Hantavirus just jumped hosts. Four new forms of hantaviruses, a virus transmitted from animals to humans, suggest the pathogen may have originated in bats.
The existence of these newly described hantaviruses in bats and other insect-eating carnivores has challenged the conventional view that they originated in rodents. It also suggests there may be additional unrecognised hantaviruses circulating in a wide range of animal hosts, particularly bats, and that the hantaviruses frequently jump hosts.
“This breakthrough in understanding the biodiversity and evolution of hantaviruses could help arm us against the threat of a pandemic,” said Professor Eddie Holmes, an NHMRC Australia Fellow at the University of Sydney, based at the Sydney Emerging Infections and Biosecurity Institute.
“Hantavirus is a major threat to global health, making information that adds to our poor understanding of how it evolved and is transmitted an important contribution to fighting the disease.”
The new international research on hantavirus is published in PLOS Pathogens today, led by researchers at the China Centre for Disease Control and Prevention and contributed to by Professor Holmes.
Hantavirus causes influenza-like symptoms which can lead to respiratory and kidney failure in humans. It is a life-threatening emerging infection which usually appears as sporadic disease outbreaks such as that which occurred in 1993 in a region of the United States where New Mexico, Arizona, Colorado, and Utah share a border.
“Our research describes four novel hantaviruses, sampled from bats and shrews in China, which are distinct from known hantaviruses.”
“Despite the public health threat hantavirus poses there is no scientific consensus on their evolutionary history, especially how diverse they are or how often their transmission jumps species barriers.”