Oligodendroglia provide lactate to neurons via protein MCT1. The lactate is vital to the neuron's survival. MCT1 is found in only oligodendroglia in the brain. MCT1 is found to be reduces in ALS patients.
My questions: Do we know of MCT1 mutants in ALS patients? MCT1 seems to have no structure yet. Have the FoldIt guys tried getting a putative structure?
Need to explore this more. Thoughts/suggestions welcome