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Curated by Gust MEES
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Rescooped by Gust MEES from Cancer Immunotherapy Review
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New Cancer Vaccine Approach Directly Targets Dendritic Cells

New Cancer Vaccine Approach Directly Targets Dendritic Cells | 21st Century Innovative Technologies and Developments as also discoveries, curiosity ( insolite)... | Scoop.it

"Celldex Therapeutics announced today that final data from its Phase 1 study of CDX-1401 in solid tumors, including long-term patient follow-up, have been published inScience Translational Medicine.


The data demonstrate robust antibody and T cell responses and evidence of clinical benefit in patients with very advanced cancers and suggest that CDX-1401 may predispose patients to better outcomes on subsequent therapy with checkpoint inhibitors. CDX-1401 is an off-the-shelf vaccine consisting of a fully human monoclonal antibody with specificity for the dendritic cell receptor DEC-205 linked to the NY-ESO-1 tumor antigen. The vaccine is designed to activate the patient's immune system against cancers that express the tumor marker NY-ESO-1.


While the function of NY-ESO-1 continues to be explored, references in the literature suggest that its expression might reflect the acquisition of properties that cancers find useful, such as immortality, self-renewal, migratory ability and the capacity to invade."

 

Editor's note: Cancer vaccines like CDX-1401 are a type of immunotherapy, meaning that they boost a patient's own immune system to fight cancer. CDX-1401 is able to attack tumor cells because the tumor cells have a molecule called NY-ESO-1 that CDX-1401 recognizes. We recently published a story about another treatment that is meant for patients whose tumors have NY-ESO-1. 


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Via Cancer Commons, Krishan Maggon
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Cancer Commons's curator insight, April 16, 2014 10:21 PM

Medical Xpress  |  Apr 16, 2014

Cancer Commons's curator insight, April 16, 2014 10:22 PM

Medical Xpress  |  Apr 16, 2014

Rescooped by Gust MEES from Cancer Immunotherapy Review
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Immunotherapy data heralds new era of lung cancer treatment

Immunotherapy data heralds new era of lung cancer treatment | 21st Century Innovative Technologies and Developments as also discoveries, curiosity ( insolite)... | Scoop.it
Immunotherapy data heralds new era of lung cancer treatment Science Codex For decades, scientists and doctors thought immunotherapy –treatments that harness the immune system to fight a disease-- was of marginal benefit in lung cancer, says...

Via Krishan Maggon
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