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Quantum Hypercube Memory will Enable Distributed Parallel Small Quantum Computers to Provide Exponential Speed up over Classical Computing

Quantum Hypercube Memory will Enable Distributed Parallel Small Quantum Computers to Provide Exponential Speed up over Classical Computing | Amazing Science | Scoop.it

A quantum computer doesn't need to be a single large device but could be built from a network of small parts, new research from the University of Bristol has demonstrated. As a result, building such a computer would be easier to achieve.

Many groups of research scientists around the world are trying to build a quantum computer to run algorithms that take advantage of the strange effects of quantum mechanics such as entanglement and superposition. A quantum computer could solve problems in chemistry by simulating many body quantum systems, or break modern cryptographic schemes by quickly factorising large numbers.

Previous research shows that if a quantum algorithm is to offer an exponential speed-up over classical computing, there must be a large entangled state at some point in the computation and it was widely believed that this translates into requiring a single large device.

In a paper published in the Proceedings of the Royal Society A, Dr Steve Brierley of Bristol's School of Mathematics and colleagues show that, in fact, this is not the case. A network of small quantum computers can implement any quantum algorithm with a small overhead.

The key breakthrough was learning how to efficiently move quantum data between the many sites without causing a collision or destroying the delicate superposition needed in the computation. This allows the different sites to communicate with each other during the computation in much the same way a parallel classical computer would do.

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Mercor's curator insight, February 26, 2013 10:10 AM

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20,000+ FREE Online Science and Technology Lectures from Top Universities

20,000+ FREE Online Science and Technology Lectures from Top Universities | Amazing Science | Scoop.it

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Casper Pieters's curator insight, March 9, 7:21 PM

Great resources for online learning just about everything.  All you need is will power and self- discipline.

Russ Roberts's curator insight, April 23, 11:37 PM

A very interesting site.  Amazing Science covers many disciplines.  Subscribe to the news letter and be " amazed." Aloha, Russ, KH6JRM. 

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Your knowledge is your strength and power 

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Fusion Lasers Compress Diamond To Pressures Of 50 Million Earth Atmospheres (5 Terapascals)

Fusion Lasers Compress Diamond To Pressures Of 50 Million Earth Atmospheres (5 Terapascals) | Amazing Science | Scoop.it

Physicists reported recently that they have successfully used the lasers built for fusion reactions at the National Ignition Facilityin Lawrence Livermore National Laboratory to compress a synthetic diamond to pressures of 50 million Earth atmospheres (5 terapascals).  For the first time scientists measured pressure-density curves of matter at trillion pascal pressures, an extreme environment found in the core of gas giants and super Earth planets.


A tiny sample of synthetic diamond, millimeter-sized and in the shape of a cylinder, was held upright and put into the crosshairs of 176 high powered fusion laser beams.  The beams have total peak power of 2200 gigawatts (GW).  In comparison, a nuclear power plant only produces as much as energy at a rate of 0.5 to 2 GW.  Since power is the energy output over time, the laser beams can only run a very short time at such power, so the total output of energy is not high.


Half the beams are focused on the top half of the cylinder and the other half on the bottom.  This squeezes the cylinder when the lasers fire.  Upon firing, the physicists measured the rate of diamond material moving under the tremendous heating and counter-reactions.  As the cylindrical piece of diamond is compressed, its middle bulges out at extremely high velocities.  The measured peak velocity was 109,000 miles per hour, or about 45 kilometers per second.


They found that at the peak pressure of 5 trillion pascals, or equivalently 50 million Earth atmospheres, the density of the diamond had more than tripled.  Therefore the diamond was compressed to three times a smaller volume than before, making its density equal to that of lead.


The results were compared to a type of computer simulation called density functional theory (DFT).  DFT is based on a branch of physics known as quantum mechanics.  While it is an approximate method, meaning that accuracy of representing the underlying physics is sacrificed for purposes of speed, it is quite successful in predicting many complex aspects of matter.  The researchers used two types of theories in DFT and showed that the measured results fall right in between the computer predictions.

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Flexible solar cells woven into fabric could power wearable electronics

Flexible solar cells woven into fabric could power wearable electronics | Amazing Science | Scoop.it

Wearable electronics are quickly becoming the fashion. And there could soon be a way to power those electronics indefinitely, now that scientists in China have developed a solar cell ‘textile’ that could be woven into clothes. The textile retains a power-generation efficiency close to 1% even after been bent more than 200 times, and can be illuminated from both sides.


Scientists have been looking into flexible solar cells for decades, partly for coating irregularly shaped objects but also for integrating into wearable fabrics. One popular line of investigation has been dye-sensitized solar cells, in which a pigment absorbs sunlight to generate electrons and their positive counterparts, holes, before passing on those charges to inexpensive semiconductors. These solar cells are cheap and flexible, but the liquid nature of their pigments means that they must be well sealed. Bend a dye-sensitized solar cell more than a few times and the seals are likely to break, destroying its light-harvesting properties.


That is why Huisheng Peng at Fudan University in Shanghai and colleagues have been exploring another option: polymer solar cells. Although their maximum efficiencies fall below 10% – about half that of crystalline silicon, the most prevalent solar cell – polymer solar cells are lightweight, flexible and easy to manufacture. Peng and colleagues’ solar cell textile consists of microscopic interwoven metal wires coated with an active polymer (to absorb the sunlight), titanium dioxide nanotubes (to conduct the electrons) and another active polymer (to conduct the holes). The researches coated each side of the textile with transparent, conductive sheets of carbon nanotubes, which complete the circuit.


Because of the textile’s symmetry, the cell can be illuminated on either side. In tests it exhibited a maximum efficiency of 1.08%, which varied by less than 0.03% after 200 cycles of bending. However, the textile is currently only about the size of a fingernail. ‘The main difficulties encountered are how to scale up the solar-cell textile while maintaining high energy-conversion efficiencies,’ says Peng.


Materials scientist Anyuan Cao, who was not involved with the work, believes the results are interesting, particularly the use of carbon nanotube sheets to allow illumination from both sides. But he warns that wearable solar cells are still some way off. ‘Current textiles demonstrated in laboratories are too small and have low energy conversion efficiencies,’ says Cao, who is based at Peking University in China.


‘The materials involved and the fabrication processes are still expensive. Practical use not only requires that the textiles should withstand simple bending, but also that they should sustain much more complex deformations such as folding and twisting, even under dynamic conditions.’


Z Zhang et alAngew. Chem., Int. Ed., 2014, DOI: 10.1002/anie.201407688

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An end to drug errors? Eliminate medication errors with intelligent scanning system

An end to drug errors? Eliminate medication errors with intelligent scanning system | Amazing Science | Scoop.it
Mint Solutions tackles medication errors with scanning system that ensures patients get the right pills.


MIT alumni entrepreneurs Gauti Reynisson MBA ’10 and Ívar Helgason HS ’08 spent the early 2000s working for companies that implemented medication-safety technologies — such as electronic-prescription and pill-barcoding systems — at hospitals in their native Iceland and other European countries.


But all that time spent in hospitals soon opened their eyes to a major health care issue: Surprisingly often, patients receive the wrong medications. Indeed, a 2006 report from the Institute of Medicine found that 1.5 million hospitalized patients in the United States experience medication errors every year due, in part, to drug-administration mistakes. Some cases have adverse or fatal results.


Frustrated and seeking a solution, the Icelandic duo quit their careers and traveled to MIT for inspiration. There, they teamed up with María Rúnarsdóttir MBA ’08 and devised MedEye, a bedside medication-scanning system that uses computer vision to identify pills and check them against medication records, to ensure that a patient gets the right drug and dosage.


Commercialized through startup Mint Solutions, MedEye has now been used for a year in hospitals in the Netherlands (where the startup is based), garnering significant attention from the medical community. Through this Dutch use, the co-founders have determined that roughly 10 percent of MedEye’s scans catch medication errors.


“Medication verification is a pinnacle point of medical safety,” says Helgason, a physician and product developer. “It’s a complicated chain of events that leads up to medication mistakes. But the bedside is the last possible place to stop these mistakes.”


Mint Solutions’ aim, Reynisson says, is to aid nurses in rapidly, efficiently, and correctly administering medication. “We want the device to be the nurse’s best friend,” says Reynisson, now Mint’s CEO. The device, he adds, could yield savings by averting medication mishaps, which can cost hundreds of millions of dollars.

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Parasitic Plant Strangleweed Injects Host With Over 9,000 RNA Transcripts

Parasitic Plant Strangleweed Injects Host With Over 9,000 RNA Transcripts | Amazing Science | Scoop.it

Virginia Tech professor and Fralin Life Institute affiliate Jim Westwood has made a discovery about plant-to-plant communication: enormous amounts of genetic messages in the form of mRNA transcripts are transmitted from the parasitic plant Cuscuta (known more commonly as dodder and strangleweed) to its hosts.


Using Illumina next generation sequencing technologies to sequence the tissues of the host and an attached parasite, the team found that the number of genes that gets passed into the host depends on the identity of the host.  The tomato plant received 347 of the strangleweed’s mRNAs, whereas the Arabidopsis received an astonishing 9514 mRNAs.  When Arabidopsis plant receives this many mRNAs, the total genetic material of tissues in contact with the strangleweed is about 45% from the parasite.


The new quantitative result builds on Professor Westwood’s prior discovery of RNA transfer between the parasitic plant and its host plants.  In the prior study, Westwood found that when the strangleweed uses its haustorium (piercing appendage) to penetrate the stems of its host plants, it passes on its own RNA to the host, though only tens of mRNAs were identified.  The discovery challenged our understanding that mRNAs are mainly kept within cells.


But now the research team has quantified the extent to which the messages are passed.  mRNA stands for “messenger RNA” and are the snippets of genetic information that are created from DNA.  Typically an mRNA molecule is “read” by a molecule machine known as a ribosome and turned into a protein which carries out particular functions in the cell.  And usually, more mRNAs means more protein.  Therefore, the conversion from DNA to mRNA is one way to amplify or control the activation of a gene.


It is not yet clear what are the functions of the transmitted genes but bioinformatic analysis shows that hydrolase activity, metabolism and response to stimulus gene groups were among the most represented in those that crossed the species bridge.


Westwood has determined that the host plant may be receiving orders of a kind from the parasitic plant, such as lowering its natural defense system so that the strangleweed can more easily attack them.


The findings by Westwood, Professor of weed science, plant pathology and physiology at the College of Agriculture and Life Sciences, is even more surprising when considered against prior thought that mRNA is unstable, short-lived and fragile.


The discoveries also opens new avenues in the research of the eradication of parasitic plants such as broomrape and witchweed, two plants that pose serious threats to legumes and other crops.  This also has intriguing implications for increasing efficiency of yields.


Future plans include expansion of such research to other organismal domains, such as fungi and bacteria, also exchange the mRNA.  But the meaning and the outcome of the transmitted messages remain yet unclear and work must be done to find out what the plants are saying to each other.

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New invisible ink: Stretchy plastics hide secret pictures

New invisible ink: Stretchy plastics hide secret pictures | Amazing Science | Scoop.it

A new invisible ink that reveals secret messages when squeezed could be useful in preventing fraud.


It could be the ultimate stress ball for spies. An invisible ink creates secret messages on bendy plastic that are only revealed when you give it a squeeze.


Previously, Jianping Ge of the East China Normal University in Shanghai, China, and his colleagues created invisible inks that appear when submerged underwater or exposed to a magnetic field. Now they've made an ink you can reveal just by squeezing with your hand. The team first embedded an array of silica crystals in a plastic gel. The crystals reflect light at a certain wavelength depending on their spacing and the angle of viewing, so the relaxed gel appears green, but squeezing or stretching it turns it red or blue.


Next, the team coated the surface with another clear plastic gel, and put a cut-out template of a secret image on top. They shone ultraviolet light on the set-up, which linked the two gels around the cut-out, but left them separate in the parts covered by the template. The linked gels are firmer, so they don't change colours when squeezed. After the cut-out was removed, its silhouette only appeared when the gels were squeezed.


Ge says he is talking to companies about using the technique to protect against counterfeit goods. "These invisible photonic patterns can be potential anti-fake labels," he says. Jon Kellar, a materials engineer at the South Dakota School of Mines and Technology in Rapid City, South Dakota, agrees that the hidden images could help combat fraud, but he thinks that the fabrication process will need to be simplified for commercial use.

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Chromatophagy, A New Cancer Therapy: Starve The Diseased Cell Until It Eats Its Own DNA

Chromatophagy, A New Cancer Therapy: Starve The Diseased Cell Until It Eats Its Own DNA | Amazing Science | Scoop.it

Nutritional starvation therapy is under intensive investigation because it provides a potentially lower toxicity with higher specificity than conventional cancer therapy. Autophagy, often triggered by starvation, represents an energy-saving, pro-survival cellular function; however, dysregulated autophagy could also lead to cell death, a process distinct from the classic caspase-dependent apoptosis.


A recent study shows how arginine starvation specifically kills tumor cells by a novel mechanism involving mitochondria dysfunction, reactive oxygen species generation, DNA leakage, and chromatin autophagy, where leaked DNA is captured by giant autophagosomes. 


Cells when stressed, whether cancerous or not, undergo a process of cellular suicide that involves controlled dismantling of its interior components such as proteins, DNA, and various compartments.  By far the most famous of such processes is “apoptosis”.  The authors in this study have found another, distinct process involving mitochondria dysfunction, reactive oxygen species (ROS) generation, DNA leakage, and chromatin autophagy.


The senior author, Professor Hsing-Jien Kung, both a cancer biology at UC Davis and  the Director of the National Health Research Institutes in Taipei, Taiwan, first discovered in 2009 the basic mechanism by which arginine shortage kills cancer cells.


“Traditional cancer therapies involve ‘poisoning‘ by toxic chemicals or ‘burning‘ by radiation cancer cells to death, which often have side effects,” according to Professor Kung. “An emerging strategy is to ‘starve’ cancer cells to death, taking advantage of the different metabolic requirements of normal and cancer cells. This approach is generally milder, but as this study illustrates, it also utilizes a different death mechanism, which may complement the killing effects of the conventional therapy.”


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AdnanD's curator insight, August 29, 12:29 PM

The perseverance of man kind ! 

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Preclinical Study Shows Microbicide Gel’s Effectiveness Against HIV and Other Viruses

Preclinical Study Shows Microbicide Gel’s Effectiveness Against HIV and Other Viruses | Amazing Science | Scoop.it

Results of a recent animal study offer new optimism for microbicides, biomedical products being developed to protect people against sexually transmitted infections (STIs), including HIV. Population Council scientists and their partners have found that a proprietary microbicide gel developed by the Council is safe, stable, and can prevent the transmission of HIV, herpes simplex virus 2 (HSV-2), and human papillomavirus (HPV), in both the vagina and rectum in animals. It has a window of efficacy in the vagina against all three viruses of at least eight hours prior to exposure. An in vitro study also provides the first data that the gel is effective against multiple strains of HIV.


The gel, known as MZC, contains MIV-150, zinc acetate, and carrageenan. MIV-150 and zinc acetate are potent antiviral agents that inhibit HIV via different mechanisms of action. MIV-150 is an enzyme inhibitor that blocks an early step of HIV replication in target cells, and zinc acetate is an antiviral agent with demonstrated activity against HIV and HSV-2. These compounds are mixed in a water-based solution of carrageenan, a compound derived from seaweed that has been shown to have potent activity against HPV. Infection with HSV-2 or HPV is associated with increased risk of HIV infection. Researchers believe that microbicides that target HIV, HSV-2, and HPV may more effectively limit HIV transmission than those that target HIV alone.


In this study, Council scientists and their partners used macaque and mouse models to examine whether MZC gel could prevent vaginal and rectal transmission of SHIV-RT (a virus combining genes from HIV and SIV, the monkey version of HIV), HSV-2, and HPV. 


They found that MZC:

  • protected macaques against vaginal SHIV-RT infection when applied up to 8 hours prior to challenge
  • protected macaques against rectal SHIV-RT infection when used close to the time of viral challenge
  • protected mice against HSV-2 infection when applied vaginally or anally/rectally just before a high dose of virus
  • protected mice against HSV-2 when applied between 8 hours before and 4 hours after vaginal challenge with a low dose of HSV-2
  • protected mice against HPV when applied up to 24 hours before and 2 hours after vaginal challenge and also if applied 2 hours before or after HPV inoculation of the anus/rectum.


The study was designed to establish proof of concept in monkeys and mice before taking steps to test in humans. Preclinical testing in animals is required by the FDA and is important to ensure the highest level of safety and to build the evidence base for potential efficacy in humans. Phase 1 safety trials of the gel in humans are now underway.


“In addition to the gel,” said Fernández-Romero, “we are exploring sustained-release intravaginal rings and on-demand nanofiber-based delivery systems for MZC.” He stressed that developing different delivery systems for effective medications is an important step in ensuring the ultimate success of any microbicide, adding, “There is a growing demand for microbicides that prevent multiple STIs, and we are committed to ensuring that women and men have options when choosing what works most effectively for their own protection.”

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Introducing the multi-tasking nanoparticle for diagnostic and therapeutic applications

Introducing the multi-tasking nanoparticle for diagnostic and therapeutic applications | Amazing Science | Scoop.it

Kit Lam and colleagues from UC Davis and other institutions have created dynamic nanoparticles (NPs) that could provide an arsenal of applications to diagnose and treat cancer. Built on an easy-to-make polymer, these particles can be used as contrast agents to light up tumors for MRI and PET scans or deliver chemo and other therapies to destroy tumors. In addition, the particles are biocompatible and have shown no toxicity. The study was published online today in Nature Communications.


“These are amazingly useful particles,” noted co-first author Yuanpei Li, a research faculty member in the Lam laboratory. “As a contrast agent, they make tumors easier to see on MRI and other scans. We can also use them as vehicles to deliver chemotherapy directly to tumors; apply light to make the nanoparticles release singlet oxygen (photodynamic therapy) or use a laser to heat them (photothermal therapy) – all proven ways to destroy tumors.”


Jessica Tucker, program director of Drug and Gene Delivery and Devices at the National Institute of Biomedical Imaging and Bioengineering, which is part of the National Institutes of Health, said the approach outlined in the study has the ability to combine both imaging and therapeutic applications in a single platform, which has been difficult to achieve, especially in an organic, and therefore biocompatible, vehicle.


"This is especially valuable in cancer treatment, where targeted treatment to tumor cells, and the reduction of lethal effects in normal cells, is so critical,” she added.


 Though not the first nanoparticles, these may be the most versatile. Other particles are good at some tasks but not others. Non-organic particles, such as quantum dots or gold-based materials, work well as diagnostic tools but have safety issues. Organic probes are biocompatible and can deliver drugs but lack imaging or phototherapy applications.


Built on a porphyrin/cholic acid polymer, the nanoparticles are simple to make and perform well in the body. Porphyrins are common organic compounds. Cholic acid is produced by the liver.


To further stabilize the particles, the researchers added the amino acid cysteine (creating CNPs), which prevents them from prematurely releasing their therapeutic payload when exposed to blood proteins and other barriers. At 32 nanometers, CNPs are ideally sized to penetrate tumors, accumulating among cancer cells while sparing healthy tissue.


In the study, the team tested the nanoparticles, both in vitro and in vivo, for a wide range of tasks. On the therapeutic side, CNPs effectively transported anti-cancer drugs, such as doxorubicin. Even when kept in blood for many hours, CNPs only released small amounts of the drug; however, when exposed to light or agents such as glutathione, they readily released their payloads. The ability to precisely control chemotherapy release inside tumors could greatly reduce toxicity. CNPs carrying doxorubicin provided excellent cancer control in animals, with minimal side effects.

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World’s Smallest Standalone 3G Modem Aims to Make Large Impact on the Internet of Things

World’s Smallest Standalone 3G Modem Aims to Make Large Impact on the Internet of Things | Amazing Science | Scoop.it

There are already smartwatches and other wearables with cellular data built-in, but the bulky hardware they need for that wireless access makes them less than elegant. Intel clearly isn't happy with this state of affairs, as it just unveiled an extra-tiny modem that should put truly sleek, always-connected devices on your body -- and seemingly everywhere else. The new XMM 6255 isn't much larger than a penny (0.47 square inches), but delivers a full-fledged 3G data link. It's built to take abuses like power spikes, and it doesn't need a big antenna to get a good connection; it can even get solid performance in a low-signal area like your basement.


XMM™ 6255 features the SMARTI™ UE2p transceiver, which is based on our unique new Intel® Power Transceiver technology, the industry’s first design to combine transmit & receive functionality with a fully integrated power amplifier and power management, all on a single chip. This design approach reduces XMM™ 6255’s component requirements, resulting in a smaller modem that helps manufacturers minimize their build of material costs. It also protects the radio from overheating, voltage peaks and damage under tough usage conditions, which is important for safety monitors and other critical IoT devices.


Additionally, the XMM™ 6255 modem features a unique radio architecture that enables it to perform exceptionally well in challenging real-world situations, including:

  • Low signal network coverage: The XMM™ 6255 modem provides reliable communication when it comes to transmitting information in low signal zones like a parking garage or a home basement.
  • Small-sized devices: Devices with a small form factor like a smartwatch or a sensor may not have enough space for a normal-sized 3G antenna, which can affect connectivity quality and reliability. The XMM™ 6255 modem is specially designed for such devices and delivers great 3G connectivity even with small volume antennas not meeting conventional mobile phone quality standards.



The company isn't ready to say just who's using the miniscule modem in finished products, but the technology could be relatively ubiquitous. Besides more wearables that don't have to rely on your phone to get online, you could see a larger internet of things where even relatively small devices have their own internet service; it's reasonable to expect a lot of smart sensors and security systems that can always talk to the outside world.

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Cloud Robotics: The Plan to Build a Massive Online Brain for All the World’s Robots

Cloud Robotics: The Plan to Build a Massive Online Brain for All the World’s Robots | Amazing Science | Scoop.it

If you walk into the computer science building at Stanford University, Mobi is standing in the lobby, encased in glass. He looks a bit like a garbage can, with a rod for a neck and a camera for eyes. He was one of several robots developed at Stanford in the 1980s to study how machines might learn to navigate their environment—a stepping stone toward intelligent robots that could live and work alongside humans. He worked, but not especially well. The best he could do was follow a path along a wall. Like so many other robots, his “brain” was on the small side.


Now, just down the hall from Mobi, scientists led by roboticist Ashutosh Saxena are taking this mission several steps further. They’re working to build machines that can see, hear, comprehend natural language (both written and spoken), and develop an understanding of the world around them, in much the same way that people do.


Today, backed by funding from the National Science Foundation, the Office of Naval Research, Google, Microsoft, and Qualcomm, Saxena and his team unveiled what they call RoboBrain, a kind of online service packed with information and artificial intelligence software that any robot could tap into. Working alongside researchers at the University of California at Berkeley, Brown University, and Cornell University, they hope to create a massive online “brain” that can help all robots navigate and even understand the world around them. “The purpose,” says Saxena, who dreamed it all up, “is to build a very good knowledge graph—or a knowledge base—for robots to use.”


Any researcher anywhere will be able use the service wirelessly, for free, and transplant its knowledge to local robots. These robots, in turn, will feed what they learn back into the service, improving RoboBrain’s know-how. Then the cycle repeats.


These days, if you want a robot to serve coffee or carry packages across a room, you have to hand-code a new software program—or ask a fellow roboticist to share code that’s already been built. If you want to teach a robot a new task, you start all over. These programs, or apps, live on the robot itself, and that, Saxena says, is inefficient. It goes against all the current trends in tech and artificial intelligence, which seek to exploit the power of distributed systems, massive clusters of computers that can power devices over the net. But this is starting to change. RoboBrain is part of an emerging movement known as cloud robotics.


Via Mariaschnee
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Tekrighter's curator insight, August 28, 10:01 AM

One of the most perplexing problems in science today is efficient integration of disparate data repositories. This is a step in the right direction.

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Modified yeast produces a range of opiates for the first time

Modified yeast produces a range of opiates for the first time | Amazing Science | Scoop.it

Yeast that can make opiates from other molecules raise the prospect of tanks of drug-producing microorganisms replacing open fields of opium poppies.


Severe pain? Reach for the yeast. Genetically engineered yeasts can now efficiently produce a range of opiates, including morphine and oxycodone. With growing anxieties about supplies of opium poppies, it could be just what the doctor ordered.


Opiates are primarily used as painkillers and cough suppressants, and many of the most widely used opiates can be produced only from opium poppies (Papaver somniferum). Demand for these drugs is booming. But of the poppies farmed to supply these drugs, some 50 per cent are grown on the Australian island of Tasmania, so poor growing seasons can affect availability.


As drug companies search for new places to grow poppiesChristina Smolkefrom Stanford University, California, and her colleagues have been looking at getting yeast to make these complex drugs from simple sugars.


Some opiates, like morphine, are made naturally by poppies. Others, like oxycodone, are produced by chemically altering one of the plant's natural alkaloid chemicals – in this case thebaine. Back in 2008, Smolke inserted a number of genes – including some from the opium poppy – into yeasts, and got them to turn simple sugar molecules into a complex precursor of opiates: salutaridine. Now, in her latest work, she has solved the other end of the pathway, engineering yeasts to take complex precursors like thebaine and synthesise the finished products, including oxycodone.


"This work gets us very close," says Smolke. All that's left is to combine the two stages in one strain of yeast, and solve the last few steps: getting the yeast to turn salutaridine into thebaine, completing the pathway from sugar to opiate product.


The benefits of yeast over poppies are manifold, Smolke says. She thinks that when the system is finished, a 1000-litre tank could produce as much morphine as a hectare of poppies. She believes the method, when completed, will also increase security. "It is difficult or impossible to secure many thousands of acres of poppy fields which are grown out in the open," she says. "Yeast will be grown in closed fermenters and can be kept in secure facilities."

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How the Computer of the Future Keeps Itself Cool

How the Computer of the Future Keeps Itself Cool | Amazing Science | Scoop.it
A team of theoretical physicists at the University of Hamburg, Germany have just published the schematics for a method that tackles the biggest hurdle in quantum computing: keeping everything cool.


One of the biggest issues facing the development of quantum computers—tomorrow's supercomputers based on the strange principles of quantum physics—is keeping everything cool. Electronics make heat, and while your laptop and smartphone can use fans or heat-absorbing water tanks, those just won't cut it for quantum computing, which will take advantage of the quirks of quantum mechanics to create computers that calculate at insane speeds. 

"When you start to make electronics smaller and denser, not only are you making much more heat in the same amount of volume, but it's much harder for the heat to flow outward," says Peter Nalbach, a theoretical physicist at the University of Hamburg, Germany. 

At this stage, our early attempts at quantum computers have to be kept at a temperature barely hovering above the insanely cold, dead-standstill of absolute zero. If you're trying to develop a large-scale quantum computer, Nalbach, says, "at a certain point, you'll have to actively transport heat out of the spot where it's created," Until now, engineers had no idea exactly how to do this. 

But Nalbach and his colleagues have just published the schematics of a method to individually target and cool the physical building blocks of tomorrow's quantum computers. In their outline, recently published in the physics journal Physical Review Letters, the physicists show how they can halve the temperature of individual quantum dots—nano-sized pieces of crystal that are currently being investigated as qubits for quantum computers

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CRISPR-CAS shows promising results for correcting muscular dystrophy in mice

CRISPR-CAS shows promising results for correcting muscular dystrophy in mice | Amazing Science | Scoop.it

Researchers used a technique called CRISPR/Cas9-mediated genome editing, which can precisely remove a mutation in DNA, allowing the body’s DNA repair mechanisms to replace it with a normal copy of the gene. The benefit of this over other gene therapy techniques is that it can permanently correct the “defect” in a gene rather than just transiently adding a “functional” one, said Dr. Eric Olson, Director of the Hamon Center for Regenerative Science and Medicine at UT Southwestern and Chairman ofMolecular Biology.


Using CRISPR/Cas9, the Hamon Center team was able to correct the genetic defect in the mouse model of DMD and prevent the development of features of the disease in boys, which causes progressive muscle weakness and degeneration, often along with breathing and heart complications.


“Our findings show that CRISPR/Cas9 can correct the genetic mutation that leads to DMD, at least in mice,” said Dr. Olson, holder of the Pogue Distinguished Chair in Research on Cardiac Birth Defects, the Robert A. Welch Distinguished Chair in Science, and the Annie and Willie Nelson Professorship in Stem Cell Research. “Even in mice with only a subset of corrected cells, we saw widespread and progressive improvement of the condition over time, likely reflecting an advantage of the corrected cells and their contribution to regenerating muscle.”


He also pointed out “this is very important for possible clinical application of this approach in the future. Skeletal muscle is the largest tissue in the human body and current gene therapy methods are only able to affect a portion of the muscle. If the corrected tissue can replace the diseased muscle, patients may get greater clinical benefit.”


Although the genetic cause of DMD has been known for nearly 30 years, there are no treatments that can cure the condition. Duchenne muscular dystrophy breaks down muscle fibers and replaces them with fibrous and/or fatty tissue causing the muscle to gradually weaken.


DMD affects an estimated 1 in 3,600–6,000 male births in the United States, according to the Centers for Disease Control (CDC). Left untreated, those with DMD eventually require use of a wheelchair between age 8 and 11, and have a life expectancy of 25 years. Initial symptoms include difficulty running and jumping, and delays in speech development. DMD can be detected through high levels of a protein called creatine kinase as it leaks into the blood stream, and is confirmed by genetic testing.

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Herpes simplex virus type 1 and Alzheimer’s disease: Increasing evidence for a major role of the virus

Herpes simplex virus type 1 and Alzheimer’s disease: Increasing evidence for a major role of the virus | Amazing Science | Scoop.it

The concept of a viral role in Alzheimer’s disease (AD), specifically of herpes simplex virus type 1 (HSV1), was first proposed several decades ago (Ball, 1982Gannicliffe et al., 1986). Legitimizing the concept clearly depended on a positive answer to a number of test questions, the first of which was whether or not HSV1 is ever present in human brain. The subsequent discovery that HSV1 DNA resides in a high proportion of brains of elderly people in latent form (Jamieson et al., 1991)—both normals and AD patients—immediately made the concept more credible, but raised associated questions such as whether or not the virus is ever active in brain or is merely a passive resident there; whether on its own it is a causative factor in AD or it acts thus only with another factor, perhaps genetic; if active, what causes its activity; whether there is any link with the characteristic abnormal features of AD brains or their components, and whether, if indeed implicated in AD, antiviral agents would be useful for treating the disease. These questions were posed in a previous review (Wozniak and Itzhaki, 2010)—and strong evidence was presented that permitted the answer to each question to be “yes” or, very likely to be “yes”. The present review briefly summarizes the earlier evidence, and provides an update, which is especially timely in view of the subsequent steady increase in number of relevant publications.


Herpes simplex virus type 1 (HSV1), when present in brain of carriers of the type 4 allele of the apolipoprotein E gene (APOE), has been implicated as a major factor in Alzheimer’s disease (AD). It is proposed that virus is normally latent in many elderly brains but reactivates periodically (as in the peripheral nervous system) under certain conditions, for example stress, immunosuppression, and peripheral infection, causing cumulative damage and eventually development of AD.


Diverse approaches have provided data that explicitly support, directly or indirectly, these concepts. Several have confirmed HSV1 DNA presence in human brains, and the HSV1-APOE-ε4 association in AD. Further, studies on HSV1-infected APOE-transgenic mice have shown that APOE-e4 animals display a greater potential for viral damage. Reactivated HSV1 can cause direct and inflammatory damage, probably involving increased formation of beta amyloid (Aβ) and of AD-like tau (P-tau)—changes found to occur in HSV1-infected cell cultures.


Implicating HSV1 further in AD is the discovery that HSV1 DNA is specifically localized in amyloid plaques in AD. Other relevant, harmful effects of infection include the following: dynamic interactions between HSV1 and amyloid precursor protein (APP), which would affect both viral and APP transport; induction of toll-like receptors (TLRs) in HSV1-infected astrocyte cultures, which has been linked to the likely effects of reactivation of the virus in brain.


Several epidemiological studies have now shown, using serological data, an association between systemic infections and cognitive decline, with HSV1 particularly implicated. Genetic studies too have linked various pathways in AD with those occurring on HSV1 infection. In relation to the potential usage of antivirals to treat AD patients, acyclovir (ACV) is effective in reducing HSV1-induced AD-like changes in cell cultures, and valacyclovir, the bioactive form of ACV, might be most effective if combined with an antiviral that acts by a different mechanism, such as intravenous immunoglobulin (IVIG).

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Krishan Maggon 's curator insight, September 2, 6:48 PM

Thanks Dr. Gruenwald.

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There are scenarios where chimpanzees are more intelligent than us: Chimps outplay humans in brain games

There are scenarios where chimpanzees are more intelligent than us: Chimps outplay humans in brain games | Amazing Science | Scoop.it

We humans assume we are the smartest of all creations. In a world with over 8.7 million species, only we have the ability to understand the inner workings of our body while also unraveling the mysteries of the universe. We are the geniuses, the philosophers, the artists, the poets and savants. We amuse at a dog playing ball, a dolphin jumping rings, or a monkey imitating man because we think of these as remarkable acts for animals that, we presume, aren’t smart as us. But what issmart? Is it just about having ideas, or being good at language and math?


In a recent study by psychologists Colin Camerer and Tetsuro Matsuzawa, chimps and humans played a strategy game – and unexpectedly, the chimps outplayed the humans.


Chimps are a scientist’s favorite model to understand human brain and behavior. Chimp and human DNAs overlap by a whopping 99 percent, which makes us closer to chimps than horses to zebras. Yet at some point, we evolved differently. Our behavior and personalities, molded to some extent by our distinct societies, are strikingly different from that of our fellow primates. Chimps are aggressive and status-hungry within their hierarchical societies, knit around a dominant alpha male. We are, perhaps, a little less so. So the question arises whether competitive behavior is hard-wired in them.


In the present study, chimp pairs or human pairs contested in a two-player video game. Each player simply had to choose between left and right squares on a touch-screen panel, while being blind to their rival’s choice. Player A, for instance, won, each time their choices matched, and player B won, if their choices did not. The opponent’s choice was displayed after every selection, and payoffs in the form of apple cubes or money were dispensed to the winner.


In Camerer’s experiment, it turned out that chimps played a near-ideal game, as their choices leaned closer to game theory equilibrium. Whereas, when humans played, their choices drifted farther off from theoretical predictions. Since the game is a test of how much the players recall of their opponent’s choice history, and how cleverly they maneuver by following choice patterns, the results suggest that chimps may have a superior memory and strategy, which help them perform better in a competition, than humans. In other words, chimps seem to have some sort of a knack when fighting peers in a face-off. 


Their exceptional working memory may be a key factor for chimps’ strategic skills. A movie clip, part of a study in 2007, impressively captures the eidetic memory of a 2-year old chimp as he played a memory masking game.  It makes jaws drop to see him memorize random numerical patterns within 200 milliseconds, about half the time it takes for the human eye to blink. Memory of such incredible precision is rare in human babies and close to absent in adults, save for fictitious characters like Sheldon Cooper.


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New satellite maps show polar ice caps melting at 'unprecedented rate'

New satellite maps show polar ice caps melting at 'unprecedented rate' | Amazing Science | Scoop.it

Climate News Network: Scientists reveal Greenland and Antarctica losing 500 cubic kms of ice annually.


German researchers have established the height of the Greenland and Antarctic ice caps with greater precision than ever before. The new maps they have produced show that the ice is melting at an unprecedented rate.


The maps, produced with a satellite-mounted instrument, have elevation accuracies to within a few meters. Since Greenland’s ice cap is more than 2,000 meters thick on average, and the Antarctic bedrock supports 61% of the planet’s fresh water, this means that scientists can make more accurate assessments of annual melting.


Dr Veit Helm and other glaciologists at the Alfred Wegener Institute’sHelmholtz Centre for Polar and Marine Research in Bremerhaven, Germany, report in the journal The Cryosphere that, between them, the two ice sheets are now losing ice at the unprecedented rate of 500 cubic kilometres a year.


The measurements used to make the maps were taken by an instrument aboard the European Space Agency’s orbiting satelliteCryoSat-2. The satellite gets closer to the poles − to 88° latitude − than any previous mission and traverses almost 16m sq km of ice, adding an area of ice the size of Spain to the big picture of change and loss in the frozen world.


CryoSat-2’s radar altimeter transmitted 7.5m measurements of Greenland and 61m of Antarctica during 2012, enabling glaciologists to work with a set of consistent measurements from a single instrument.


Over a three-year period, the researchers collected 200m measurements in Antarctica and more than 14m in Greenland. They were able to study how the ice sheets changed by comparing the data with measurements made by Nasa’s IceSat mission.


Greenland’s volume of ice is being reduced at the rate of 375 cubic km a year. In Antarctica, the picture is more complex as the West Antarctic ice sheet is losing ice rapidly, but is growing in volume in East Antarctica.

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Schrödinger's cat caught on quantum film using quantum entanglement

Schrödinger's cat caught on quantum film using quantum entanglement | Amazing Science | Scoop.it

The patron animal of quantum theory poses for a unique portrait in which the camera and the sitter don't share a single photon – except by entanglement.


Information is central to quantum mechanics. In particular, quantum interference occurs only if there exists no information to distinguish between the superposed states. The mere possibility of obtaining information that could distinguish between overlapping states inhibits quantum interference12. Gabriela Barreto Lemos at the Austrian Academy of Sciences introduces and experimentally demonstrates a quantum imaging concept based on induced coherence without induced emission34. The experiment uses two separate down-conversion nonlinear crystals (numbered NL1 and NL2), each illuminated by the same pump laser, creating one pair of photons (denoted idler and signal). If the photon pair is created in NL1, one photon (the idler) passes through the object to be imaged and is overlapped with the idler amplitude created in NL2, its source thus being undefined.


Interference of the signal amplitudes coming from the two crystals then reveals the image of the object. The photons that pass through the imaged object (idler photons from NL1) are never detected, while we obtain images exclusively with the signal photons (from NL1 and NL2), which do not interact with the object.


The experiment is fundamentally different from previous quantum imaging techniques, such as interaction-free imaging5 or ghost imaging6789, because now the photons used to illuminate the object do not have to be detected at all and no coincidence detection is necessary. This enables the probe wavelength to be chosen in a range for which suitable detectors are not available. To illustrate this, the researchers show images of objects that are either opaque or invisible to the detected photons. This experiment is a prototype in quantum information—knowledge can be extracted by, and about, a photon that is never detected.

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Donald Schwartz's curator insight, August 30, 2:34 PM

 

As I live and breath, are there no mysteries any more?

 

 

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Eczema Fungus Found Everywhere Including Deep Hydrothermal Vents And Antarctic Soil

Eczema Fungus Found Everywhere Including Deep Hydrothermal Vents And Antarctic Soil | Amazing Science | Scoop.it

Professor Anthony Amend from the University of Hawaii at Manoa showed very recently that the fungus genus Malassezia is not only found on human skin with conditions such as dandruff and eczema, but has also been identified in marine environments such as deep-sea sediment, hydrothermal vents, corals, guts of lobster larvae, eel tissue, and Antarctica soils.


More remarkably, sequencing and tree building of species relatedness shows that the marine species and terrestrial (non-marine) species do not group together but “interdigitate”, or are spread randomly in the way they group together in their relatedness.  The evidence suggests that the marine and terrestrial forms have jumped repeatedly between habitats.


The data was obtained from a number of sources, most of them “environmental sequencing” projects around the world which aim to do simultaneous sequencing of all DNA found in a sample.  Done correctly the analysis yields in one try the identities of all organisms captured in a sample.


Prior to this analysis, it was thought that these fungus evolved to become optimally suited to mammalian skin.  But the careful analysis of environmental sequencing efforts overturned that belief.  One species could be spread out all over the globe, on land as well as in ocean.  One example is Malassezia restricta, found on human skin but also in extreme habitats such as arctic soil and hydrothermal vents. Marine animals also carry this fungus, including higher order seals and lower order fish, lobsters, and corals.


One criticism is that sequencing is bound to become contaminated especially with a fungus endemic to human skin.  However, the detection of completely novel species cannot be explained by contamination.  And moreover, RNA is a fairly unstable molecule, so in the cases where detection occurred for some of the samples in which there was sufficient time for degradation suggests that microbes were actively generating RNA.


While it is associated with many skin conditions it is unclear as of yet whether the fungus is a causal factor.  This is simply because disease etiology is a complex interplay of an individual immune system and disease agent.

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Mystery solved: 'Sailing stones' of death valley seen in action for the first time

Mystery solved: 'Sailing stones' of death valley seen in action for the first time | Amazing Science | Scoop.it

Racetrack Playa is home to an enduring Death Valley mystery. Littered across the surface of this dry lake, also called a "playa," are hundreds of rocks – some weighing as much as 320 kilograms (700 pounds) – that seem to have been dragged across the ground, leaving synchronized trails that can stretch for hundreds of meters.

What powerful force could be moving them? Researchers have investigated this question since the 1940s, but no one has seen the process in action – until now. In a paper published in the journal PLOS ONE on Aug. 27, a team led by Scripps Institution of Oceanography, UC San Diego, paleobiologist Richard Norris reports on first-hand observations of the phenomenon.


Because the stones can sit for a decade or more without moving, the researchers did not originally expect to see motion in person. Instead, they decided to monitor the rocks remotely by installing a high-resolution weather station capable of measuring gusts to one-second intervals and fitting 15 rocks with custom-built, motion-activated GPS units. The National Park Service would not let them use native rocks, so they brought in similar rocks from an outside source.


The experiment was set up in winter 2011 with permission of the Park Service. Then – in what Ralph Lorenz of the Applied Physics Laboratory at the Johns Hopkins University, one of the paper's authors, suspected would be  "the most boring experiment ever" – they waited for something to happen.


But in December 2013, Norris and co-author and cousin Jim Norris arrived in Death Valley to discover that the playa was covered with a pond of water seven centimeters (three inches) deep. Shortly after, the rocks began moving.


"Science sometimes has an element of luck," Richard Norris said. "We expected to wait five or ten years without anything moving, but only two years into the project, we just happened to be there at the right time to see it happen in person."


Their observations show that moving the rocks requires a rare combination of events. First, the playa fills with water, which must be deep enough to form floating ice during cold winter nights but shallow enough to expose the rocks. As nighttime temperatures plummet, the pond freezes to form thin sheets of "windowpane" ice, which must be thin enough to move freely but thick enough to maintain strength. On sunny days, the ice begins to melt and break up into large floating panels, which light winds drive across the playa, pushing rocks in front of them and leaving trails in the soft mud below the surface.


"On Dec. 21, 2013, ice breakup happened just around noon, with popping and cracking sounds coming from all over the frozen pond surface," said Richard Norris. "I said to Jim, 'This is it!'"


The video in this article nicely explains how the non-aerodynamic rocks of Death Valley's Racetrack Playa move, leaving behind their trail in the hot desert.  Numerous attempts using GPS receivers and old-fashioned observations.  But observing ice in Death Valley is so rare that no one had ever seen it until now.  On very rare occasions, when it rains in the region, water will accumulate in the playa.  If the wind is powerful and consistent enough, the wind will push the panels of ice against these rocks and over time, the ice floes will push these rocks, leaving behind distinctive trails. This perfect combination of water, wind, ice and heat creates a remarkable signature on the landscape.

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Seagate Ships World’s First 8TB Hard Drives

Seagate Ships World’s First 8TB Hard Drives | Amazing Science | Scoop.it

Seagate Technology (NASDAQ:STX), a world leader in storage solutions, today announced it is shipping the world’s first 8TB hard disk drive. An important step forward in storage, the 8TB hard disk drive provides scale-out data infrastructures with supersized-capacity, energy-efficiency and the lowest total cost of ownership (TCO) in the industry for cloud content, object storage and back-up disaster recovery storage.


“As our world becomes more mobile, the number of devices we use to create and consume data is driving an explosive growth in unstructured data. This places increased pressure on cloud builders to look for innovative ways to build cost-effective, high capacity storage for both private and cloud-based data centers,” said Scott Horn, Seagate vice president of marketing. “Seagate is poised to address this challenge by offering the world’s first 8TB HDD, a ground-breaking new solution for meeting the increased capacities needed to support the demand for high capacity storage in a world bursting with digital creation, consumption and long-term storage.”


A cornerstone for growing capacities in multiple applications, the 8TB hard drive delivers bulk data storage solutions for online content storage providing customers with the highest capacity density needed to address an ever increasing amount of unstructured data in an industry-standard 3.5-inch HDD. Providing up to 8TB in a single drive slot, the drive delivers maximum rack density, within an existing footprint, for the most efficient data center floor space usage possible.


“Public and private data centers are grappling with efficiently storing massive amounts of unstructured digital content,” said John Rydning, IDC’s research vice president for hard disk drives. “Seagate’s new 8TB HDD provides IT managers with a new option for improving storage density in the data center, thus helping them to tackle one of the largest and fastest growing data categories within enterprise storage economically.”


The 8TB hard disk drive increases system capacity using fewer components for increased system and staffing efficiencies while lowering power costs. With its low operating power consumption, the drive reliably conserves energy thereby reducing overall operating costs. Helping customers economically store data, it boasts the best Watts/GB for enterprise bulk data storage in the industry.


“Cleversafe is excited to once again partner with Seagate to deliver to our customers what is truly an innovative storage solution. Delivering absolute lowest cost/TB along with the performance and reliability required for massive scale applications, the new 8TB hard disk drive is ideal for meeting the needs of our enterprise and service provider customers who demand optimized hardware and the cost structure needed for massive scale out,” said Tom Shirley, senior vice president of research and development, Cleversafe.


Outfitted with enterprise-class reliability and support for archive workloads, it features multi-drive RV tolerance for consistent enterprise-class performance in high density environments. The drive also incorporates a proven SATA 6Gb/s interface for cost-effective, easy system integration in both private and public data centers.

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Russ Roberts's curator insight, August 28, 1:53 AM

This is a real game changer when it comes to bulk data storage.  According to a Seagate press release, "the 8TB hard disc drive increases system  capacity using fewer components for increased system and staffing efficiencies while lowering power costs...it boasts the best Watt/GB for enterprise bulk data storage in the industry."  Drives of this magnitude will become commonplace as the demand for digital storage grows.  There may be an amateur radio application here, especially for those into SDR (software defined radios), exotic digital modes, and contesting.  Aloha de Russ (KH6JRM).

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NASA: 101 Counted Geysers on Icy Saturn Moon Enceladus

NASA: 101 Counted Geysers on Icy Saturn Moon Enceladus | Amazing Science | Scoop.it
Scientists using mission data from NASA’s Cassini spacecraft have identified 101 distinct geysers erupting on Saturn’s icy moon Enceladus. Their analysis suggests it is possible for liquid water to reach from the moon’s underground sea all the way to its surface.


Over a period of almost seven years, Cassini’s cameras surveyed the south polar terrain of the small moon, a unique geological basin renowned for its four prominent "tiger stripe” fractures and the geysers of tiny icy particles and water vapor first sighted there nearly 10 years ago. The result of the survey is a map of 101 geysers, each erupting from one of the tiger stripe fractures, and the discovery that individual geysers are coincident with small hot spots. These relationships pointed the way to the geysers’ origin.


After the first sighting of the geysers in 2005, scientists suspected repeated flexing of Enceladus by Saturn’s tides as the moon orbits the planet had something to do with their behavior. One suggestion included the back-and-forth rubbing of opposing walls of the fractures generating frictional heat that turned ice into geyser-forming vapor and liquid.


Alternate views held that the opening and closing of the fractures allowed water vapor from below to reach the surface. Before this new study, it was not clear which process was the dominating influence. Nor was it certain whether excess heat emitted by Enceladus was everywhere correlated with geyser activity.


To determine the surface locations of the geysers, researchers employed the same process of triangulation used historically to survey geological features on Earth, such as mountains. When the researchers compared the geysers’ locations with low-resolution maps of thermal emission, it became apparent the greatest geyser activity coincided with the greatest thermal radiation. Comparisons between the geysers and tidal stresses revealed similar connections. However, these correlations alone were insufficient to answer the question, “What produces what?”


The answer to this mystery came from comparison of the survey results with high-resolution data collected in 2010 by Cassini’s heat-sensing instruments. Individual geysers were found to coincide with small-scale hot spots, only a few dozen feet (or tens of meters) across, which were too small to be produced by frictional heating, but the right size to be the result of condensation of vapor on the near-surface walls of the fractures. This immediately implicated the hot spots as the signature of the geysering process.


“Once we had these results in hand we knew right away heat was not causing the geysers, but vice versa,” said Carolyn Porco, leader of the Cassini imaging team from the Space Science Institute in Boulder, Colorado, and lead author of the first paper. “It also told us the geysers are not a near-surface phenomenon, but have much deeper roots.”


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First satellite with high-resolution public imaging launched on August 13th, 2014

First satellite with high-resolution public imaging launched on August 13th, 2014 | Amazing Science | Scoop.it

WorldView-3, the world’s first multi-payload, super-spectral, high-resolution commercial satellite for earth observations and advanced geospatial solutions, launched into orbit on Aug. 13 aboard an Atlas rocket. Operating at an expected altitude of 617 km, WorldView-3 will have an average revisit time of less than one day and will be capable of collecting up to 680,000 square kilometers of imagery per day. Its data-rich imagery will discover new sources of minerals and fuels, manage forests and farms, and accelerate DigitalGlobe’s exploitation of Geospatial Big Data™ – a living digital inventory of the surface of the Earth.


The data should lead to much nicer imagery in online mapping services from companies like Google and Microsoft (both of which are DigitalGlobe customers), although it's not just cosmetic. Higher-res photos will help track large farms, spot mineral deposits and otherwise deliver a clearer view of our planet that has previously been limited to the government -- don't be surprised if it's easier to spot landmarks on a map without using markers.

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Google's fact-checking bots are automatically building the Knowledge Vault for access to the world's facts

Google's fact-checking bots are automatically building the Knowledge Vault for access to the world's facts | Amazing Science | Scoop.it

The search giant is automatically building Knowledge Vault, a massive database that could give us unprecedented access to the world's facts

GOOGLE is building the largest store of knowledge in human history – and it's doing so without any human help.


Instead, Knowledge Vault autonomously gathers and merges information from across the web into a single base of facts about the world, and the people and objects in it.


The breadth and accuracy of this gathered knowledge is already becoming the foundation of systems that allow robots and smartphones to understand what people ask them. It promises to let Google answer questions like an oracle rather than a search engine, and even to turn a new lens on human history.


Knowledge Vault is a type of "knowledge base" – a system that stores information so that machines as well as people can read it. Where a database deals with numbers, a knowledge base deals with facts. When you type "Where was Madonna born" into Google, for example, the place given is pulled from Google's existing knowledge base.


This existing base, called Knowledge Graph, relies on crowdsourcing to expand its information. But the firm noticed that growth was stalling; humans could only take it so far.


So Google decided it needed to automate the process. It started building the Vault by using an algorithm to automatically pull in information from all over the web, using machine learning to turn the raw data into usable pieces of knowledge.


Knowledge Vault has pulled in 1.6 billion facts to date. Of these, 271 million are rated as "confident facts", to which Google's model ascribes a more than 90 per cent chance of being true. It does this by cross-referencing new facts with what it already knows.


"It's a hugely impressive thing that they are pulling off," says Fabian Suchanek, a data scientist at Télécom ParisTech in France. Google's Knowledge Graph is currently bigger than the Knowledge Vault, but it only includes manually integrated sources such as the CIA Factbook.


Knowledge Vault offers Google fast, automatic expansion of its knowledge – and it's only going to get bigger. As well as the ability to analyse text on a webpage for facts to feed its knowledge base, Google can also peer under the surface of the web, hunting for hidden sources of data such as the figures that feed Amazon product pages, for example.


Tom Austin, a technology analyst at Gartner in Boston, says that the world's biggest technology companies are racing to build similar vaults. "Google, Microsoft, Facebook, Amazon and IBM are all building them, and they're tackling these enormous problems that we would never even have thought of trying 10 years ago," he says.

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Imprint of Primordial Monster Star Found

Imprint of Primordial Monster Star Found | Amazing Science | Scoop.it

The very first stars in the Universe might have been hundreds of times more massive than the Sun.


Astronomers have found evidence for the existence of the monster stars long thought to have populated the early Universe. Weighing in at hundreds of times the mass of the Sun, such stars would have been the first to fuse primordial hydrogen and helium into heavier elements, leaving behind a chemical signature that the researchers have now found in an ancient, second-generation star.


Little is known about the Universe’s first stars, which would have formed out of clouds of hydrogen, helium and a tiny amount of lithium in the first few hundred million years after the Big Bang.


Simulations have long predicted that some of this first batch of stars were enormous. With masses of more than 100 times that of the Sun, they would have lived and died in the cosmic blink of an eye, a few million years. As they exploded in supernovae, they created the first heavy elements from which later galaxies and stars evolved. But no traces of their existence have previously been found.


Now, using a technique called stellar archaeology, Wako Aoki at the National Astronomical Observatory of Japan in Tokyo and his colleagues have found the first hint of such a star, preserved in the chemical make-up of its ancient daughter. The chemistry of this relic — a star called SDSS J0018-0939 — suggests that it may have formed from a cloud of gas seeded with material created in the explosion of a single, very massive star. The results were published in Science on 21 August.


“This is a much awaited discovery,” says Naoki Yoshida, an astrophysicist at the University of Tokyo who was not involved in the study. That such chemical signatures have never been found in the Universe, despite many theoretical studies predicting their existence, is a long-standing puzzle, he says. “It seems Aoki et al. have finally found an old relic that shows intriguing evidence that there really was such a monstrous star in the distant past.”

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Scientists have built a simple model of viruses’ protective coats in an attempt to create viral mimics

Scientists have built a simple model of viruses’ protective coats in an attempt to create viral mimics | Amazing Science | Scoop.it

An artificial protein that self-assembles around and protects DNA could be ideal for gene therapy, nanomachines and synthetic biology.


Dutch scientists have built a simple model of viruses’ protective coats in an attempt to create viral mimics that could fight diseases, as opposed to causing them. Rather than copying natural proteins, Renko de Vries from Wageningen University and his team designed and built a three-part protein from scratch that self-assembles around DNA.


‘The protein is exceedingly simple in its primary and secondary structure, yet captures the essence of self-assembly for the tobacco mosaic virus,’ de Vries tells Chemistry World. This knowledge could enable superior vehicles for getting DNA and RNA into cells, for example for gene therapy, and templates for improved DNA machines. ‘You could probably do the same with supramolecular chemistry,’ de Vries adds, ‘but the protein approach has the beauty that you can expand in the direction of synthetic biology.’


The ‘no-frills’ coat sprung from de Vries’ discussions with Paul van der Schoot’s Technical University of Eindhoven team, who had developed a theoretical model of tobacco mosaic virus self-assembly. ‘We established the crucial mechanisms and then started designing these molecules,’ de Vries explains.


The protein’s first segment, which bound to the DNA to be encapsulated, simply comprised 12 lysine amino acid building blocks. The second was a ‘silk-like’ protein sequence, containing repeat units of mostly alanine and glycine amino acids, that can form stiff filaments. Varying the number of repeat silk-like units allowed the chemists to dictate cooperation between segments during coat assembly. The third segment was a random 400 residue sequence with many prolines and other hydrophilic, uncharged amino acids that stopped the rod-shaped ‘virus-like particles’ (VLPs) clumping together.


‘We found that the self-assembly was really quite spectacular,’ de Vries recalls. ‘If you have one protein sticking to the nucleic acid template, that accelerates binding of further proteins. That ensures that you always have at least a couple of templates perfectly coated, even if you do not have enough protein. For the 2500 base pair linear DNA we used, about 400 copies of the artificial virus protein are needed to make the complete coat.’


Out of five different silk-like segment lengths the team tried, only the two longest ones led to fully cooperative coat self-assembly. These VLPs compacted their central DNA most and protected it from enzyme attack for longer. However, all of the different silk-like segment lengths produced VLPs that could transfect DNA into cells with similar efficiency.

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