Neuroscience: Parkinson's disease
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Link Between Head Injury and Parkinson's Gets Stronger

Link Between Head Injury and Parkinson's Gets Stronger | Neuroscience: Parkinson's disease | Scoop.it
There’s mounting evidence that even a single blow to the head can contribute to a higher risk of Parkinson’s even decades later
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Tau PET in Alzheimer disease and mild cognitive impairment

Tau PET in Alzheimer disease and mild cognitive impairment | Neuroscience: Parkinson's disease | Scoop.it
Objective:
To investigate the topographical distribution of tau pathology and its effect on functional and structural changes in patients with Alzheimer disease (AD) and mild cognitive impairment (MCI) by using 18F-AV-1451 PET.
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Transplantation of spinal cord–derived neural stem cells for ALS

Transplantation of spinal cord–derived neural stem cells for ALS | Neuroscience: Parkinson's disease | Scoop.it
Objective:
To test the safety of spinal cord transplantation of human stem cells in patients with amyotrophic lateral sclerosis (ALS) with escalating doses and expansion of the trial to multiple clinical centers.
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Autism and epilepsy

Autism and epilepsy | Neuroscience: Parkinson's disease | Scoop.it
Objective:
To investigate the risk of autism spectrum disorder (ASD) in individuals with epilepsy and in their first-degree relatives to determine shared etiology.
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Failure analysis of clinical trials to test the amyloid hypothesis

Failure analysis of clinical trials to test the amyloid hypothesis | Neuroscience: Parkinson's disease | Scoop.it
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The prion hypothesis of Parkinson's disease: This hot topic just got hotter

The prion hypothesis of Parkinson's disease: This hot topic just got hotter | Neuroscience: Parkinson's disease | Scoop.it
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MRI Scans Can Detect Early Onset of Parkinson's, Study Finds - TIME

MRI Scans Can Detect Early Onset of Parkinson's, Study Finds - TIME | Neuroscience: Parkinson's disease | Scoop.it
Medical Daily
MRI Scans Can Detect Early Onset of Parkinson's, Study Finds
TIME
Oxford University researchers say that by simply having a patient hold still in an MRI scanner, they can detect the early onset of Parkinson's disease.
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Parkinson disease: Low vitamin D and Parkinson disease a causal conundrum

Parkinson disease: Low vitamin D and Parkinson disease a causal conundrum | Neuroscience: Parkinson's disease | Scoop.it
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Cell - Isogenic Human iPSC Parkinson’s Model Shows Nitrosative Stress-Induced Dysfunction in MEF2-PGC1α Transcription

Cell - Isogenic Human iPSC Parkinson’s Model Shows Nitrosative Stress-Induced Dysfunction in MEF2-PGC1α Transcription | Neuroscience: Parkinson's disease | Scoop.it
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Dietary nicotine or other constituents of tobacco and peppers may reduce PD risk - Annals of Neurology

Dietary nicotine or other constituents of tobacco and peppers may reduce PD risk - Annals of Neurology | Neuroscience: Parkinson's disease | Scoop.it
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Insufficient evidence for valid biomarkers in Parkinson's disease progression

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Pimavanserin may benefit patients with Parkinson's disease psychosis : The Lancet

Pimavanserin for patients with Parkinson's disease psychosis: a randomised, placebo-controlled phase 3 trial. By - Jeffrey Cummings MD, Stuart Isaacson MD, Roger Mills MD, Hilde Williams, Kathy Chi...
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The Pesticide Connection - Chemical & Engineering News

The Pesticide Connection - Chemical & Engineering News | Neuroscience: Parkinson's disease | Scoop.it
After receiving a low daily dose of the pesticide rotenone for a week or two, rats in Greenamyre's lab begin to lose mobility in ways similar to Parkinson's patients. The rodents move at a glacial pace, they have trouble keeping ...
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Using stem cells to treat ALS

Using stem cells to treat ALS | Neuroscience: Parkinson's disease | Scoop.it
In their article "Transplantation of spinal cord–derived neural stem cells for ALS: Analysis of phase 1 and 2 trials," Glass et al.1 set out to study a specific question: Is the injection of human spinal cord–derived neural...
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Detecting depression in Parkinson disease

Detecting depression in Parkinson disease | Neuroscience: Parkinson's disease | Scoop.it
Background:
Failure to detect depression in patients with Parkinson disease (PD) can lead to worsened outcomes for patients and caregivers.
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Relation of genomic variants for Alzheimer disease dementia to common neuropathologies

Relation of genomic variants for Alzheimer disease dementia to common neuropathologies | Neuroscience: Parkinson's disease | Scoop.it
Objective:
To investigate the associations of previously reported Alzheimer disease (AD) dementia genomic variants with common neuropathologies.
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Progression and biomarkers for Parkinson disease

Progression and biomarkers for Parkinson disease | Neuroscience: Parkinson's disease | Scoop.it
The conceptualization of clinical aspects of Parkinson disease (PD) and its pathophysiology has changed considerably since Braak's description of a "bottom-up" progression of Lewy body pathology from the lower medulla and the olfactory...
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NIH scientists find six new genetic risk factors for Parkinson’s : National Institute of Neurological Disorders and Stroke (NINDS)

NIH scientists find six new genetic risk factors for Parkinson’s : National Institute of Neurological Disorders and Stroke (NINDS) | Neuroscience: Parkinson's disease | Scoop.it
NIH scientists find six new genetic risk factors for Parkinson’s

Via Krishan Maggon
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Mutant huntingtin is present in neuronal grafts in huntington disease patients

Mutant huntingtin is present in neuronal grafts in huntington disease patients | Neuroscience: Parkinson's disease | Scoop.it
ObjectiveHuntington disease (HD) is caused by a genetically encoded pathological protein (mutant huntingtin [mHtt]), which is thought to exert its effects in a cell-autonomous manner.
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How a “90% accurate” Alzheimer’s test can be wrong 92% of the time

How a “90% accurate” Alzheimer’s test can be wrong 92% of the time | Neuroscience: Parkinson's disease | Scoop.it
A widely reported academic paper published in the Nature journal claims to have a test that is “90% accurate” in detecting Alzheimer’s, three years before the disease develops
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Use of stem cell therapies for Parkinson's disease - International Parkinson and Movement Disorder Society - MDS

An international professional society invested in the research and care of patients with Movement Disorders,
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Advances in the pharmacological treatment of Parkinson's disease: targeting neurotransmitter systems

Advances in the pharmacological treatment of Parkinson's disease: targeting neurotransmitter systems | Neuroscience: Parkinson's disease | Scoop.it
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JCI - Exenatide and the treatment of patients with Parkinson’s disease

JCI - Exenatide and the treatment of patients with Parkinson’s disease | Neuroscience: Parkinson's disease | Scoop.it
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Household organophosphorus pesticide use and Parkinson’s disease

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Rescooped by Juan Piña-Crespo from Stem Cells & Tissue Engineering
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Identification and rescue of α-Synuclein toxicity in Parkinson's disease-associated neurons

Identification and rescue of α-Synuclein toxicity in Parkinson's disease-associated neurons | Neuroscience: Parkinson's disease | Scoop.it

Via Jacob Blumenthal
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Jacob Blumenthal's curator insight, November 1, 2013 6:22 AM

Parkinson's disease (PD) is a neurodegenerative disease typically characterized by loss of dopaminergic neurons in the substantia nigra region of the brain. Parkinson's disease dementia (PDD) affects 80% of PD patients, and is pathologically related to neuronal loss and aggregation of α-Synuclein (αSyn) (encoded by the SNCA gene) in the cerebral cortex area of the brain. In order to study the molecular characteristics of and mechanisms underlying PDD, researchers from the Whitehead Institute have generated induced pluripotent stem (iPS) cells from patient skin cells, harboring α-Synuclein mutations (A53T). In a parallel experiment, (click the image to read more).

 

Explore dopaminegic neurons development:

http://discovery.lifemapsc.com/in-vivo-development/dopaminergic-neurons