Neuroscience: Alzheimer's disease
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Age and neurodegeneration imaging biomarkers in persons with Alzheimer disease dementia

Age and neurodegeneration imaging biomarkers in persons with Alzheimer disease dementia | Neuroscience: Alzheimer's disease | Scoop.it
Objective:
To examine neurodegenerative imaging biomarkers in Alzheimer disease (AD) dementia from middle to old age.
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Case of a missing gene may help future Alzheimer's treatment

Case of a missing gene may help future Alzheimer's treatment | Neuroscience: Alzheimer's disease | Scoop.it
Research suggests that reducing or neutralizing one variety of the APOE gene would not harm the brain, while making Alzheimer’s less likely.

 

The 40-year-old man showed up in Dr. Mary Malloy’s clinic with sadly disfiguring symptoms. His hands, elbows, ears and feet were blemished with protruding pustules and tuber-like welts, some so painful it was hard for him to walk. He suffered from a rare genetic condition called dysbetalipoproteinemia, which caused his cholesterol levels to soar so high that pools of fatty tissue seemed to bubble up under his skin.


But there was something else about this patient. He was missing a gene that, when present in one form, greatly increases the risk of developing Alzheimer’s disease. Dr. Malloy, who co-directs the Adult Lipid Clinic at the University of California, San Francisco, and her colleagues saw an opportunity to answer an important neurological riddle: Does the absence of the gene — named apolipoprotein E, or APOE, after the protein it encodes — hurt the brain?


If a person with this rare condition were found to be functioning normally, that would suggest support for a new direction in Alzheimer’s treatment. It would mean that efforts — already being explored by dementia experts — to prevent Alzheimer’s by reducing, eliminating or neutralizing the effects of the most dangerous version of APOE might succeed without causing other problems in the brain.


The researchers, who reported their findings on Monday in the journal JAMA Neurology, discovered exactly that. They ran a battery of tests, including cognitive assessments, brain imaging and cerebrospinal fluid analyses. The man’s levels of beta-amyloid and tau proteins, which are markers of Alzheimer’s, gave no indication of neurological disease. His brain size was unaffected, and the white matter was healthy. His thinking and memory skills were generally normal.


“This particular case tells us you can actually live without any APOE in the brain,” said Dr. Joachim Herz, a neuroscientist and molecular geneticist at University of Texas Southwestern Medical Center, who was not involved in the research. “So if they were to develop anti-APOE therapies for Alzheimer’s, we would not have to worry about serious neurological side effects.”


Via Dr. Stefan Gruenwald
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Spreading of Amyloid, Tau, and Microvascular Pathology in Alzheimer's Disease: Findings from Neuropathological and Neuroimaging Studies

Spreading of Amyloid, Tau, and Microvascular Pathology in Alzheimer's Disease: Findings from Neuropathological and Neuroimaging Studies | Neuroscience: Alzheimer's disease | Scoop.it
Primary pathologies including amyloid-β (Aβ) plaques and neurofibrillary tangles (NFT) develop many years before the onset of dementia symptoms in Alzheimer's disease (AD).
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MIT researcher proposes to change the way we fund Alzheimer’s research - The Boston Globe

MIT researcher proposes to change the way we fund Alzheimer’s research - The Boston Globe | Neuroscience: Alzheimer's disease | Scoop.it
Based on the current rates of success in creating new drugs for Alzheimer’s disease, it could take 260 years until the next one is approved, according to an analysis led by a Massachusetts Institute of Technology economist.
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Dietary (-) epicatechin as a potent inhibitor of βγ-secretase APP processing

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Metabolomic Signatures in Peripheral Blood Associated with Alzheimer's Disease Amyloid-β-Induced Neuroinflammation

Metabolomic Signatures in Peripheral Blood Associated with Alzheimer's Disease Amyloid-β-Induced Neuroinflammation | Neuroscience: Alzheimer's disease | Scoop.it
Discovery of biomarkers in peripheral blood is a crucial step toward the early diagnosis and repetitive monitoring of treatment response for Alzheimer's disease (AD). Metabolomics is a promising technology that can identify unbiased biomarkers.
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Lack of Sleep Increases Levels of Protein that Cause Alzheimer's Disease: Study - Headlines & Global News

Lack of Sleep Increases Levels of Protein that Cause Alzheimer's Disease: Study - Headlines & Global News | Neuroscience: Alzheimer's disease | Scoop.it
Lack of Sleep Increases Levels of Protein that Cause Alzheimer's Disease: Study Headlines & Global News The researchers inserted a catheter into the spines of all the participants so that the team could measure the levels of amyloid-beta protein...
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While You Were Sleeping—Synapses Forged, Amyloid Purged ...

While You Were Sleeping—Synapses Forged, Amyloid Purged ... | Neuroscience: Alzheimer's disease | Scoop.it
Another sleep study, led by Jurgen Claassen at Radboud University in Nijmegen, the Netherlands, adds to the growing body of knowledge about how slumber affects brain levels of amyloid-β. In the June 2 JAMA Neurology, ....
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How a “90% accurate” Alzheimer’s test can be wrong 92% of the time

How a “90% accurate” Alzheimer’s test can be wrong 92% of the time | Neuroscience: Alzheimer's disease | Scoop.it
A widely reported academic paper published in the Nature journal claims to have a test that is “90% accurate” in detecting Alzheimer’s, three years before the disease develops
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Brain Differences in Infants at Differential Genetic Risk for Late-Onset Alzheimer Disease:  A Cross-sectional Imaging Study

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FDA offers new guidance on developing drugs for Alzheimer’s disease

Alzheimer's disease draft guidance
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Astrocytes and Aβ Conspire to Harm Synapses - AlzForum Alzheimer Research News

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Microglia Tamp Down Neurogenesis | The Scientist Magazine®

Microglia Tamp Down Neurogenesis | The Scientist Magazine® | Neuroscience: Alzheimer's disease | Scoop.it

The immune cells—known for clearing dead cells—also chew up live progenitors in neurogenic regions of mouse brains. 

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Towards a Unified Vision of Copper Involvement in Alzheimer's Disease: A Review Connecting Basic, Experimental, and Clinical Research

Towards a Unified Vision of Copper Involvement in Alzheimer's Disease: A Review Connecting Basic, Experimental, and Clinical Research | Neuroscience: Alzheimer's disease | Scoop.it
Copper is an essential micronutrient for physiological cell functioning and central nervous system (CNS) development.
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Alzheimer's disease drug-development pipeline: few candidates, frequent failures

Alzheimer’s disease (AD) is increasing in frequency as the global population ages. Five drugs are approved for treatment of AD, including four cholinesterase inhibitors and an N-methyl-D-aspartate (NMDA)-receptor antagonist. We have an urgent need to find new therapies for AD.
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Cortical Localization of Microbleeds in Cerebral Amyloid Angiopathy: An Ultra High-Field 7T MRI Study

Cortical Localization of Microbleeds in Cerebral Amyloid Angiopathy: An Ultra High-Field 7T MRI Study | Neuroscience: Alzheimer's disease | Scoop.it
The extent of cortical involvement of cerebral amyloid angiopathy (CAA)-related microbleeds (CMBs) remains unclear.
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Redes - El azote del Alzheimer, Redes - RTVE.es A la Carta

Redes - El azote del Alzheimer, Redes - RTVE.es A la Carta | Neuroscience: Alzheimer's disease | Scoop.it
Hasta hace poco, los médicos solo podían diagnosticar el Alzheimer cuando el avance de la enfermedad ya había causado estragos en el paciente y los síntomas eran evidentes.Con técnicas modernas de dia...

Via robertocarbajal
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Alzheimer's compound gradually lowers amyloid in mice brains ...

Alzheimer's compound gradually lowers amyloid in mice brains ... | Neuroscience: Alzheimer's disease | Scoop.it
Investigators discovered that the compound, dubbed 2-PMAP, is nontoxic in mice, easily gets into the brain and lowers the production of amyloid β and associated amyloid deposits. The researchers believe that a drug like ...
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Healthy Seniors Tested in Bid to Block Alzheimer's - Boston.com

Healthy Seniors Tested in Bid to Block Alzheimer's - Boston.com | Neuroscience: Alzheimer's disease | Scoop.it
Healthy Seniors Tested in Bid to Block Alzheimer's
Boston.com
Having lots of that gunky protein called beta-amyloid doesn't guarantee someone will get sick. But the big question: Could intervening so early make a difference for those who do?
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Isolation of glia from Alzheimer’s mice reveals inflammation and dysfunction - Accepted Manuscript

Abstract: Reactive astrocytes and microglia are associated with amyloid plaques in Alzheimer’s disease (AD). Yet, not much is known about the molecular alterations underlying this reactive phenotype.
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2014 Alzheimer's disease facts and figures

Abstract: This report discusses the public health impact of Alzheimer's disease (AD), including incidence and prevalence, mortality rates, costs of care, and overall effect on caregivers and society.
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Serum Brain-Derived Neurotrophic Factor and the Risk for Dementia:  The Framingham Heart Study

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How Cognitive Stimulation Might Protect Against Aβ Oligomers - AlzForum Alzheimer Research Live Discussions

How Cognitive Stimulation Might Protect Against Aβ Oligomers - AlzForum Alzheimer Research Live Discussions | Neuroscience: Alzheimer's disease | Scoop.it
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