This was a laboratory-based study. It aimed to determine whether the formation of fat cells – known as adipocytes – is influenced by the weight those cells are placed under, or the “mechanical loading/stresses”. Other types of cell have already been shown to be sensitive to the mechanical stress they are placed under. For example, bone cells – known as osteoblasts – produce mineralised bone when given sufficient mechanical stimulation. Although this is an appropriate study design to look at the formation of different cell types, it can’t prove that the mechanical pressure caused by sitting down contributes to bottom fat. This is for several reasons, including the fact that the study took place on fat cells in a laboratory, and did not look at fat cells in human bottoms.