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Ageless Girl – Syndrome X - Scientists puzzled - Key To Eternal Youth?

Ageless Girl – Syndrome X - Scientists puzzled - Key To Eternal Youth? | AL_TU research | Scoop.it

Brooke Greenberg (born January 8, 1993), is a now 20 year old girl from Reisterstown, Maryland, who has remained physically and cognitively similar to a toddler. She is about 30 inches (76 cm) tall, weighs about 16 pounds (7.3 kg), and has an estimated mental age of 9 months to 1 year. Brooke’s doctors have termed her condition Syndrome X.

 

Brooke was born on January 8, 1993 at Sinai Hospital in Baltimore, Maryland, one month prior to her due date, weighing just four pounds (1.8 kg). She was born with anterior hip dislocation, a condition which caused her legs to be swiveled upwards, awkwardly, toward her shoulders; this was corrected surgically. Otherwise, Brooke appeared to be a normal infant.


In her first six years, Brooke Greenberg went through a series of unexplained medical emergencies from which she recovered. She had seven perforated stomach ulcers. She also suffered a seizure. This was followed by what was later diagnosed as a stroke; weeks later, no damage was detected. At age five, Brooke had a mass in her brain that caused her to sleep for 14 days. The doctors diagnosed the mass as a brain tumor. However, Brooke later awoke, and physicians found no tumor present. Brooke’s pediatrician, Dr. Lawrence Pakula, states that the source of her sudden illness remains a mystery.


Over the past several years, the Greenbergs visited many specialists, looking for an explanation for their daughter’s strange condition, and found she has a mutation in Chromosome 1. In 2001, when Dateline documented Brooke, she was still the size of a six-month-old infant, weighing just 13 lb (5.9 kg) at 27 inches (69 cm) tall. The family still had no explanation. Brooke Greenberg’s mother Melanie said: “They [the specialists] just said she’ll catch up. Then we went to the nutritionist, the endocrinologist. We tried the growth hormone…”. The growth hormone treatment had no effect. Howard, Brooke’s father, said: “I mean she did not put on an ounce or she did not grow an inch … That’s when I knew there was a problem.” After the growth hormone administration failed, the doctors, unable to diagnose a known condition, named her condition Syndrome X.


The Greenbergs made many visits to nearby Johns Hopkins Children’s Center, and even took Brooke to New York’s Mount Sinai Hospital, searching for information about their daughter’s condition. When geneticists sequenced Greenberg’s DNA, they found that the genes associated with the premature aging diseases were normal, unlike the mutated versions in patients with Werner syndrome and progeria.


In 2006, Dr. Richard Walker of the University of South Florida College of Medicine, said that Brooke’s body is not developing as a coordinated unit, but as independent parts that are out of sync. She has never been diagnosed with any known genetic disorder or chromosomal abnormality that would help explain why.


In 2009, Walker said: “There’ve been very minimal changes in Brooke’s brain … Various parts of her body, rather than all being at the same stage, seem to be disconnected.” Walker noted that Greenberg’s brain, for example, is not much more mature than that of a newborn infant. He estimates her mental age at around 9 months to a year old. Brooke can make gestures and recognize sounds, but cannot speak. Her bones are like those of a ten-year-old, and she still has her baby teeth, which have an estimated developmental age of about 8 years. Said Walker, “We think that Brooke’s condition presents us with a unique opportunity to understand the process of aging.”
Her telomeres seem to be shortening at the normal rate.

 

Yesterday, Brooke Greenberg and her family appeared on the Katie Courice Show as part of a show focused on medical mysteries. Greenberg, who is 20 years old, appears to be the age of a toddler. While the family does not know the root of Greenberg's apparent inability to age, Mount Sinai's Eric Schadt, who also appeared on the show with host Katie Couric, has been studying her genome. As Schadt notes in the clip below, in addition to figuring out the source of her disorder, Greenberg's genome could also help researchers learn more about the aging process.

 

Video Link: http://bcove.me/uesqzs6d


Via Dr. Stefan Gruenwald
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AL_TU: paraDOCs_DRY

AL_TU: paraDOCs_DRY | AL_TU research | Scoop.it
parametric, workshop, munich, muenchen, germany, fablab
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CLUSTER 1 - DON'T REPEAT YOURSELF - Munich, Germany

CAD vocabulary - basic and advanced modeling techniques and introduction to parametric design. 

 

This cluster will focus on general knowledge related to the topic of computational design. It will provide an introduction to how architectural tools emerged from different fields and how they keep on improving the discipline. It is a basic course which addresses people who need support in their parametric endeavors.

 

Participants will go through a series of assisted tutorials regarding nurbs modeling techniques in order to better appreciate the second part of the cluster regarding the automation of design processes. 

 

For more details follow:

https://www.facebook.com/ALTU.cdrl

http://all-2.blogspot.co.uk/2014/06/paradocsdry.html

 

FacebookEvent:

https://www.facebook.com/events/309436859222382/

 

Registration Form:

https://docs.google.com/forms/d/1ROkWZwa64H88eO8Uhso7cfs9ib4p-LEqtnAbQRgtXFQ/viewform

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AL_TU: P3 PAVILION

AL_TU: P3 PAVILION | AL_TU research | Scoop.it
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This pavilion—flexible enough to host numerous KAT events—would be an expression of both applied physical forces and imposed design decisions acting as shape defining criteria. The final design is based on a formal concept—defined by the usage of natural forces in order to generate catenary arches, a structural concept—which is a result of the superimposition of origami logic in order to define load bearing structural elements, and an intelligent connection concept—which rely on no binder and allow the repeated assembly and disassembly of the structure. For such a complex task to be grasped at once, the process had to be split in two distinctive parts: the form finding script and the connection and perforation script.


For more details:

http://all-2.blogspot.co.uk/2014/04/p3-pavilion.html

https://www.facebook.com/ALTU.cdrl

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RoboFab Winter 2014

RoboFab Winter 2014 | AL_TU research | Scoop.it

Via Ionut Anton
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Ionut Anton's curator insight, January 25, 2:28 AM

Robotic fab tutorial

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Digital Forming

Digital Forming | AL_TU research | Scoop.it

publish your 3d printing designs with intelectual property protection


Via Ionut Anton
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You Won't Believe These Patterns Created by Flocks of Birds in Flight

You Won't Believe These Patterns Created by Flocks of Birds in Flight | AL_TU research | Scoop.it
When birds travel in flocks, their behavior takes on emergent properties. Out of the chaos of flight, gorgeous, geometric patterns coalesce.
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Building Tensile Structures with Flying Machines

Building Tensile Structures with Flying Machines | AL_TU research | Scoop.it
Building tensile structures with flying machines in the ETH Zurich Flying Machine Arena. The video shows quadrocopters assembling prototypical tensile struct...

Via Alessio Erioli
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Ferroux

*UPDATE New video is up. Check out Ferienne: https://vimeo.com/42692741 _______________________ Second installation of my ongoing series focused on analog…

Via Alessio Erioli
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P3 Pavilion | Facebook

P3 Pavilion | Facebook | AL_TU research | Scoop.it
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P3 workshop movie

Vimeo is the home for high-quality videos and the people who love them.
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Amazing video about the P3 Workshops and its result! A must watch!

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Modeling complex systems with adaptive networks

Modeling complex systems with adaptive networks | AL_TU research | Scoop.it

Via amleto picerno
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Richard Platt's curator insight, October 20, 2013 9:29 AM

More tools for analyzing complex systems to find contradicitons, mmmm problems being solved 

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Beyond Performance

Beyond Performance | AL_TU research | Scoop.it
Beyond Performance architecture & interaction design
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Pawilon P^3 na Politechnice Łódzkiej, 2013.10.18

Projekt powstał w trakcie warsztatów zorganizowanych przez Koło Naukowe Studentów Architektury KĄT prowadzonych przez tutorów z Dessau. Otwarcie pawilonu prz...
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A walkthrough and few explanations regarding the P3 Workshops and P3 Pavilion project (polish version)

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Doctoral Thesis, online – runberger.net

Doctoral Thesis, online – runberger.net | AL_TU research | Scoop.it

Via Ionut Anton
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Ionut Anton's curator insight, October 14, 2013 11:17 AM

A very well written PhD thesis on the parametric design with excelent examples from great student projects.

Rescooped by Tudor Cosmatu from digital design
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SlideRule Searches for the Best Online Courses in Any Category

SlideRule Searches for the Best Online Courses in Any Category | AL_TU research | Scoop.it
Online classes are a great way to learn new skills. SlideRule makes your search easier by letting you browse and search through over 17,000 online courses.

Via Alessio Erioli, Irina Bogdan
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Free eBook - How Gamification Reshapes Learning

Free eBook - How Gamification Reshapes Learning | AL_TU research | Scoop.it
The Learning Professionals Free Gamification eBook. Would you be interested in the Most Effective Uses of Gamification in Learning?

Via Louisa Lambregts
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Louisa Lambregts's curator insight, March 15, 7:43 AM

A series of articles from various elearning professionals regarding when gamification works the best.

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Small Wooden Building | Pavillon in Alberschwende

Small Wooden Building | Pavillon in Alberschwende | AL_TU research | Scoop.it
The "Pavilion for one Summer" was designed by Manuel Fabian Hartmann and his team attending the subject “design and construction” at the university of Innsbruck in the summer term 2013. The aim was...

Via Ionut Anton
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Ionut Anton's curator insight, December 4, 2013 11:33 PM

Lightweight parametric construction

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Everything I Know: 42 Hours of Buckminster Fuller’s Visionary Lectures Free Online (1975)

Everything I Know: 42 Hours of Buckminster Fuller’s Visionary Lectures Free Online (1975) | AL_TU research | Scoop.it
Think of the name Buckminster Fuller, and you may think of a few oddities of mid-twentieth-century design for living: the Dymaxion House, the Dymaxion Car, the geodesic dome.
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42 Hours of Buckminster Fuller’s Visionary Lectures

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Tough, Light and Strong: Lessons From Nature Could Lead to the Creation of New Materials

Tough, Light and Strong: Lessons From Nature Could Lead to the Creation of New Materials | AL_TU research | Scoop.it

In a sweeping review of the field of bio-inspired engineering and biomimicry in the Feb. 15 issue of the journal Science, two engineers at the University of California, San Diego, identify three characteristics of biological materials that they believe engineers would do well to emulate in man-made materials: light weight, toughness and strength.


Via Michele Diodati, TWNDigest, Dr. Stefan Gruenwald
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Knitting A Building: My Thread Pavilion for Nike - eVolo | Architecture Magazine

Knitting A Building: My Thread Pavilion for Nike - eVolo | Architecture Magazine | AL_TU research | Scoop.it
Architecture and Design Magazine for the 21st Century. Organizer of the Annual Skyscraper Architectural Competition.

Via Roberto S L Naboni
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Concrete Rapid Manufacturing | Rael San Fratello - Arch2O.com

Concrete Rapid Manufacturing | Rael San Fratello - Arch2O.com | AL_TU research | Scoop.it
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DNA disPLAY

DNA disPLAY - BioMod 2013 The DNA disPLAY project attempts to take-on the challenge of DNA design by making DNA both physical and visual as a new creative medium.…
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Mussel

Mussel | AL_TU research | Scoop.it
MUSSEL is a free and open source tool for generating RAPID code for ABB robots.  Most simply, it allows you to generate working code from a list of input plane…

Via Ionut Anton
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Ionut Anton's curator insight, October 20, 2013 7:55 AM

Open source tool for controlling ABB robots

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Exhibition showcases future of 3D printing

Exhibition showcases future of 3D printing | AL_TU research | Scoop.it

Via Andrea Graziano, Alessio Erioli
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YOU Reshape | Digital Craft Competition

YOU Reshape | Digital Craft Competition | AL_TU research | Scoop.it

Via Ionut Anton
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Ionut Anton's curator insight, October 18, 2013 4:12 AM

Reshape traditional craft with the digital competition

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Otwarcie Pawilonu P^3 Pavilion Opening | Facebook

Otwarcie Pawilonu P^3 Pavilion Opening | Facebook | AL_TU research | Scoop.it
Tudor Cosmatu's insight:

The p3 Pavilion is done! Join us for the opening ceremony on Sunday 20th October at 19:00!

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