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Inhibiting NLK in cancers with mutated PTEN could turn the cancer's strength against it

Inhibiting NLK in cancers with mutated PTEN could turn the cancer's strength against it | Art & Science | Scoop.it

A mutation that allows cells to grow out of control could also provide a new way to target and destroy cancer cells. This potential Achilles’ heel comes from a mutation in a gene called PTEN, which is found in a wide range of cancers.

 

PTEN is one of many tumor suppressor genes that we have to prevent our cells from growing out of control. If the PTEN gene stops working because of a mutation, it can cause tumours to develop – indeed many tumors have a mutated form of PTEN. However when a door closes, a window opens: the PTEN mutation helps the tumor to grow, but it could also mark it out as a target.

 

Researchers from the Institute of Cancer Research, London, found that switching off another gene known as NLK (Nemo-like kinase) killed tumor cells that had the PTEN mutation. This makes NLK a good target for drug developers to create a new cancer treatment.

 

Initially, the researchers took samples of tumor cells with and without the mutation, and switched off genes for important proteins that are used for regulating lots of processes in the cell. To do this they used small interfering RNA (or siRNA) which interfere with the processes of specific genes. These siRNAs block the chain of events that allow a gene to produce a protein, effectively switching it off. By switching off 779 genes individually, they could look for ones where cells with the PTEN mutation died and cells without the mutation survived.

 

This is how the researchers discovered the powerful effect of switching off the NLK gene. They are not certain how this works but it appears to protect a protein called FOXO1 that can act as a backup tumor suppressor and cause the cancer cell to die. When PTEN is mutated, the FOXO1 protein becomes vulnerable to a process called phosphorylation, which means it is ejected from the cell nucleus and destroyed. NLK is one of the proteins that phosphorylates FOXO1 and so by switching off the NLK gene, FOXO1 is able to do its job.

 


Via Dr. Stefan Gruenwald
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List of science museums - Wikipedia, the free encyclopedia

Below is the list of science museums all over the world. See Science museum for definitions.

(listed by province)

For all categorized science museums in Canada, see: Science museums in Canada

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complex systems - Audra Wolowiec #artandphysics residency at Uni of Oregon

complex systems - Audra Wolowiec #artandphysics residency at Uni of Oregon | Art & Science | Scoop.it
Complex Systems Art and Physics Residency at the Corwin Lab University of Oregon
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Yeastograms workshop 9-11.12.2013

Yeastograms workshop 9-11.12.2013 | Art & Science | Scoop.it

Pixelache/ Finnish Society of Bioart workshop

 

A bioart workshop with Lucas Czjzek from the Bioart Club pavillon_35 (Vienna, Austria).

 

Yeastograms are alive images out of yeast cells and produced in a photography like process. The yeastogram method has been developed by artists and scientists of pavillon_35. Lucas Czjzek, one of the developers, used this method for his work ANIMA . During the 3 days workshop Lucas Czjzek from the bioart club pavillon_35 is showing a method to cultivate baker’s yeast and how to shape the cultivation according to aesthetic and artistic decisions. The workshop explores the utilization of living organisms in artistic formation and expression using amateur-biological techniques. 

 

 

- See more at: http://www.pixelache.ac/blog/2013/yeastograms-workshop-9-11-12-2013/#sthash.qMNfh9Iz.dpuf

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Central Booking » Haber Space, gallery for art and science exhibitions - Un/Natural Occurrences

Central Booking » Haber Space, gallery for art and science exhibitions - Un/Natural Occurrences | Art & Science | Scoop.it

Un/Natural Occurrences
September 8 – October 27, 2013

The newly named Haber Space, our gallery for art and science exhibitions, will open withUn/Natural Occurrences, also curated by CENTRAL BOOKING’s founder, Maddy Rosenberg, and featuring the work of 25 artists and collaborators. These are artists who are searching for more than the obvious in either bringing to light past and current indiscretions, warning against a catastrophic future if unheeded, working with the scientific community on possible solutions and sometimes just telling it like it is. We view this exhibition as a bookend to Natural Histories, which launched CENTRAL BOOKING’s initial space in 2009.

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Pasadena Arts Council | Pasadena, City of Art and Science

Pasadena Arts Council | Pasadena, City of Art and Science | Art & Science | Scoop.it

Pasadena, City of Art and Science

By Stephen Nowlin, Director of the Alyce de Roulet Williamson Gallery, Art Center College of Design

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Submit Your Film

Submit Your Film | Art & Science | Scoop.it
SUBMISSIONS WILL OPEN MARCH 1ST, 2013 Early Deadline (May 1, 2013) Regular Deadline (June 15, 2013) Late Deadline (August 15, 2013) [or complete our online submission form] Eligibility One or more ...
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Why Art and Science?, by Johanna Kieniewicz | At the Interface

Why Art and Science?, by Johanna Kieniewicz | At the Interface | Art & Science | Scoop.it

Linkages between art and science are proliferating, and fast, but to what end? Whether it is a formal collaboration between artists and scientists, a call for artists in residence at scientific institutions, or a simple ‘jumping on the bandwagon’ to present a gallery of research images as ‘art’, there is something in air. Some of this work is truly brilliant, some is genuinely good, and some is well intentioned, but some may well be detrimental to both art and science.

 

So, what exactly is the point of this art and science movement? For those of us who are involved in this area, and generally see collaborations between artists and scientists as a good thing, what exactly do we hope for from this brave new world? Here I present what I view to be the most compelling reasons for collaborations between artists and scientists and my vision for where I hope things might go.

...

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Call: Field_Notes – Deep Time @ ars bioarctica

Call: Field_Notes – Deep Time @ ars bioarctica | Art & Science | Scoop.it

Call for professional collaborators

       Field_Notes – Deep Time

Field_Notes – Deep Time is a week long art&science field laboratory organized by the Finnish Society of Bioart at the Kilpisjärvi Biological Station in Lapland/Finland. Five working groups, hosted by Oron Catts, Antero Kare, Leena Valkeapaa, Tere Vaden, Elisabeth Ellsworth and Jamie Kruse, together with a team of five, will develop, test and evaluate specific interdisciplinary approaches in relation to the Deep Time theme.

Field_Notes – Deep Time is in search of artistic and scientific responses to the dichotomy between human time-perception and comprehension, and the time of biological, environmental, and geological processes in which we are embedded. The local sub-Arctic nature, ecology, and geology, as well as the scientific environment and infrastructure of the Kilpisjärvi Biological Station will act as a catalyst for the work carried out.

      Dates and places:

15th – 22nd September 2013 field laboratory at the Kilpisjärvi Biological Station

23rd, 24th of September 2013 conference in Helsinki

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NSF-NEA SEAD Conference Proceedings

NSF-NEA SEAD Conference Proceedings | Art & Science | Scoop.it
On May 16 I was one of several invitees to participate in the Networking Sciences, Engineering, Arts, and Design to Confront the Hard Problems of our Time. This conference was co-hosted by the Smit...
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Nettrice Gaskins aka Renegade Futurist reports on joint NSF NEA conference, w/ Network for Sciences, Engineering, Arts, and Design

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CONSUME

CONSUME | Art & Science | Scoop.it

CONSUME CONSUME, is a group exhibition informed by my research at the intersection of art, technology and food systems. It opens at gallery@calit2 on Thursday, April 11, 2013. Projects in the galle...


Via Jules Rochielle, Amanda McDonald Crowley
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An exhibition I have curated that looks at health, food systems, the pharmaceutical industry and environmental health systems...

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Amanda McDonald Crowley's comment, April 11, 2013 11:09 AM
An exhibition I have curated that looks at health, food systems, the pharmaceutical industry and environmental health systems...
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You Can Now Build Your Own Printer That Prints Living Cells

You Can Now Build Your Own Printer That Prints Living Cells | Art & Science | Scoop.it
At this point, the TED talk of Wake Forest University researcher Anthony Atala 3-D-printing a dummy, human kidney on stage is the stuff of nerd mythology.
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Anna Dumitriu: Confronting the Bacterial Sublime: Whole Genome Sequencing, Microbiology and Bioart | MutaMorphosis: Tribute to Uncertainty

Anna Dumitriu: Confronting the Bacterial Sublime: Whole Genome Sequencing, Microbiology and Bioart | MutaMorphosis: Tribute to Uncertainty | Art & Science | Scoop.it
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Science & U! - Science & The Arts - CUNY TV

Science & U! - Science & The Arts - CUNY TV | Art & Science | Scoop.it
Science & U! this month explores the artistic side of science:Andrew Falzon talks soundwaves with Acoustician Paul Scarbrough at the Brooklyn Academy of Music.Tinabeth Pina gets a closer look at musical strings and the complexity that goes into creati...
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Nil by Mouth: Food, Farming, Science and Sustainability « CREATIVE FUTURES

Nil by Mouth: Food, Farming, Science and Sustainability « CREATIVE FUTURES | Art & Science | Scoop.it
Nil by Mouth: Food, Farming, Science and Sustainability - CREATIVE FUTURES
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The Future of Art & Science collaborations

The Future of Art & Science collaborations | Art & Science | Scoop.it
The Future of Art & Science Collaborations is a series of double lectures by eminent international researchers and practitioners from the field where art and science interact.

 

Lecture Series at Waag Society, October 2013

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CUriosity3: Conversations in Art + Science

CUriosity3: Conversations in Art + Science | Art & Science | Scoop.it
Always on the lookout for projects that explore the intersection between art + science, I was excited to learn about CUriosity3: a monthly evening series aimed at engaging the public in a conversat...
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Aquatopia | Tate

Aquatopia | Tate | Art & Science | Scoop.it

Aquatopia: The Imaginary of the Ocean Deep. Tate St Ives Exhibition with over 150 contemporary and historic artworks exploring how the deep has been imagined by artists, writers and poets.

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Linda Weintraub: To Life!

To Life! Eco Art in Pursuit of a Sustainable Planet

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Danielle Siembieda's comment, July 5, 2013 10:21 PM
Good list of artists in this book.
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HeHe, Fracking Futures, The Arts Catalyst commission at FACT Liverpool

HeHe, Fracking Futures, The Arts Catalyst commission at FACT Liverpool | Art & Science | Scoop.it
A new commission in collaboration with FACT for the exhibition Turning FACT Inside Out celebrating the last 10 years of FACT, until 15 September 2013
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Art Science Residency Program 2013 « anclab.org

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Amazing sounding Art Science residency program in Singapore w/ additional themes for 2013: Climate Change & Environmental Futures + Contemporary Asian & Future Cities.

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'Frankenstein's Cat': Bioengineering The Animals Of The Future : NPR

'Frankenstein's Cat': Bioengineering The Animals Of The Future : NPR | Art & Science | Scoop.it
Science journalist Emily Anthes talks about how scientists are engineering mice with tumors and working to create pigs that can grow organs for human transplant and insects that could serve as drones for the military.

 

""It puts animal welfare and human welfare in conflict," says Anthes. "Most thinking, feeling humans, I think, would say that they don't want animals to suffer, but a lot of us — the majority of Americans — surveys show, also accept some sort of animal research and experimentation. ... Most people, for instance, would say that they're willing to see some mice engineered to get cancer if it cures human cancer, but they're less willing to see mice suffer if we're just looking for a cure for baldness. It's really something we have to tackle on a case-by-case basis based on what the potential benefits for humans are versus the cost to the animals themselves."

Amanda McDonald Crowley's insight:

Very interesting read in relation to Beatriz da Costa's artwork, Dying for the Other.

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Art and Science - Hybrid Art and Interdisciplinary Research

Art and Science - Hybrid Art and Interdisciplinary Research

 

An international conference “Art & Science – Hybrid Art and Interdisciplinary Research” and related exhibition takes place in 2014, organized by the Graduate School of Culture Studies and Arts (GSCSA) and the Estonian Academy of Arts (EAA). The main goal is to nurture synergetic cooperation of art and science and to present a multiplicity of practices in different research fields by doctoral students, internationally renowned researchers and practitioners, and the emerging ideas regarding convergence and confluence of different disciplines.

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A personal thought on photography, art, biology and science | Society of Biology blog

A personal thought on photography, art, biology and science | Society of Biology blog | Art & Science | Scoop.it
Last year's Society of Biology photography competition winner discusses visual art, science and entries to the 2012 competition entitled How Biology Can Save the World (A personal thought on photography, art, biology and science
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