Mass spectrometry
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Rescooped by Joseval Estigaribia from Mass spectrometry
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An Integrated Mass Spectrometry‐Based Approach to Probe the Structure of the Full‐Length Wild‐Type Tetrameric p53 Tumor Suppressor

An Integrated Mass Spectrometry‐Based Approach to Probe the Structure of the Full‐Length Wild‐Type Tetrameric p53 Tumor Suppressor | Mass spectrometry | Scoop.it
We present an integrated approach for investigating the topology of proteins through native mass spectrometry (MS) and cross‐linking/MS, which we applied to the full‐length wild‐type p53 tetramer
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Recent Advances in NMR-Based Metabolomics 

Recent Advances in NMR-Based Metabolomics  | Mass spectrometry | Scoop.it
G. A. Nagana Gowda† and Daniel Raftery*†‡§
†Northwest Metabolomics Research Center, Department of Anesthesiology and Pain Medicine and ‡Department of Chemistry, University of Washington, Seattle, Washington 98109, United States,
§ Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, United States
Anal. Chem., Article ASAP
DOI: 10.1021/acs.analchem.6b04420

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NatProdChem's curator insight, December 3, 7:11 AM

What's new in NMR metabolomics.

Rescooped by Joseval Estigaribia from Natural Products Chemistry Breaking News
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Opportunistic Sampling of Roadkill as an Entry Point to Accessing Natural Products Assembled by Bacteria Associated with Non-anthropoidal Mammalian Microbiomes 

Opportunistic Sampling of Roadkill as an Entry Point to Accessing Natural Products Assembled by Bacteria Associated with Non-anthropoidal Mammalian Microbiomes  | Mass spectrometry | Scoop.it

Click hFew secondary metabolites have been reported from mammalian microbiome bacteria despite the large numbers of diverse taxa that inhabit warm-blooded higher vertebrates. As a means to investigate natural products from these microorganisms, an opportunistic sampling protocol was developed, which focused on exploring bacteria isolated from roadkill mammals. This initiative was made possible through the establishment of a newly created discovery pipeline, which couples laser ablation electrospray ionization mass spectrometry (LAESIMS) with bioassay testing, to target biologically active metabolites from microbiome-associated bacteria. To illustrate this process, this report focuses on samples obtained from the ear of a roadkill opossum (Dideiphis virginiana) as the source of two bacterial isolates (Pseudomonas sp. and Serratia sp.) that produced several new and known cyclic lipodepsipeptides (viscosin and serrawettins, respectively). These natural products inhibited biofilm formation by the human pathogenic yeast Candida albicans at concentrations well below those required to inhibit yeast viability. Phylogenetic analysis of 16S rRNA gene sequence libraries revealed the presence of diverse microbial communities associated with different sites throughout the opossum carcass. A putative biosynthetic pathway responsible for the production of the new serrawettin analogues was identified by sequencing the genome of the Serratia sp. isolate. This study provides a functional roadmap to carrying out the systematic investigation of the genomic, microbiological, and chemical parameters related to the production of natural products made by bacteria associated with non-anthropoidal mammalian microbiomes. Discoveries emerging from these studies are anticipated to provide a working framework for efforts aimed at augmenting microbiomes to deliver beneficial natural products to a host.ere to edit the content


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NatProdChem's curator insight, November 27, 10:15 AM

Weirdest sampling pipeline !

Rescooped by Joseval Estigaribia from Article On Chemistry - Find Out Chemical Industry Best Articles only at World Of Chemicals
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Role of Oxalic Acid in Human Body | List of Oxalic Acid Foods

Role of Oxalic Acid in Human Body |  List of Oxalic Acid Foods | Mass spectrometry | Scoop.it
Oxalic Acid belonging to the family of carboxylic acids and this chemical also termed as Ethanedioic Acid. Oxalic acid is widely used as an acid rinse in laundries, where it can able to remove rust and ink stains because of its capability of converting insoluble iron compounds into a soluble complex ion.For the same reason, it is the chief ingredient of many commercial preparations used for removing scale from automobile radiators. It occurs naturally in high levels in many common foods, including several vegetables like Potatoes, Beets, Broccoli, Carrots and other foods like fruits, nuts&seeds, legumes&grains, Chocolate, Beer etc. In some of these food items, it tastes pleasantly sour, and in others it’s essentially tasteless. Because it binds with some nutrients making them unavailable, for this reason the oxalic acid is often described as an anti-nutrient. We don’t believe oxalic acid poses a health threat if you’re reasonable about your consumption. More than 90 per cent of the oxalic acid you consume is normally excreted in your urine. Organic form of oxalic acid, in low concentration, is essential to maintain peristaltic motion in our body. However, when it is processed or cooked, it becomes inorganic form, and may have certain negative effects on the body. Foods high in both calcium and oxalic acid are less of a concern than those merely high in oxalic acid, since the calcium bonds with the oxalic acid in the stomach. In lower doses, oxalic acid can limiting the absorption of some nutrients, particularly calcium and iron. When oxalic acid combines with calcium and some of these other minerals it creates oxalate crystals, which can contribute to kidney stones, gout etc. Oxalic acid can also interfere with the absorption of minerals in our diet such as calcium, potassium, and magnesium. Hence, it is advisable for people with certain health conditions to limit its intake through the diet. One thing to be kept in mind is that, oxalic acid is harmless if consumed in organic form and moderate amounts. However, too much of it can have several adverse effects on your body.

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Chemical Analysis, Mass Spectrometry, Helps Identify Substances

Chemical Analysis, Mass Spectrometry, Helps Identify Substances | Mass spectrometry | Scoop.it
Name that chemical! Scientists use chemical analysis - Mass Spectrometry, Raman Spectroscopy, and more - to determine the identity of chemical residues.
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Ion Mobility-Mass Spectrometry as a Tool for the Structural Characterization of Peptides Bearing Intramolecular Disulfide Bond(s)

Ion Mobility-Mass Spectrometry as a Tool for the Structural Characterization of Peptides Bearing Intramolecular Disulfide Bond(s) | Mass spectrometry | Scoop.it
Disulfide bonds are post-translationnal modifications that can be crucial for the stability and the biological activities of natural peptides. Considering the importance of these disulfide bond-contai

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Characterization of Indium Phosphide Quantum Dot Growth Intermediates Using MALDI-TOF Mass Spectrometry - Journal of the American Chemical Society (ACS Publications)

Characterization of Indium Phosphide Quantum Dot Growth Intermediates Using MALDI-TOF Mass Spectrometry - Journal of the American Chemical Society (ACS Publications) | Mass spectrometry | Scoop.it

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The Art of Destruction: Optimizing Collision Energies in Quadrupole-Time of Flight (Q-TOF) Instruments for Glycopeptide-Based Glycoproteomics - Online First - Springer

The Art of Destruction: Optimizing Collision Energies in Quadrupole-Time of Flight (Q-TOF) Instruments for Glycopeptide-Based Glycoproteomics - Online First - Springer | Mass spectrometry | Scoop.it

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Rescooped by Joseval Estigaribia from Article On Chemistry - Find Out Chemical Industry Best Articles only at World Of Chemicals
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Why Cellulase Important in Stone Washing! - World Of Chemicals

Why Cellulase Important in Stone Washing! - World Of Chemicals | Mass spectrometry | Scoop.it
Stonewashing process is one of the textile manufacturing processes used to give a newly manufactured cloth garment a worn-in or worn-out appearance. Stonewashing process can benefit in various methods like to increase the softness and flexibility of stiff and rigid fabrics such as canvas and denim jeans.

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Great significances of oxygen - World Of Chemicals

Great significances of oxygen - World Of Chemicals | Mass spectrometry | Scoop.it
Oxygen isolated by joseph priestley oxygen comprises 22 per cent of the atmospheric air Oxygen is produced using air separation plants used in various industrial applications steel production, rocket propellants, medicine

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Safe Cosmetics for Beautiful Makeovers

Safe Cosmetics for Beautiful Makeovers | Mass spectrometry | Scoop.it
Here are few tips to choose your cosmetics wisely Look for certified lables on the cosmetics you purchase Learn to read the ingredients listed on the lable Check for the composition on the product, avoid buying beauty products with heavy metals, parabens, phalates and 1,4 dioxane to name a few Do not purchase beauty and personal care products on heavy discounts Never use the products that have crossed their expiry dates Switching to organic make-up products is another alternative Why not choose home remedies?

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Benzene: A carcinogen found in soft drink | People falling Sick after having carbonated drinks or soft drinks

Benzene: A carcinogen found in soft drink | People falling Sick after having carbonated drinks or soft drinks | Mass spectrometry | Scoop.it

Within 20 minutes of drinking a soft drink blood sugar spikes and your liver responds to the resulting insulin burst by turning massive amounts of sugar into fat. The continuing insulin burst, over time, eventually creates insulin resistance and finally diabetes can be the result.


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8,400 - 10,000 chemicals in tobacco smoke!

8,400 - 10,000 chemicals in tobacco smoke! | Mass spectrometry | Scoop.it
Carbon monoxide is the main poisonous gas in car exhausts as well as present in cigarette smoke It binds to haemoglobin much more readily than oxygen, thus causing the blood to carry less oxygen. Not just tobacco, there are several harmful chemicals in cigarettes, some of which are poisonous Other chemicals effect include

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An Integrated Mass Spectrometry‐Based Approach to Probe the Structure of the Full‐Length Wild‐Type Tetrameric p53 Tumor Suppressor

An Integrated Mass Spectrometry‐Based Approach to Probe the Structure of the Full‐Length Wild‐Type Tetrameric p53 Tumor Suppressor | Mass spectrometry | Scoop.it
We present an integrated approach for investigating the topology of proteins through native mass spectrometry (MS) and cross‐linking/MS, which we applied to the full‐length wild‐type p53 tetramer
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How is bromine synthesised by laboratory process? - World Of Chemicals

How is bromine synthesised by laboratory process? - World Of Chemicals | Mass spectrometry | Scoop.it
To make bromine in the laboratory here are few steps we need to follow; we need to find a chlorine source and react it with a solution of bromide ions. After formation of the bromine, it must be separated from the solution in a suitable way

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Rescooped by Joseval Estigaribia from Mass Spectrometry at Bruker
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Bruker BRKR Infrared ion spectroscopy in a modified quadrupole ion trap mass spectrometer - FELIX free electron laser laboratory

We report on modifications made to a Paul-type quadrupole ion trap
mass spectrometer and discuss its application in infrared ion spectroscopy experiments. Main modifications involve optical access to the trapped ions and hardware and software coupling to a variety of infrared laser sources at the FELIX infrared free electron laser laboratory. In comparison to previously described infrared ion spectroscopy experiments at the FELIX laboratory, we find significant improvements in efficiency and sensitivity. Effects of the trapping conditions of the ions on the IR multiple photon dissociation
spectra are explored. Enhanced photo-dissociation is found at lower pressures in the ion trap.
Spectra obtained under reduced pressure conditions are found to more closely mimic those obtained in the high-vacuum conditions of an Fourier transform ion cyclotron resonance mass spectrometer. A gas-mixing system is described enabling the controlled addition of a secondary gas into helium buffer gas flowing into the trap and allows for ion/molecule reactions in the trap. The electron transfer dissociation (ETD) option of the mass spectrometer allows for IR structure characterization of ETD-generated peptide dissociation products.

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Chemical Analysis, Mass Spectrometry, Helps Identify Substances

Chemical Analysis, Mass Spectrometry, Helps Identify Substances | Mass spectrometry | Scoop.it
Name that chemical! Scientists use chemical analysis - Mass Spectrometry, Raman Spectroscopy, and more - to determine the identity of chemical residues.
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Accurate drift time determination by traveling wave ion mobility spectrometry: The concept of the diffusion calibration - Analytical Chemistry (ACS Publications)

Accurate drift time determination by traveling wave ion mobility spectrometry: The concept of the diffusion calibration - Analytical Chemistry (ACS Publications) | Mass spectrometry | Scoop.it

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Preliminary MALDI-TOF-MS analysis of seminal plasma N-glycome of infertile men.

Glycosylation pattern within reproductive tract is now suggested to be involved in providing female immune tolerance for allograft sperm and developing embryo, but the information whether impaired glycosylation may influence male fertility...
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LUMC: automated High-Throughput Permethylation for Glycosylation Analysis of Biologics Using MALDI-TOF-MS - Analytical Chemistry (ACS Publications)

LUMC: automated High-Throughput Permethylation for Glycosylation Analysis of Biologics Using MALDI-TOF-MS - Analytical Chemistry (ACS Publications) | Mass spectrometry | Scoop.it

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Chemical Formulae Diversity & Complexity of Scotch Whisky - Mass Spectrometry solariX Bruker #FTICR

Chemical Formulae Diversity & Complexity of Scotch Whisky - Mass Spectrometry solariX Bruker #FTICR | Mass spectrometry | Scoop.it
Scotch Whisky is an important product, both culturally and economically. Chemically, Scotch Whisky is a complex mixture, which comprises thousands of compounds, the nature of which are largely unknown

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pvanhouts's curator insight, November 2, 6:21 AM

Beautifull and very well executed example of the use of molecular Isotopic Fine Structures in very complex samples (Scotch Whisky, in this example), to gain insights into the detailed chemical processes. Some of the chemical differences found between Scotch whisky's could be directly related to the ageing, and even the wood of the barrels, used to create the specific whisky flavors.


In essence, this work is along the same lines of research in the Petrol/Petroleomics industry, where these mass spectrometry methods are being used now to study for instance crude oil. Similar methods are starting to be used in several clinical and pharmaceutical analysis, and many other fields.

Together with the already established methods to look at food authenticity with magnetic resonance (NMR - see Bruker wine screener and honey screener products), my personal prediction is that the way we look chemically at all kinds of products will hugely benefit from using these Isotopic Fine Structures to determine these thousands of Chemical Formulae in a very fast way.

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Celebrating Mole Day to foster interest in chemistry - World Of Chemicals

Celebrating Mole Day to foster interest in chemistry - World Of Chemicals | Mass spectrometry | Scoop.it
Mole Day celebrated annually on October 23 from 6:02 a.m. to 6:02 p.m. commemorates Avogadro’s Number (6.02 x 1023), which is a basic measuring unit in chemistry

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Chemistry of Teflon Cookware - World Of Chemicals

Chemistry of Teflon Cookware - World Of Chemicals | Mass spectrometry | Scoop.it
Let me give you the common name of Polytetrafluoroethylene i.e., “Teflon” Teflon is generally used for non-stick cookware. The non-stick cookware coating allows food to brown without sticking to the pan

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Why Chillies are so Hot? Read the Chemistry behind Red Hot Chillies

Why Chillies are so Hot? Read the Chemistry behind Red Hot Chillies | Mass spectrometry | Scoop.it
When you’ve eaten spicy food in precise chillies you will get tears in your eyes, and your mouth feels burning sensation and as a course of action spontaneously you will have a glass of water to suppress the hotness. But still after having a glass of water you feel to drink more water! All this kind of taste, burning sensation and heat on your tongue is due to a chemical named ‘Capsaicin’ which is present in chillies.

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Interesting facts about nitrogen element - World Of Chemicals

Interesting facts about nitrogen element - World Of Chemicals | Mass spectrometry | Scoop.it
Nitrogen chemical element represented as N and atomic number of 7, nitrogen used in various industrial and commercial applications such as fertilizers, packaged foods, Light Bulbs, Reactive compounds production

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