MERRITT ISLAND, Fla. - Unlike the alligators of urban legend that lurk in Manhattan’s sewers, a real-life reptile took up residence in a drain pipe in an otherwise quiet neighborhood near the Ulamay Wildlife Sanctuary -- belching menacing, rumbling hisses at passers-by.
Since December, the alligator inhabited the grated end of a stormwater pipe off Lakewood Circle. And nearby humans feared for the animal’s health and safety.
Neighborhood guesstimates of the gator’s length ranged from 4 to 10 feet -- only the fearsome, scaly snout was typically visible, poking out of the pipe. Whatever its length, the toothy reptile apparently was not happy with its living situation.
Hours later, the reptile was removed. Florida Fish and Wildlife Conservation Commission officers used plastic piping to coax the 7-foot gator to backpedal -- “he wasn’t at all happy about it,” spokeswoman Joy Hill described -- and the beast was captured soon afterward.
The alligator was relocated to a St. Johns River marsh, Hill said.
The FWC’s Statewide Nuisance Alligator Program received 14,275 nuisance alligator complaints in 2011, and 6,995 gators were removed...
Researchers at the Universitat Autónoma de Barcelona have succeeded in completely curing type 1 diabetes in dogs with a single session of gene therapy. This is the first time that the disease has been cured in large animals, a fundamental step towards applying the therapy in humans. The study, based on introducing a "glucose sensor" into muscle, has been published in Diabetes, the most prestigious journal in this field.
Researchers from the Universitat Autònoma de Barcelona (UAB), led by Fátima Bosch, have shown for the first time that it is possible to cure diabetes in large animals with a single session of gene therapy. As published this week in Diabetes, the principal journal for research on the disease, after a single gene therapy session, the dogs recover their health and no longer show symptoms of the disease. In some cases, monitoring continued for over four years, with no recurrence of symptoms.
The therapy is minimally invasive. It consists of a single session of various injections in the animal's rear legs using simple needles that are commonly used in cosmetic treatments. These injections introduce gene therapy vectors, with a dual objective: to express the insulin gene, on the one hand, and that of glucokinase, on the other. Glucokinase is an enzyme that regulates the uptake of glucose from the blood. When both genes act simultaneously they function as a "glucose sensor", which automatically regulates the uptake of glucose from the blood, thus reducing diabetic hyperglycemia (the excess of blood sugar associated with the disease).
As Fátima Bosch, the head researcher, points out, "this study is the first to demonstrate a long-term cure for diabetes in a large animal model using gene therapy.”
This same research group had already tested this type of therapy on mice, but the excellent results obtained for the first time with large animals lays the foundations for the clinical translation of this gene therapy approach to veterinary medicine and eventually to diabetic patients.
The study was led by the head of the UAB's Centre for Animal Biotechnology and Gene Therapy (CBATEG) Fàtima Bosch, and involved the Department of Biochemistry and Molecular Biology of the UAB, the Department of Medicine and Animal Surgery of the UAB, the Faculty of Veterinary Science of the UAB, the Department of Animal Health and Anatomy of the UAB, the Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), the Children’s Hospital of Philadelphia (USA) and the Howard Hughes Medical Institute of Philadelphia (USA).
The study provides ample data showing the safety of gene therapy mediated by adeno-associated vectors (AAV) in diabetic dogs. The therapy has proved to be safe and efficacious: it is based on the transfer of two genes to the muscle of adult animals using a new generation of very safe vectors known as adeno-associated vectors. These vectors, derived from non-pathogenic viruses, are widely used in gene therapy and have been successful in treating several diseases.
In fact, the first gene therapy medicine ever approved by the European Medicines Agency, named Glybera®, makes use of adeno-associated vectors to treat a metabolic disease caused by a deficiency of lipoprotein lipase and the resulting accumulation of triglycerides in the blood.
it is the first time autonma de barcelona have cured type 1 diabetes. They cured it in dogs with a single session of gene therapy. It is the first time it has been cured in a large animal. It is a fundamental step to humans. After the gene session the dogs recover there health and show no more symptoms of type 1 diabetes. They tested in mice aready it was the same.
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