A Tale of Two Medicines
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A Tale of Two Medicines
Natural Medicine, Pharmaceuticals and GMO’s, the Good, the Bad and the OMG! - (The information provided is not intended to be a substitute for professional medical advice, diagnosis or treatment.  Never disregard professional medical advice, or delay in seeking it, because of something you have read on this scoopit page.)
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Dietary cadmium exposure and prostate cancer incidence: a population-based prospective cohort study

Dietary cadmium exposure and prostate cancer incidence: a population-based prospective cohort study | A Tale of Two Medicines | Scoop.it

 

Experimental data convincingly propose the toxic metal cadmium as a prostate carcinogen. Cadmium is widely dispersed into the environment and, consequently, food is contaminated.

 

A population-based cohort of 41 089 Swedish men aged 45–79 years was followed prospectively from 1998 through 2009 to assess the association between food frequency questionnaire-based estimates of dietary cadmium exposure (at baseline, 1998) and incidence of prostate cancer (3085 cases, of which 894 were localised and 794 advanced) and through 2008 for prostate cancer mortality (326 fatal cases).

 

Mean dietary cadmium exposure was 19 μg per day±s.d. 3.7. Multivariable-adjusted dietary cadmium exposure was positively associated with overall prostate cancer, comparing extreme tertiles; rate ratio (RR) 1.13 (95% confidence interval (CI): 1.03–1.24). For subtypes of prostate cancer, the RR was 1.29 (95% CI: 1.08–1.53) for localised, 1.05 (95% CI: 0.87–1.25) for advanced, and 1.14 (95% CI: 0.86–1.51) for fatal cases. No statistically significant difference was observed in the multivariable-adjusted risk estimates between tumour subtypes (Pheterogeneity=0.27). For localised prostate cancer, RR was 1.55 (1.16–2.08) among men with a small waist circumference and RR 1.45 (1.15, 1.83) among ever smokers.

 

Our findings provide support that dietary cadmium exposure may have a role in prostate cancer development.

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Defective Genes "Cause" Less Than 1% Of All Disease

Defective Genes "Cause" Less Than 1% Of All Disease | A Tale of Two Medicines | Scoop.it

 

In the mainstream media (and the popular consciousness programmed to consume it) defective genes are spoken about as if they were "disease time bombs," fatalistically programmed to go off inside of us, thanks to flawed genetic contributions of our ancestors. And yet, despite common misconceptions, monogenic diseases, or diseases that result from errors in the nucleotide sequence of a single gene are exceedingly rare.  In fact, less than 1% of all diseases fall within this category...

 

Following the completion of the Human Genome Project (HGP) in 2003 it is no longer accurate to say that our genes "cause" disease, any more than it is accurate to say that DNA is sufficient to account for all the proteins in our body. Despite initial expectations, the HGP revealed that there are only 20,000-25,000 genes in human DNA (genome), rather than the 100,000 + believed necessary to encode the 100,000 + proteins found in the human body (proteome).

 

Did you follow that? There are not even enough genes in the human body to account for the existence of the basic protein building blocks that make it possible, much less explain the behavior of these proteins in health and disease states!

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Toxic UK: pesticide levels in our food are rising

Toxic UK: pesticide levels in our food are rising | A Tale of Two Medicines | Scoop.it

A new report by the Pesticide Action Network UK has found that contrary to many people’s assumptions, levels of pesticide residues in our food have risen over the last few years.

 

The report Pesticides on a Plate shows that 46% of the food surveyed contains residues of one or more pesticides. This figure has increased every year and has almost doubled since 2003 when it was just 25%.

 

As well as fruit and veg, bread and flour also rank highly. Moreover, several fruit categories had residues exceeding Government limits.

 

The figures are based on an analysis of government tests looking for hundreds of different pesticides in everyday foods. This reanalysis by PAN-UK shows that overall as much as 40% of the food we eat contains residues of highly toxic substances that have been linked with developmental defects, cancers and other disorders.

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Combined effects of curcumin and triptolide on an ovarian cancer cell line.

Background: As natural medicines in Asia, curcumin and triptolide extracted from different drug plants have proven to possess anticancer potential and widely used for anti-cancer research. The present study attempted to clarify that curcumin and triptolide synergistically suppress ovarian cancer cell growth in vitro. Methods: To test synergic effects, cell viability and apoptosis were analyzed after curcumin and triptolide combination treatment on ovarian cancer cell lines. Synergistic effects on apoptosis induction were determined by lactate dehydrogenase (LDH) leakage assay, intracellular reactive oxygen species (ROS) assay, mitochondrial membrane potential (MMP) loss assay and flow cytometry analysis. Critical regulators of cell proliferation and apoptosis related were analyzed by qRT-PCR and Western blotting. Results: We showed that the combination of curcumin and triptolide could synergistically inhibit ovarian cancer cell growth, and induce apoptosis, which is accompanied by HSP27 and HSP70, indicating that HSP27 and HSP70 play the important role in the synergic effect. Conclusions: From the result present here, curcumin and triptolide combination with lower concentration have a synergistic anti-tumor effect on ovarian cancer and which will have a good potential in clinical applications.

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Warning: Psychiatric Drug Withdrawal Effects Can Persist Months, Even Years After Stopping Them.

Warning: Psychiatric Drug Withdrawal Effects Can Persist Months, Even Years After Stopping Them. | A Tale of Two Medicines | Scoop.it

Many people who have taken psychiatric drugs have found out the withdrawal effects of the drugs can persist for months, even years after they stop taking them.  Patient’s are frequently  not warned about this, and are often told that it is simply symptoms of their ‘mental disorder’ returning – yet studies confirm that after patient’s stop taking certain psychiatric drugs, the withdrawal effects may last several months to years afterwards.

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Natural cure for cataracts, glaucoma validated

Natural cure for cataracts, glaucoma validated | A Tale of Two Medicines | Scoop.it

Can extracts of bitter kola (Garcinia kola), garden egg (Solanum melongena) and pepper fruit (Dennettia tripetala) provide the elusive natural cure for eye diseases especially cataracts and glaucoma? CHUKWUMA MUANYA writes.


UNTIL now, they are renowned for their bitter and peppery tastes. They have been validated in clinical trials for treating various ailments such as osteoarthritis, food poisoning, indigestion, and heartburn, among many other disease indications.

 

  But now researchers are adding more feathers to their caps. Extracts of bitter kola, garden egg and pepper fruit have shown promise as the next best eye drugs in town. 

 

  Garcinia kola of the family Guttiferaceae is an indigenous herb in Nigeria colloquially referred to as “bitter kola”, “false kola” or “male kola.” Garcinia kola has been shown to have anti-inflammatory, anti-parasitic, antimicrobial and antiviral properties. 

 

  Botanically called Dennettia tripetala, pepper fruit belongs to the plant family Annonaceae. It is called Ako in Edo, Nkarika in Ibibio, Mmimi in Igbo, and Ata igbere in Yoruba.

 

  Botanically called Solanum melongena, garden egg or bitter tomato is an economic flowering plant belonging to the family Solanaceae.

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Researchers to study vitamin C as treatment for septic lung injury

Researchers to study vitamin C as treatment for septic lung injury | A Tale of Two Medicines | Scoop.it

 

Researchers from Virginia Commonwealth University will lead a multicenter $3.2 million National Institutes of Health grant to study whether high doses of vitamin C can effectively treat septic lung injury resulting from infection. The VCU team will collaborate with colleagues from Wake Forest Baptist Medical Center, the University of Virginia and Emory University to begin phase 2 clinical trials.

Sepsis is caused by the immune system’s response to a serious infection and is characterized by systemic inflammation, organ dysfunction and organ failure. Four out of 10 septic patients develop lung injury. Despite modern advances in critical care, one-third to half of all severely septic patients die, resulting in millions of deaths globally each year.

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Pseudogenes Regulate Immune Responses in Humans

Pseudogenes Regulate Immune Responses in Humans | A Tale of Two Medicines | Scoop.it

 

Pseudogenes were once thought to be nothing but genomic fossils—the remnants of broken genes. Now they are being shown to be highly functional and critical to life processes in the cell. Pseudogenes clearly play an active role in regulating chronic inflammation in humans, a key cellular process that is associated with cancer, autoimmune disorders and cardiovascular and neurodegenerative diseases.

 

Amazingly, scientists documented the activity of 2,082 distinct pseudogenes in the human genome whose aberrant levels of activity were directly associated with cancer-specific pathologies.

 

Another large-scale pseudogene analysis has also just been published. This time the focus of study was the determination of pseudogene activity in relation to tissue inflammation. The chronic inflammation of tissues in the human body is a key feature related to diseases associated with autoimmune responses, cardiovascular disorders, and neurodegenerative conditions. The research and its results not only showed how large groups of pseudogenes were involved in the inflammation response, but also allowed for the specific targeting of some of them to determine their function.

 

One such pseudogene that was targeted for study, was named “Lethe,” which turned out to be a master regulator of the inflammation response—turning it off when it was no longer needed. Thus, one of the key regulatory switches in the genome that keeps inflammation in check, is a pseudogene! Not bad for what evolutionists once thought to be a useless genomic fossil.

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FDA Sharing Patients’ Private Medical Records in Order to Harass Integrative Doctors

FDA Sharing Patients’ Private Medical Records in Order to Harass Integrative Doctors | A Tale of Two Medicines | Scoop.it

 

ANH-USA has learned that the FDA is working with state medical boards behind the scenes—sometimes in violation of the law.

 

According to our sources, professional medical boards are launching investigative actions against integrative physicians not because of patient complaints, but because of materials forwarded to them by the FDA before they are made public. These boards are treating the FDA documents as if they were formal complaints.

 

In other words, the US Food and Drug Administration, which is barred from interfering with the practice of medicine, is in fact deliberately but secretly ignoring the rules—something practitioners and consumers alike need to be warned about.

 

We suspect, but cannot yet prove, that this is widespread and is being orchestrated by a shadowy private group called the Association of State Medical Boards.

 

Today we will offer just a few examples:

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Black raspberry-derived anthocyanins demethylate tumor suppressor genes through the inhibition of DNMT1 and DNMT3B in colon cancer cells.

We previously reported that oral administration of black raspberry powder decreased promoter methylation of tumor suppressor genes in tumors from patients with colorectal cancer. The anthocyanins (ACs) in black raspberries are responsible, at least in part, for their cancer-inhibitory effects. In the present study, we asked if ACs are responsible for the demethylation effects observed in colorectal cancers. Three days of treatment of ACs at 0.5, 5, and 25 μg/ml suppressed activity and protein expression of DNMT1 and DNMT3B in HCT116, Caco2 and SW480 cells. Promoters of CDKN2A, and SFRP2, SFRP5, and WIF1, upstream of Wnt pathway, were demethylated by ACs. mRNA expression of some of these genes was increased. mRNA expression of β-catenin and c-Myc, downstream of Wnt pathway, and cell proliferation were decreased; apoptosis was increased. ACs were taken up into HCT116 cells and were differentially localized with DNMT1 and DNMT3B in the same cells visualized using confocal laser scanning microscopy. Although it was reported that DNMT3B is regulated by c-Myc in mouse lymphoma, DNMT3B did not bind with c-Myc in HCT116 cells. In conclusion, our results suggest that ACs are responsible, at least in part, for the demethylation effects of whole black raspberries in colorectal cancers.

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How antibiotics enable pathogenic gut infections

How antibiotics enable pathogenic gut infections | A Tale of Two Medicines | Scoop.it

 

 

A new study by researchers at the Stanford University School of Medicine could help pinpoint ways to counter the effects of the antibiotics-driven depletion of friendly, gut-dwelling bacteria.

 

 

A number of intestinal pathogens can cause problems after antibiotic administration, said Justin Sonnenburg, PhD, assistant professor of microbiology and immunology and the senior author of the study, to be published online Sept. 1 in Nature. Graduate students Katharine Ng and Jessica Ferreyra shared lead authorship.

 

 

“Antibiotics open the door for these pathogens to take hold. But how, exactly, that occurs hasn’t been well understood,” Sonnenburg said.

 

 

In the first 24 hours after administration of oral antibiotics, a spike in carbohydrate availability takes place in the gut, the study says. This transient nutrient surplus, combined with the reduction of friendly gut-dwelling bacteria due to antibiotics, permits at least two potentially deadly pathogens to get a toehold in that otherwise more forbidding environment.

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Swine study suggests flu vaccination may sometimes backfire

Swine study suggests flu vaccination may sometimes backfire | A Tale of Two Medicines | Scoop.it

During the 2009 H1N1 pandemic, Canadian researchers identified a greater risk of infection in those who had been vaccinated against seasonal flu, a puzzling finding that researchers are still unraveling, including a group yesterday that revealed more about a mechanism for the process through experiments on pigs.

 

The heightened risk identified during the 2009 pandemic threatened to disrupt vaccination efforts in Canada, and the findings raised tough issues for policymakers, especially when studies in the United States and other countries contradicted the Canadian findings. However, in 2010 a large study by a Canadian team put an exclamation point on the earlier findings, reporting that the risk of needing treatment for pandemic flu was 1.4 to 2.4 times greater in those who had been vaccinated against seasonal flu in the previous year.

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Venus Flytrap (Dionaea muscipula Solander ex Ellis) Contains Powerful Compounds that Prevent and Cure Cancer

Venus Flytrap (Dionaea muscipula Solander ex Ellis) Contains Powerful Compounds that Prevent and Cure Cancer | A Tale of Two Medicines | Scoop.it

Chemoprevention uses natural or synthetic molecules without toxic effects to prevent and/or block emergence and development of diseases including cancer. Many of these natural molecules modulate mitogenic signals involved in cell survival, apoptosis, cell cycle regulation, angiogenesis, or on processes involved in the development of metastases occur naturally, especially in fruits and vegetables bur also in non-comestible plants. Carnivorous plants including the Venus flytrap (Dionaea muscipula Solander ex Ellis) are much less investigated, but appear to contain a wealth of potent bioactive secondary metabolites. Aim of this review is to give insight into molecular mechanisms triggered by compounds isolated from these interesting plants with either therapeutic or chemopreventive potential.

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A Randomized, Placebo-Controlled, Crossover Study of an Herbal Preparation Containing Vernonia cinerea in the Treatment of Type 2 Diabetes

A Randomized, Placebo-Controlled, Crossover Study of an Herbal Preparation Containing Vernonia cinerea in the Treatment of Type 2 Diabetes | A Tale of Two Medicines | Scoop.it

A randomized, single-center, double-blind, crossover clinical trial investigated the effects of an herbal preparation containing Vernonia cinerea in patients with type 2 diabetes mellitus.

 

48 patients with type 2 diabetes mellitus for longer than 6 months were divided into two groups matched for demographic and paraclinical variables. One group received a standard preparation of V. cinerea for 3 months, followed by placebo for another 3 months, and the other group received treatment in the reverse order. All patients received detailed advice on diet, exercise, and lifestyle modification. Glucose level was documented every 2 weeks, and hemoglobin A1c, total cholesterol, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein cholesterol, triglycerides, aspartate aminotransferase, alanine aminotransferase, and creatinine levels were determined at recruitment, 3 months, and study completion at 6 months.

 

Glucose, hemoglobin A1c, cholesterol, LDL cholesterol, and triglyceride levels decreased significantly in both groups. No significant differences were seen in aspartate aminotransferase, alanine aminotransferase, or creatinine levels, indicating that use of the herbal preparation had no adverse effect on liver or renal function.

 

Herbal treatment with V. cinerea has a beneficial effect on reducing the glycemic state in patients with type 2 diabetes.

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Major Pharmaceutical Company Wants To Block Access To Clinical Trial Data Of Their Drugs In Fear of Profit Loss

Major Pharmaceutical Company Wants To Block Access To Clinical Trial Data Of Their Drugs In Fear of Profit Loss | A Tale of Two Medicines | Scoop.it

AbbVie (recently split off from Abbott Laboratories), maker of Humira, and InterMune, maker of Esbriet, have filed a lawsuit against the European Medicines Agency (the European equivalent of the FDA) to block access to clinical trial data on the benefits and harms of their drugs, claiming that these vital facts are “trade secrets” whose release would harm their profits. Medical researches have been denied to clinical trial information.

 

Of course, when a drug causes cancer, release of clinical data information could potentially harm the profits of the company that makes it. Humira, a drug that is quickly becoming one of the best-selling drugs in the world, mainly because of the marketing techniques used by AbbVie, causes cancer.

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Tropical herb a ‘breakthrough’ in treating candida

Tropical herb a ‘breakthrough’ in treating candida | A Tale of Two Medicines | Scoop.it

A herb native to the tropical forests of southern and central India and Sri Lanka could be a breakthrough treatment for a common human fungal pathogen that lives in almost 80% of us.

 

Researchers at Kansas State University, led by Govindsamy Vediyappan, assistant professor of biology, noticed that diabetic people in developing countries use a medicinal herb called Gymnema slyvestre to help control sugar levels.

 

He decided to study the microbiological use of G. slyvestre to see if it could treat a common human fungal pathogen called Candida albicans.

The investigation was successful in two ways: the medicinal compound was found to be both nontoxic as well as having the ability to block the virulence properties of the fungus making it more treatable.

 

“We have shown that this compound is safe to use because it doesn’t hurt our body cells, yet it blocks the virulence of this fungus under in vitro conditions,” Vediyappan said. “Taking the medicine could potentially help patients control the invasive growth of the fungus and also help bring their sugar levels down.”

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Allium Vegetables and Risk of Prostate Cancer: Evidence from 132,192 Subjects

Allium Vegetables and Risk of Prostate Cancer: Evidence from 132,192 Subjects | A Tale of Two Medicines | Scoop.it

 Objective: To evaluate the relationship between allium vegetable intake and risk of prostate cancer. Methods: A systematic literature search up to May 2013 was carried out in PubMed, EMBASE, Scopus, Web of Science, Cochrane register, and Chinese National Knowledge Infrastructure (CNKI) databases, and the references of retrieved articles were also screened. The summary relative risks with 95% confidence interval for the highest versus the lowest intake of allium vegetables were calculated. Heterogeneity and publication bias were also evaluated. Results: A total of nine epidemiological studies consisting of six case–control and three prospective cohort studies were included. We found a significantly decreased risk of prostate cancer for intake of allium vegetables (OR = 0.82, 95% CI 0.70, 0.97). Moreover, in the subgroup analysis stratified by allium vegetable types, significant associations were observed for garlic (OR = 0.77, 95% CI 0.64–0.91) but not onions (OR = 0.84, 95% CI 0.62–1.13). Conclusions: Allium vegetables, especially garlic intake, are related to decreased risk of prostate cancer. Because of the limited number of studies, further well-designed prospective studies are warranted to confirm the findings of our study.

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Antioxidant, anti-inflammatory and antinociceptive activities of essential oil from ginger.

Chemical compositions of ginger oil as well as its antioxidant, anti-inflammatory and antinociceptive potential were evaluated in the present study. The main constituents as detected by GC/MS analysis was alpha-zingiberene which constituted 31% of the total area, ar-curcumene (15.4%) and a -sesquiphellandrene (14.02%). Ginger oil scavenged superoxide, DPPH, hydroxyl radicals and inhibited tissue lipid peroxidation in vitro. Intraperitoneal administration of ginger oil was found to inhibit phorbol-12-myristate-13-acetate induced superoxide radicals elicited by macrophages. Oral administration of ginger oil for one month, significantly increased superoxide dismutase, glutathione and glutathione reductase enzymes level (P < 0.001) in blood of mice and glutathione-S-transferase, glutathione peroxidase and superoxide dismutase enzymes in liver. Ginger oil produced significant reduction in acute inflammation produced by carrageenan and dextran and formalin induced chronic inflammation (P < 0.001). It also exhibited significant reduction in acetic acid induced writhing movements (P < 0.001). The present report revealed that ginger oil possesses antioxidant activity as well as significant anti-inflammatory and antinociceptive property.

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Brand New Glutathione Supplement That Enhances Cellular Health

Announcing the launch of this total immune health supplement SynergiaGSH in March of 2013, it could quite possibly be the biggest news in the health world this year.

SynergiaGSH is a brand new Glutathione enhancing supplement that is completely void of fillers and harmful dyes. Outshining all other Glutathione enhancing supplements with an ingredient list that is unmatched in quality and effectiveness.

Over 100,000 medical articles have been done on Glutathione, proving just how important this “Master Antioxidant” is to total immune health and cellular function. With big name celebrities like Suzanne Somers and Dr Oz touting its benefits, it is growing in popularity and becoming the most important supplement anyone could take to improve overall health and well-being.

Previously the best way to enhance Glutathione levels was to supplement the amino building blocks which promote production within the cells. Using these precursors combined with the bioavailable form of Glutathione to raise levels directly, SynergiaGSH far outweighs the benefits of virtually every supplement on the market.

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Meta-analysis Suggests Vitamin C Protective Against Acute Kidney Injury.

Meta-analysis Suggests Vitamin C Protective Against Acute Kidney Injury. | A Tale of Two Medicines | Scoop.it

Vitamin C appears to reduce the risk of contrast-induced acute kidney injury (AKI) by one-third in patients undergoing coronary angiography, reports a meta-analysis published online August 28, 2013, in the Journal of the American College of Cardiology. However, additional research is required to determine optimal dose and administration route.

 

Investigators led by Umar Sadat, MD, PhD, of Addenbrooke’s Hospital (Cambridge, United Kingdom), identified 9 randomized controlled trials reporting on contrast-induced AKI in 1,536 patients that were published between 2004 and 2013. Patients were assigned to ascorbic acid (with or without saline hydration; n = 740) vs. saline hydration, placebo, or other nephroprotective agents such as N-acetylcysteine (n = 796).

 

Ascorbic acid was administered intravenously or orally and given before, during, and after treatment. Doses varied. AKI (defined as an absolute increase in serum creatinine ≥ 0.5 mg/dL or a relative increase ≥ 25% from baseline following contrast administration) was assessed anywhere from 24 hours to 5 days after angiography.

 

Consistently Lower Risk


The incidence of contrast-induced AKI was lower for patients who received ascorbic acid compared with those given placebo, saline alone, or an alternate pharmacological treatment (9.59% vs. 16.83%).

 

Using a random effects model, Dr. Sadat and colleagues calculated that the ascorbic acid group had a lower risk of developing AKI (RR 0.672; 95% CI 0.466-0.969; P = 0.034). Heterogeneity among studies was low and did not reach statistical significance. Additional analyses including a fixed effects model and removal of individual studies from the pool showed consistent benefit with ascorbic acid. Publication bias was deemed unlikely

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Coffee Good for Mental Health and Reduces Suicide Risk, Study Finds

Coffee Good for Mental Health and Reduces Suicide Risk, Study Finds | A Tale of Two Medicines | Scoop.it

For years, coffee has suffered a bad rap, suspected of causing high blood pressure and contributing to heart disease, ulcers, and diabetes.

 

Most recently, Senator Durbin used caffeinated energy drinks as an example of the dangerous and ‘unregulated’ supplement industry, which he proposes should be regulated like the drug industry. But mounting research is casting doubt on the “common wisdom” that coffee is nothing but bad for you.

 

Certainly, coffee should not be used in excess. However, study after study has failed to prove that moderate coffee consumption increases your risk for cardiovascular disease or any other serious illness.

 

In fact, it’s beginning to look like coffee—at least in moderation—may have a number of unrecognized health-promoting properties.

 

Part of the confusion is that while caffeine in and of itself is a potent and addictive drug, coffee made from whole roasted coffee beans is also a whole food, containing a wide range of micronutrients in addition to caffeine.

 

As a result of evaluating the growing list of therapeutic benefits, I’ve changed my recommendations on coffee consumption, placing the emphasis on making sure it’s fresh, organic, and consumed black, should you decide to drink it.

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Will Gourley's curator insight, September 11, 2013 8:10 PM

Finally! Science has caught up to my opinion. Coffee is awesome and prevents me from a myriad of potential mental health issues. Now hand it over!

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Active extracts of black tea (Camellia Sinensis) induce apoptosis of PC-3 prostate cancer cells via mitochondrial dysfunction.

Cancer of the prostate gland is the most common invasive malignancy and the second leading cause of cancer-related death in human males. Many studies have shown that black tea reduces the risk of several types of cancer. We studied the effects of active extracts of black tea and the black tea polyphenols theaflavins (TFs), on the cellular proliferation and mitochondria of the human prostate cancer cell line PC-3. Our studies revealed that Yinghong black tea extracts (YBT), Assam black tea extracts (ABT) and TFs inhibited cell proliferation in a dose-dependent manner. We also showed that TFs, YBT and ABT affected the morphology of PC-3 cells and induced apoptosis or even necrosis in PC-3 cells. In addition, it was observed that the samples significantly caused loss of the mitochondrial membrane potential, release of cytochrome c from the intermembrane space into the cytosol, decrease of the ATP content and activation of caspase-3 compared with the control. Taken together, these findings suggest that black tea could act as an effective anti-proliferative agent in PC-3 cells, and TFs, YBT and ABT induced apoptosis of PC-3 cells through mitochondrial dysfunction.

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Mulberry Leaf Extract May Lower Blood Sugar Spikes

Mulberry Leaf Extract May Lower Blood Sugar Spikes | A Tale of Two Medicines | Scoop.it

 

Plant extracts are common in Asian countries, especially in Chinese Traditional Medicine practices. Mulberry leaf is used in Asia to treat type 2 diabetes as it appears to lower fasting blood glucose and A1C concentrations in small studies. Another study has been conducted, this time on healthy subjects, to evaluate the potential of mulberry leaf extract on preventing blood sugar spikes that can increase the risk of insulin resistance and developing diabetes.

 

Korean researchers from Ewha Women’s University and the Seoul National University of Science and Technology recruited 50 healthy people that were randomly assigned to one of five groups. Four received a maltose powder drink, followed by varying amounts of mulberry leaf extract. The fifth group took the extract 30 minutes before the maltose beverage.

 

The effective doses appeared to be 2.5 to 5 grams of mulberry leaf aqueous extract. There was no difference in response whether the extract was taken before the beverage or at the same time.

 

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How To Clean Your Arteries With One Simple Fruit

How To Clean Your Arteries With One Simple Fruit | A Tale of Two Medicines | Scoop.it

 

A new study published in the journal Atherosclerosis confirms that pomegranate extract may prevent and/or reverse the primary pathology associated with cardiac mortality: the progressive thickening of the coronary arteries caused by the accumulation of fatty materials known as atherosclerosis.

 

Mice with a genetic susceptibility towards spontaneous coronary artery blockages were given pomegranate extract via their drinking water for two weeks, beginning at three weeks of age. Despite the fact that pomegranate treatment actually increased cholesterol levels associated with very low density lipoprotein-sized particles, the treatment both reduced the size of the atherosclerotic plaques in the aortic sinus (the dilated opening above the aortic valve) and reduced the proportion of coronary arteries with occlusive atherosclerotic plaques.

 

Remarkably, the researchers also found that pomegranate extract treatment resulted in the following beneficial effects:

Reduced levels of oxidative stressReduced monocytie chemotactic protein-1, a chemical messenger (chemokine) associated with inflammatory processes within the arteries.  Reduced lipid accumulation in the heart muscleReduced macrophage infiltration in the heart muscleReduced levels of monocyte chemotactic protein-1 and fibrosis in the myocardiumReduced cardiac enlargementReduced ECG abnormalities
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Plant polyphenols may modulate microbiota: In vitro study

Plant polyphenols may modulate microbiota: In vitro study | A Tale of Two Medicines | Scoop.it
Plant polyphenols may modulate microbiota: In vitro study. Post a comment. By Nathan Gray+. 27-Aug-2013. Phenolic compounds found in black tea and red wine grape extracts could modify the composition of microbes in our gut, say ...
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