CCRES is constantly striving to manufacture products that can make a positive and meaningful contribution to people, society, and our future well-being. Leveraging our technical capabilities developed over the years, we plan to further harness our originality in the fields of bulk pharmaceuticals, pharmaceutical products, and the life sciences. We look forward to your continued patronage and support. CCRES ALGAE TEAM
Hepatitis C virus (HCV) infection is a significant public health problem with over 170,000,000 chronic carriers and infection rates increasing worldwide. Chronic HCV infection is one of the leading causes of hepatocellular carcinoma which was estimated to result in ~10,000 deaths in the United States in the year 2011. Current treatment options for HCV infection are limited to PEG-ylated interferon alpha (IFN-α), the nucleoside ribavirin and the recently approved HCV protease inhibitors telaprevir and boceprevir. Although showing significantly improved efficacy over the previous therapies, treatment with protease inhibitors has been shown to result in the rapid emergence of drug-resistant virus. Here we report the activity of two proteins, originally isolated from natural product extracts, which demonstrate low or sub-nanomolar in vitroactivity against both genotype I and genotype II HCV. These proteins inhibit viral infectivity, binding to the HCV envelope glycoproteins E1 and E2 and block viral entry into human hepatocytes. In addition, we demonstrate that the most potent of these agents, the protein griffithsin, is readily bioavailable after subcutaneous injection and shows significant in vivoefficacy in reducing HCV viral titers in a mouse model system with engrafted human hepatocytes. These results indicate that HCV viral entry inhibitors can be an effective component of anti-HCV therapy and that these proteins should be studied further for their therapeutic potential. http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0064449
Tucked away in darkness and almost dead, algae can emerge from a frigid and foggy environment to live again — and perhaps even become the seeds for a new beginning that can provide biofuel for a clean energy future.
“The ongoing support from the private investment community speaks to how strongly they believe in the development of Green Crude as an alternative fuel resource, especially ability to commercialize it,” says Branka Kalle, President of Council CCRES
At present, most #astaxanthin is chemically synthesized, costs up to US$7,500 per kilogram, and is only suitable for adding to animal feed, rather than for human consumption, but astaxanthin from the #microalgae Haematococcus pluvialis, the richest known natural source of astaxanthin has the potential to expand for large-scale production said Zeljko Serdar, project leader of #CCRES algae team.
Dietary supplements are often used to improve the nutritional status of people living with HIV/AIDS (PLHIV). Arthrospira platensis (Asp), also known as Spirulina, is a cyanobacterium rich in proteins and micronutrients. Cell and animal trials described immune-modulating, antiretroviral and antioxidant activities. This pilot study describes the effects of the supplementation of 5 g/day of Asp on a pre-highly-active antiretroviral therapy (pre-HAART), HIV-infected, adult female population. CCRES ALGAE TEAM
More videos at http://www.andalusianstories.com The Marine Microalgae Biotechnology Group of the University of Almería has developed a cultivation system tha...
The Marine Microalgae Biotechnology Group of the University of Almería has developed a cultivation system that permits increased production of dinoflagellates, a type of microalgae with therapeutical properties. The researchers say it is the first step for their future use in the pharmaceutical industry, as these microalgae have anticarcinogenic and analgesic properties that would be useful in the creation of new drugs. CCRES ALGAE TEAM
Microalgae-based biofuel not only has the potential to quench a sizable chunk of the world's energy demands, say Utah State University researchers. It's a potential game-changer.
"That's because microalgae produces much higher yields of fuel-producing biomass than other traditional fuel feedstocks and it doesn't compete with food crops," says USU mechanical engineering graduate student Jeff Moody.
With USU colleagues Chris McGinty and Jason Quinn, Moody published findings from an unprecedented worldwide microalgae productivity assessment in the May 26, 2014 Edition of the Proceedings of the National Academy of Sciences. The team's research was supported by the U.S. Department of Energy.
Despite its promise as a biofuel source, the USU investigators questioned whether "pond scum" could be a silver bullet-solution to challenges posed by fossil fuel dependence.
"Our aim wasn't to debunk existing literature, but to produce a more exhaustive, accurate and realistic assessment of the current global yield of microalgae biomass and lipids," Moody says.
With Quinn, assistant professor in USU's Department of Mechanical and Aerospace Engineering, and McGinty, associate director of USU's Remote Sensing/Geographic Information Systems Laboratory in the Department of Wildland Resources, Moody leveraged a large-scale, outdoor microalgae growth model. Using meteorological data from 4,388 global locations, the team determined the current global productivity potential of microalgae.
Algae, he says, yields about 2,500 gallons of biofuel per acre per year. In contrast, soybeans yield approximately 48 gallons; corn about 18 gallons.
"In addition, soybeans and corn require arable land that detracts from food production," Quinn says. "Microalgae can be produced in non-arable areas unsuitable for agriculture."
The researchers estimate untillable land in Brazil, Canada, China and the U.S. could be used to produce enough algal biofuel to supplement more than 30 percent of those countries' fuel consumption.
A team of researchers from Old Dominion University, in Norfolk, Virginia, United States, will soon pit their algae processing technology against engineers and scientists from across the U.S. in the P3 (People, Prosperity and the Planet) Competition sponsored by the Environmental Protection Agency.
Building upon its proprietary platform of high performance, sustainable Tailored™ algal-based oils, the company has introduced Encapso™, the world’s first encapsulated biodegradable lubricant for drilling fluids designed to deliver high-grade lubricant at the point of friction where and when needed.
At a recent hearing of the U.S. Armed Services Committee, Texas Republican Senator Ted Cruz grills Secretary of the Navy Raymond E. Mabus, Jr. on the reasons the Navy continues to support the use of algal biofuels at a time of budget cuts in military spending. CCRES ALGAE TEAM
CCRES microponds represent the leading Croatian research facility for the outdoor production of...
Astaxanthin - Factoids
One of the technical challenges to developing Haematococcus algae astaxanthin has been the tough cell wall of the spores, which must be ruptured to allow the cell contents to be effectively digested by animals. Cyanotech Corporation in Hawaii uses a combination of closed photobioreactors and open culture ponds to successfully mass produce astaxanthin-rich Haematococcus biomass, and proprietary milling technology to crack the cell walls. Commercial production of astaxanthin is being carried out in USA, India, Japan and Israel Astaxanthin is a carotenoid. Astaxanthin has been shown in studies to have 100-500 times the antioxidant capacity of Vitamin E as well as 10 times beta-carotene’s antioxidant capacity. Astaxanthin is found in many places in nature, but it is usually in small quantities as in salmon or shrimp. By far the most concentrated and natural source of astaxanthin is the Haematococcus pluvialis algae. These green algae also provide other important carotenoids such as beta-carotene. It accumulate the highest levels of astaxanthin in nature; commercially more than 40g of astaxanthin per kilo of dry biomass. Research shows that due to astaxanthin's potent antioxidant activity, it may be beneficial in cardiovascular, immune, inflammatory and neurodegenerative diseases. Some sources have demonstrated its potential as an anti-cancer agent. Research supports the assumption that it protects body tissues from oxidative damage. It also crosses the blood-brain barrier, which makes it available to the eye, brain and central nervous system to alleviate oxidative stress that contributes to ocular, and neurodegenerative diseases such as glaucoma and Alzheimer's. Astaxanthin, as other carotenoids, can act as a quencher of singlet oxygen and other free radicals by absorbing the excited energy of singlet oxygen onto the polyene electron-rich chain, resulting first in the excitation of the carotenoid to a triplet state, and then in the dissipation of the extra energy in the form of heat by relaxation back to the ground state. In this way, it prevents cellular components or tissues from being damaged. The carotenoid structure remains unchanged, and ready to act as a radical quencher. Astaxanthin has been shown to protect against free radicals and promote numerous health functions. Astaxanthin offers protection against a broad range of human diseases like neuro-degenerative disorders. The antioxidant of astaxanthin is stronger than β-carotene and vitamin E by 40x and 1,000x respectively.
CCRES ALGAE PROJECT part of Croatian Center of Renewable Energy Sources (CCRES)
An aerial view of the Muradel Demonstration Plant, Whyalla South Australia.
Renewable fuels company Muradel has launched Australia’s first integrated demonstration plant to sustainably convert algae into green crude, as a step towards a commercial plant with the potential to produce 80 million liters of crude oil a year. The $10.7 million demonstration plant at Whyalla – officially opened Oct. 31, 2014 – is intended to produce 30,000 liters of green crude a year, using Muradel’s Green2Black™ technology. #CCRES #ALGAE TEAM
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"CCRES is a member-based non-profit organization with membership open to research institutions, public and private sector organizations, students, and individuals." says Zeljko Serdar, President & CEO of CCRES.
Chlorella is a genus of single-celled green algae belonging to the phylum Chlorophyta. It is spherical, measuring between 2 and 10 μm in diameter. Chlorella contains chlorophyll in its chloroplast. Through photosynthesis it multiplies rapidly requiring only carbon dioxide, water, sunlight, and a small amount of minerals to reproduce.
It was once widely believed that Chlorella should serve as our main source of food and energy because of its highly efficient photosynthetic apparatus. When dried, it is about 45% protein, 20% fat, 20% carbohydrate, 5% fiber, and 10% vitamins and minerals. A Chlorella diet would supply all the essential amino acids. Thus it is a complete protein. However, later studies proved that Chlorella loses most of its nutritional value when altered or processed in any way.
Under certain growing conditions, Chlorella yields oils high in polyunsaturated fats -Chlorella minutissima has yielded EPA at 39.9% of total lipids.
Clinical studies on Chlorella suggest effects including: dioxin detoxification, healing from radiation exposure, reduction of high blood pressure, lower serum cholesterol levels, accelerated wound healing, and enhanced immune function. Chlorella has also been found to have anti-tumor properties when fed to mice. Another study found enhanced vascular function in hypertensive rats given oral doses of chlorella. In 1961 Melvin Calvin, a Nobel Prize laureate, used Chlorella for his research on the pathways of carbon dioxide assimilation. CCRES ALGAE TEAM
Bioenergy: America's Energy Future is a short documentary film showcasing examples of bioenergy innovations across the biomass supply chain and the United St...
In smaller countries, like Croatia, where oil demand is low, and emission standards are poor, algae biofuel has the potential to significantly reduce reliance on foreign oil. All the best! CCRES ALGAE TEAM
https://www.algenist.com - Biotechnology unlocking the Genius of Microalgae is at the foundation of Algenist's clinical skincare expertise delivering anti-ag...
Microalgae is at the foundation of Algenist’s clinical skincare expertise delivering anti-aging treatments to maintain youthful, beautiful skin. Solazyme’s 10 years of algal research has led to the discovery of two compounds – Alguronic Acid and Microalgae Oil – forming the basis of this product line. Today, Algenist is positioned to be a global leader in clinical skincare. Here’s the story. CCRES ALGAE TEAM
http://www.naturalhealth365.com issues an urgent health alert. Starting Jan. 2014 - a very dangerous form of synthetic astaxanthin will be flooding the marke...
Astaxanthin, a member of the carotenoid family, it is a dark red pigment and the main carotenoid found in algae and aquatic animals. It is responsible for the red/pink coloration of crustaceans, shellfish, and the flesh of salmonoids. CCRES produces astaxanthin from the microalga Haematococcus pluvialis, the richest known natural source for astaxanthin. Astaxanthin however, is more than just a red pigment, it is primarily an extremely powerful antioxidant. It has the unique capacity to quench free radicals and reactive species of oxygen and to inhibit lipid peroxidation. Studies have shown astaxanthin to be over 500 times stronger than vitamin E and much more potent than other carotenoids such as lutein, lycopene and β-carotene. Astaxanthin was found to have beneficial effects in many health conditions related to the Central Nervous System (CNS) disorders, skin health, joint health, muscle endurance, as well as to the cardiovascular, immune, eye and other systems. CCRES ALGAE TEAM
European scientists are experimenting with bacteria and algae and turn them into bioplastic factories. Their vision: these microorganisms should produce a la...
European scientists are experimenting with bacteria and algae to turn them into bioplastic factories. Their vision: these microorganisms should produce a large portion of our plastic materials without using any petroleum. CCRES ALGAE TEAM
Hong Kong scientists testing micro algae to clean water waste and produce fuel. The technology is still too expensive to be broadly developed, but researcher...
The technology is still too expensive to be broadly developed, but researchers are asking for the government’s support in protecting homegrown biofuel against cheaper, foreign competition. Rebecca Valli reports from Hong Kong for VOA Video. CCRES ALGAE TEAM