing, double) for determining the presence of autoantibodies and their role in the autoimmun
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High Density Peptide Microarrays - A Versatile Platform for Autoimmune Research

Peptide microarrays offer a wide range of applications, including linear and conformational epitope mapping, peptide substitution scans, autoantibod
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Abzena and UCL win £3.5m from MRC for autoimmune therapy research - Business Weekly

Abzena and UCL win £3.5m from MRC for autoimmune therapy research - Business Weekly | AUTOIMMUNITY | Scoop.it

"Cambridge life sciences group Abzena and University College London are collaborating to develop a novel autoimmune therapy to tackle a major disorder of the immune system."


Via MRC press office
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MRC press office's curator insight, March 1, 7:32 AM
As part of the initiative, UCL’s Centre for Rheumatology has been awarded a £3.5 million grant from the MRC.
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F1000Research Article: Tertiary lymphoid organs in systemic autoimmune diseases: pathogenic or protective?.

Tertiary lymphoid organs are found at sites of chronic inflammation in autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis. These organized accumulations of T and B cells resemble secondary lymphoid organs and generate autoreactive effector cells. However, whether they contribute to disease pathogenesis or have protective functions is unclear. Here, we discuss how tertiary lymphoid organs can generate potentially pathogenic cells but may also limit the extent of the response and damage in autoimmune disease.
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Role of Cytokine Interleukin-10 in Suppressing Antibody Production in Certain Autoimmune Disorders Focus of NIH Grant Research

Role of Cytokine Interleukin-10 in Suppressing Antibody Production in Certain Autoimmune Disorders Focus of NIH Grant Research | AUTOIMMUNITY | Scoop.it
Study to look at role of the cytokine interleukin-10 (IL-10) in suppressing antibody production in certain autoimmune disorders.
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Autoimmunity against a defective ribosomal insulin gene product in type 1 diabetes

Nature Medicine | doi:10.1038/nm.4289
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The NLRP3 inflammasome in kidney disease and autoimmunity. - PubMed - NCBI

The NLRP3 inflammasome in kidney disease and autoimmunity. - PubMed - NCBI | AUTOIMMUNITY | Scoop.it
Nephrology (Carlton). 2016 Sep;21(9):736-44. doi: 10.1111/nep.12785. Review
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Prevalence and Significance of Autoantibodies in Children Wi... : Journal of Pediatric Gastroenterology and Nutrition

Prevalence and Significance of Autoantibodies in Children Wi... : Journal of Pediatric Gastroenterology and Nutrition | AUTOIMMUNITY | Scoop.it
Objectives: The purpose of the present study is to estimate autoantibody (auto-AB) frequency, clinic
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Methodological Challenges in Protein Microarray and Immunohistochemistry for the Discovery of Novel Autoantibodies in Paediatric Acute Disseminated Encephalomyelitis

Methodological Challenges in Protein Microarray and Immunohistochemistry for the Discovery of Novel Autoantibodies in Paediatric Acute Disseminated Encephalomyelitis | AUTOIMMUNITY | Scoop.it
Acute disseminated encephalomyelitis (ADEM) is a rare autoimmune-mediated demyelinating disease affecting mainly children and young adults. Differentiation to multiple sclerosis is not always possible, due to overlapping clinical symptoms and recurrent and multiphasic forms. Until now, immunoglobulins reactive to myelin oligodendrocyte glycoprotein (MOG antibodies) have been found in a subset of patients with ADEM. However, there are still patients lacking autoantibodies, necessitating the identification of new autoantibodies as biomarkers in those patients. Therefore, we aimed to identify novel autoantibody targets in ADEM patients. Sixteen ADEM patients (11 seronegative, 5 seropositive for MOG antibodies) were analysed for potential new biomarkers, using a protein microarray and immunohistochemistry on rat brain tissue to identify antibodies against intracellular and surface neuronal and glial antigens. Nine candidate antigens were identified in the protein microarray analysis in at least two patients per group. Immunohistochemistry on rat brain tissue did not reveal new target antigens. Although no new autoantibody targets could be found here, future studies should aim to identify new biomarkers for therapeutic and prognostic purposes. The microarray analysis and immunohistochemistry methods used here have several limitations, which should be considered in future searches for biomarkers.
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Alopecia areata

Alopecia areata | AUTOIMMUNITY | Scoop.it
Alopecia areata is an autoimmune disorder characterized by transient hair loss. Severity can range from distinct patches to total hair loss.
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Elevated serum autoantibodies against co-inhibitory PD-1 facilitate T cell proliferation and correlate with disease activity in new-onset systemic lupus erythematosus patients

Elevated serum autoantibodies against co-inhibitory PD-1 facilitate T cell proliferation and correlate with disease activity in new-onset systemic lupus erythematosus patients | AUTOIMMUNITY | Scoop.it
Internal Medicine Article: Elevated serum autoantibodies against co-inhibitory PD-1 facilitate T cell proliferation and correlate with disease activity in new-onset systemic lupus erythematosus patients
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Suppression of lethal autoimmunity by regulatory T cells with a single TCR specificity

Suppression of lethal autoimmunity by regulatory T cells with a single TCR specificity | AUTOIMMUNITY | Scoop.it
The regulatory T cell (T reg cell) T cell receptor (TCR) repertoire is highly diverse and skewed toward recognition of self-antigens. TCR expression by T reg cells is continuously required for maintenance of immune tolerance and for a major part of their characteristic gene expression signature; however, it remains unknown to what degree diverse TCR-mediated interactions with cognate self-antigens are required for these processes. In this study, by experimentally switching the T reg cell TCR repertoire to a single T reg cell TCR, we demonstrate that T reg cell function and gene expression can be partially uncoupled from TCR diversity. An induced switch of the T reg cell TCR repertoire to a random repertoire also preserved, albeit to a limited degree, the ability to suppress lymphadenopathy and T helper cell type 2 activation. At the same time, these perturbations of the T reg cell TCR repertoire led to marked immune cell activation, tissue inflammation, and an ultimately severe autoimmunity, indicating the importance of diversity and specificity for optimal T reg cell function.
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Myocardial Recovery in Patients With Systolic Heart Failure and Autoantibodies Against Beta-1 Adrenergic Receptors

Myocardial Recovery in Patients With Systolic Heart Failure and Autoantibodies Against Beta-1 Adrenergic Receptors | AUTOIMMUNITY | Scoop.it
Myocardial Recovery in Patients With Systolic Heart Failure and Autoantibodies Against Beta-1 Adrenergic Receptors
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Anti-PD-L1 atezolimumab-Induced Autoimmune Diabetes: a Case Report and Review of the Literature

Anti-PD-L1 atezolimumab-Induced Autoimmune Diabetes: a Case Report and Review of the Literature | AUTOIMMUNITY | Scoop.it
Programmed cell death-1 and programmed death ligand 1 (PD-1/PD-L1) inhibitors trigger an immune-mediated anti-tumour response by promoting the activation of cytotoxic T lymphocytes. Although proven to
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Use of self-collected capillary blood samples for islet autoantibody screening in relatives: A feasibility and acceptability study

Diabetic Medicine
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Autoimmune Blistering Diseases - NORD (National Organization for Rare Disorders)

Autoimmune Blistering Diseases - NORD (National Organization for Rare Disorders) | AUTOIMMUNITY | Scoop.it
RT @RareDiseases: Today's #rarediseaseoftheday was Autoimmune Blistering Diseases. Learn more: https://t.co/L3MGoRz3aj
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Autoantibodies may serve as glaucoma biomarkers

Autoantibodies may serve as glaucoma biomarkers | AUTOIMMUNITY | Scoop.it
The loss of autoantibodies may serve as useful biomarkers for glaucoma, according to Nadine von Thun Und Hohenstein-Blaul, Johannes Gutenberg University Mainz, Mainz, Germany, and colleagues.
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Enhanced Bruton's tyrosine kinase activity in peripheral blood B lymphocytes of autoimmune disease patients. - PubMed - NCBI

Enhanced Bruton's tyrosine kinase activity in peripheral blood B lymphocytes of autoimmune disease patients. - PubMed - NCBI | AUTOIMMUNITY | Scoop.it
Arthritis Rheumatol. 2017 Jan 31. doi: 10.1002/art.40059. [Epub ahead of print]
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The Vitiligo Working Group recommendations for narrowband ultraviolet B light phototherapy treatment of vitiligo

Internal Medicine Article: The Vitiligo Working Group recommendations for narrowband ultraviolet B light phototherapy treatment of vitiligo
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Detecting synaptic autoantibodies in psychoses: need for more sensitive methods. - PubMed - NCBI

Detecting synaptic autoantibodies in psychoses: need for more sensitive methods. - PubMed - NCBI | AUTOIMMUNITY | Scoop.it
Curr Opin Neurol. 2017 Feb 22. doi: 10.1097/WCO.0000000000000447. [Epub ahead of print]
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