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Alternatives and refinements to animal research
News about the replacement and reduction of animals in scientific research, and improvements in welfare practice.
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Industry Council Formed to Advance Regulatory Acceptance of Non-Animal Testing Methods - The Sacramento Bee

Industry Council Formed to Advance Regulatory Acceptance of Non-Animal Testing Methods - The Sacramento Bee | Alternatives and refinements to animal research | Scoop.it
/PRNewswire-USNewswire/ -- The Institute for In Vitro Sciences Inc., (IIVS) a world renowned leader in the validation, training, and application of non-animal test methods, announces the formation of ICARAA: Industry Council for the Advancement of...
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Scientists develop worm EEG to test the effects of drugs

Scientists develop worm EEG to test the effects of drugs | Alternatives and refinements to animal research | Scoop.it
Scientists have developed a device which records the brain activity of worms to help test the effects of drugs.
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Lindy Holden-Dye, Professor of Neuroscience at the University of Southampton and lead author of the paper, says: "We are particularly interested in using this as a sensitive new tool for screening compounds for neurotoxicity. It will allow us to precisely quantify sub-lethal effects on neural network activity. It can also provide an information rich platform by reporting the effects of compounds on a diverse array of neurotransmitter pathways, which are implicated in mammalian toxicology.

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EURL Ecvam to provide more alternative testing methods information

The European Union Reference Laboratory for Alternatives to Animal Testing (EURL Ecvam) should provide more detailed information on the status of alternative testing methods under validation or evaluation, according to the conclusions of a meeting...
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Taking memory research to Parliament | NC3Rs blog

Taking memory research to Parliament | NC3Rs blog | Alternatives and refinements to animal research | Scoop.it
NC3Rs PhD student Kam Ameen-Ali blogs about taking memory research to parliament http://t.co/7HilS46S7H #3Rs #womeninscience #neuroscience
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Our first PhD student to publish a research paper on her work blogs about her experience at this year's SET for BRITAIN

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Reporting of Research | Epilepsy Research

Reporting of Research | Epilepsy Research | Alternatives and refinements to animal research | Scoop.it
@E_R_U_K Epilepsy Research UK now support the #ARRIVEguidelines http://t.co/QUZYULv1IN
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Epilepsy Research UK signs up to the ARRIVE guidelines

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NC3Rs launches new blog

NC3Rs launches new blog | Alternatives and refinements to animal research | Scoop.it
Read about the 3Rs prize-winning lung-on-a-chip microdevice on the new NC3Rs blog
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Blog: Replacing rodents in CNS studies

Blog: Replacing rodents in CNS studies | Alternatives and refinements to animal research | Scoop.it
Professor Sue Barnett challenges the dogma that animal studies of spinal cord injury can't be replaced
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The Welfare of Lab Animals Should Be Considered Every Day, Not Just Once a Year

The Welfare of Lab Animals Should Be Considered Every Day, Not Just Once a Year | Alternatives and refinements to animal research | Scoop.it
One criticism of World Day for Laboratory Animals, is that protest groups tend to paint a very one-sided picture of animal research and are rather selective in their reporting.
National Centre for the 3Rs - Pioneering Better Science's insight:

In the UK, the government-backed National Centre for the 3Rs (NC3Rs) leads the way in funding projects that promote replacement, refinement and reduction, with the 3Rs now also enshrined in law and embedded in the Home Office licensing system. Some exciting replacement technologies are on the horizon, such as the recent news that a research team from Harvard was awarded the NC3Rs prize for animal replacement potential for a micro-device containing hollow channels lined with living human tissue cells.

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Applying smarter science to cancer research | NC3Rs blog

Applying smarter science to cancer research | NC3Rs blog | Alternatives and refinements to animal research | Scoop.it

Cancers are often resistant to chemotherapy. New drugs and novel approaches to finding those drugs are needed in the ongoing battle against one of the UK’s biggest killers. Dan Richards talks to NC3Rs David Sainsbury Fellow, Dr Adrian Biddle, Queen Mary, University of London, who is working on a new non-animal in vitro method for the development of drugs to target cancer stem cells. Dr Biddle talks about life as a fellow and his hopes for faster progress in the development of anticancer therapies with an approach that replaces the need for animals

National Centre for the 3Rs - Pioneering Better Science's insight:

There is therefore a range of benefits from applying 3Rs principles to cancer stem cell research, and this will hopefully drive faster progress across industry and academia in the search for anticancer therapies.

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Why not use human material for medical research? | NC3Rs blog

Why not use human material for medical research? | NC3Rs blog | Alternatives and refinements to animal research | Scoop.it
National Centre for the 3Rs - Pioneering Better Science's insight:

Using human tissue in medical research throws up a number of different challenges. In our third 2012 NC3Rs 3Rs Prize post, Professor Gareth Sanger from Queen Mary, University of London, discusses how tissue removed from the stomach and intestine can actually help overcome some of these challenges. Is this a viable alternative to using animals for gastrointestinal research? Professor Sanger’s research suggests it could be.

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Cranking Out New Models | The Scientist Magazine®

Cranking Out New Models | The Scientist Magazine® | Alternatives and refinements to animal research | Scoop.it
Scientists make mice strains with multiple mutations in less than a month without using embryonic stem cells.
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Game-changing method for breeding GM mice that drastically reduces mice used to one generation #3Rs

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Injectable nano-network controls blood sugar in diabetics for days at a time

Injectable nano-network controls blood sugar in diabetics for days at a time | Alternatives and refinements to animal research | Scoop.it

In a promising development for diabetes treatment, researchers have developed a network of nanoscale particles that can be injected into the body and release insulin when blood-sugar levels rise, maintaining normal blood sugar levels for more than a week in animal-based laboratory tests. The work was done by researchers at North Carolina State University, the University of North Carolina at Chapel Hill, the Massachusetts Institute of Technology and Children's Hospital Boston.

 

The new, injectable nano-network is composed of a mixture containing nanoparticles with a solid core of insulin, modified dextran and glucose oxidase enzymes. When the enzymes are exposed to high glucose levels they effectively convert glucose into gluconic acid, which breaks down the modified dextran and releases the insulin. The insulin then brings the glucose levels under control. The gluconic acid and dextran are fully biocompatible and dissolve in the body.

 

Each of these nanoparticle cores is given either a positively charged or negatively charged biocompatible coating. The positively charged coatings are made of chitosan (a material normally found in shrimp shells), while the negatively charged coatings are made of alginate (a material normally found in seaweed).

 

When the solution of coated nanoparticles is mixed together, the positively and negatively charged coatings are attracted to each other to form a "nano-network." Once injected into the subcutaneous layer of the skin, the nano-network holds the nanoparticles together and prevents them from dispersing throughout the body. Both the nano-network and the coatings are porous, allowing blood -- and blood sugar -- to reach the nanoparticle cores.

 

"This technology effectively creates a 'closed-loop' system that mimics the activity of the pancreas in a healthy person, releasing insulin in response to glucose level changes," Gu says. "This has the potential to improve the health and quality of life of diabetes patients."

Gu's research team is currently in discussions to move the technology into clinical trials for use in humans.


Via Dr. Stefan Gruenwald
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The Organist | The Scientist Magazine®

The Organist | The Scientist Magazine® | Alternatives and refinements to animal research | Scoop.it
When molecular biology methods failed her, Sangeeta Bhatia turned to engineering and microfabrication to build a liver from scratch.
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Blog: Using maths to reduce animal experiments

Blog: Using maths to reduce animal experiments | Alternatives and refinements to animal research | Scoop.it
The Maths Study Group is helping biologists to think about their 3Rs problems in ways they never had before.
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Industry evidence sets animal welfare benchmark for short-term toxicity studies - Drug Discovery Today

Industry evidence sets animal welfare benchmark for short-term toxicity studies - Drug Discovery Today | Alternatives and refinements to animal research | Scoop.it
10% upper limit of bodyweight loss sufficient to determine maximum-tolerated dose
National Centre for the 3Rs - Pioneering Better Science's insight:

Acting as an honest broker in this way has proven successful to identify an objective methodology to minimise animal suffering in short-term toxicity studies. Defining the maximum-tolerated dose is crucially important for this in addition to making it easier to select an appropriate dose for future studies.

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