Alternatives and refinements to animal research
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Alternatives and refinements to animal research
News about the replacement and reduction of animals in scientific research, and improvements in welfare practice.
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'Body on a chip' used for drug tests

'Body on a chip' used for drug tests | Alternatives and refinements to animal research | Scoop.it
A technology which puts miniature human organs made with a 3D printer on a microchip is being used to test new drugs and vaccines.
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Basel Declaration Award goes to an italian researcher | SciencePlug

Basel Declaration Award goes to an italian researcher | SciencePlug | Alternatives and refinements to animal research | Scoop.it
Chiara, this year winner, will have the possibility to take part to a one-week course on animal research at the University of Zurich, where the 3Rs rules (Replacement, Reduction, Refinement) of laboratory animal science will be ...
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Cancer research implies future for personalized medicine, reduction in animal testing

Cancer research implies future for personalized medicine, reduction in animal testing | Alternatives and refinements to animal research | Scoop.it
On August 6th, JoVE, the Journal of Visualized Experiments, will publish two new methods for scientists to study and treat tumor growth.
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Blog: Driving the 3Rs into the centre of mainstream science

Blog: Driving the 3Rs into the centre of mainstream science | Alternatives and refinements to animal research | Scoop.it
Professor Ian Kimber on the growing appreciation for 3Rs to address important scientific questions
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Inbred and well bred? | NC3Rs blog

Inbred and well bred? | NC3Rs blog | Alternatives and refinements to animal research | Scoop.it

With commonly held beliefs of mice breeding now being challenged, is it time to rewrite the husbandry rule books? 

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Transparency in research using animals

Transparency in research using animals | Alternatives and refinements to animal research | Scoop.it
The past two days have seen scientists, animal welfare officers, funding agencies and journal editors gather together in London for the 3rd Basel Declaration Society Conference. The focus?
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Developing a powerful computer model of inflammation | NC3Rs blog

Developing a powerful computer model of inflammation | NC3Rs blog | Alternatives and refinements to animal research | Scoop.it
National Centre for the 3Rs - Pioneering Better Science's insight:

“Scientists from all fields need to be aware of the possible methodologies that can be used to investigate a certain research question. Many techniques are already available and will be developed further in the future, but only their application makes them powerful tools.” 

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NC3Rs announces two David Sainsbury Fellowships

NC3Rs announces two David Sainsbury Fellowships | Alternatives and refinements to animal research | Scoop.it
Early-career fellowships awarded to develop methods that reduce animal use across Parkinson’s disease and inflammation research
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Blog: Improve cross-talk, fewer mouse models and coconuts

Highlights from this week's joint symposium with the Society of Biology
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New test for skin sensitization without using animals

New test for skin sensitization without using animals | Alternatives and refinements to animal research | Scoop.it
In an advance in efforts to reduce the use of animals in testing new cosmetic and other product ingredients for skin allergies, scientists are describing a new, highly accurate non-animal test for these skin-sensitizers.
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Prize for reduction and refinement of animal experiments

Prize for reduction and refinement of animal experiments | Alternatives and refinements to animal research | Scoop.it
Associate professor Gøril Eide Flaten from the University of Tromsø was awarded Norepocas (Norwegian consensus platform for replacement, reduction and refinement of animal experiment) 3R prize for the development of the in vitro PVPA model for...
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£250k prize offered to encourage human toxicology breakthrough

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Lab-grown skin test spots problems with new chemicals | News | The Engineer

Lab-grown skin test spots problems with new chemicals | News | The Engineer | Alternatives and refinements to animal research | Scoop.it
UK researchers have developed a way to test new chemical products on lab-grown skin as an alternative to animal testing.
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Maximizing the Impact of Research: New Reporting Guidelines Collection from PLOS | Speaking of Medicine

Maximizing the Impact of Research: New Reporting Guidelines Collection from PLOS | Speaking of Medicine | Alternatives and refinements to animal research | Scoop.it
RT @DrKLidster: Blog explaining the new @PLOS collections on reporting guidelines http://t.co/S7eUa4dJDQ including @NC3Rs #ARRIVEguidelines
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Blog: The 3Rs – an integral part of scientific training

Dr Carl Westmoreland on his work associated with replacing animal use, and the key role of the NC3Rs
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Engineered mice act as hepatitis C model

Engineered mice act as hepatitis C model | Alternatives and refinements to animal research | Scoop.it
Rodents may eventually replace chimpanzees in vaccine research.
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Research focus: Genetically modified mice

Research focus: Genetically modified mice | Alternatives and refinements to animal research | Scoop.it
Factsheet highlighting NC3Rs role in developing innovative 3Rs approaches in GM research.
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JRC nominates the first members of the EU Network of Laboratories for the Validation of Alternative Methods (EU-NETVAL) — Institute for Health and Consumer Protection – (JRC-IHCP), European Commission

JRC nominates the first members of the EU Network of Laboratories for the Validation of Alternative Methods (EU-NETVAL) — Institute for Health and Consumer Protection – (JRC-IHCP), European Commission | Alternatives and refinements to animal research | Scoop.it
An important step to strengthen the EU's capacity to validate new methods that reduce, refine or replace animal testing
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Stem-cell livers grown in laboratory

Stem-cell livers grown in laboratory | Alternatives and refinements to animal research | Scoop.it
Tiny functioning human livers have been grown in the laboratory by scientists in Japan.
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New from old, the search for Parkinson’s disease treatments | NC3Rs blog

New from old, the search for Parkinson’s disease treatments | NC3Rs blog | Alternatives and refinements to animal research | Scoop.it
National Centre for the 3Rs - Pioneering Better Science's insight:

“…compared with traditional drug development we would have saved an average of five years and hundreds of animals. So this approach not only will save time, but also animals and money.” 

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Spontaneously beating human cardiac microtissue scoops 3Rs poster prize

Prize awarded for in vitro method that could replace dog cardiomyocytes in cardiotoxicity assays.
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Testing Asthma Drugs on a Microchip

Testing Asthma Drugs on a Microchip | Alternatives and refinements to animal research | Scoop.it
Forget lab rats. Some researchers are now testing medicines on a silicon chip that could provide a better read on how a drug will work.
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Bringing asthma research into sharp focus | NC3Rs blog

Bringing asthma research into sharp focus | NC3Rs blog | Alternatives and refinements to animal research | Scoop.it
National Centre for the 3Rs - Pioneering Better Science's insight:

Dan Richards talks to NC3Rs David Sainsbury Fellow, Dr Amanda Tatler, University of Nottingham, who is looking for new drug targets by applying an approach to measure lung function that has seen little use in asthma research, and uses more than 80 per cent fewer animals than conventional methods. If successful this could significantly reduce the use of animals across the whole asthma field.

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2D to 3D, not just a revolution on our TV screens | NC3Rs blog

2D to 3D, not just a revolution on our TV screens | NC3Rs blog | Alternatives and refinements to animal research | Scoop.it

Growing cells in flat, 2D layers for research has been the norm for around 40 years and is a method with many limitations. Culturing living human cells in 3D spheres has been recently found to be more physiologically relevant to humans. NC3Rs 3Rs Prize runner-up, Professor Shuichi Takayama, University of Michigan USA, describes how this novel method can be applied to metastatic cancer research, screening out drugs that do not work much earlier in the drug discovery process to reduce the number of animals needed overall.

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Lords Bill proposes animal research labelling for medicines | Chemistry World

Lords Bill proposes animal research labelling for medicines | Chemistry World | Alternatives and refinements to animal research | Scoop.it
Bill aims to underline the necessity of animal experiments, says Robert Winston
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